HitPredict

Interactor 1: INSRR (P14616)
Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
Gene: INSRR

Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	33961781, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1297 Hs			1 378
+	Hs
		435654 IGF1R_HUMAN (9-1265): 0: 1222: 55.39		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		411399 INSR_HUMAN (27-1288): 0: 1183: 52.18		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Dm
		448241 INSR_DROME (2-1254): 0: 928: 34.30		CDC37_DROME (1-351): 1.28e-126: 371: 52.54
+	Hs
		665401 EPHA3_HUMAN (453-1255): 0: 617: 21.02		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		872655 EPHA4_HUMAN (455-1279): 0: 609: 20.55		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		665610 EPHB2_HUMAN (455-1264): 0: 605: 19.86		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1072507 EPHA7_HUMAN (454-1280): 0: 598: 20.58		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		872447 EPHA5_HUMAN (454-1279): 0: 591: 19.78		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		872537 EPHB4_HUMAN (455-1269): 0: 581: 21.32		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1083031 EPHA6_HUMAN (454-1254): 0: 578: 19.82		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		665480 EPHA8_HUMAN (454-1268): 2.42e-179: 558: 20.16		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		665253 EPHA2_HUMAN (455-1282): 9.77e-179: 556: 21.20		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		171305 EPHB6_HUMAN (645-1291): 7.18e-161: 510: 23.91		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		600580 EPHA1_HUMAN (657-1279): 2.19e-159: 505: 23.51		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		666606 LTK_HUMAN (969-1291): 4.92e-73: 264: 42.17		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1083044 ALK_HUMAN (946-1247): 1.07e-70: 263: 43.46		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1082785 NTRK2_HUMAN (957-1253): 1.12e-67: 247: 42.43		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		169179 MUSK_HUMAN (973-1242): 8.31e-67: 245: 42.61		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		384911 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1081495 NTRK3_HUMAN (957-1242): 2.05e-62: 231: 40.84		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00