HitPredict

Interactor 1: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Interactor 2: MK15 (Q8TD08)
Mitogen-activated protein kinase 15 (MAP kinase 15) (MAPK 15) (EC 2.7.11.24) (Extracellular signal-regulated kinase 7) (ERK-7) (Extracellular signal-regulated kinase 8) (ERK-8)
Gene: MAPK15

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005576 - extracellular region GO:0005634 - nucleus GO:0006974 - DNA damage response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 803 Hs			1 544
+	Hs
		438381 HS90B_HUMAN (75-783): 0: 997: 46.54		MK15_HUMAN (1-544): 0: 545: 100.00
+	Hs
		432091 HS90A_HUMAN (60-783): 0: 990: 45.34		MK15_HUMAN (1-544): 0: 545: 100.00
+	Hs
		538107 ENPL_HUMAN (1-803): 0: 1073: 100.00		CDK2_HUMAN (10-315): 6.34e-141: 410: 38.31
+	Hs
		437908 HS90B_HUMAN (75-783): 0: 997: 46.54		CDK2_HUMAN (10-315): 6.34e-141: 410: 38.31
+	Hs
		431549 HS90A_HUMAN (60-783): 0: 990: 45.34		CDK2_HUMAN (10-315): 6.34e-141: 410: 38.31
+	Hs
		438208 HS90B_HUMAN (75-783): 0: 997: 46.54		MK14_HUMAN (8-355): 1.49e-135: 399: 38.92
+	Hs
		438075 HS90B_HUMAN (75-783): 0: 997: 46.54		CDK3_HUMAN (10-316): 8.82e-136: 397: 38.19
+	Hs
		431896 HS90A_HUMAN (60-783): 0: 990: 45.34		MK14_HUMAN (8-355): 1.49e-135: 399: 38.92
+	Hs
		431741 HS90A_HUMAN (60-783): 0: 990: 45.34		CDK3_HUMAN (10-316): 8.82e-136: 397: 38.19
+	Mm
		432419 HS90A_MOUSE (60-783): 0: 985: 45.28		MK01_MOUSE (1-352): 3.16e-136: 400: 39.44
+	Dm
		772971 Q9VAY2_DROME (16-751): 0: 919: 62.28		ERKA_DROME (12-355): 2.42e-133: 394: 40.63
+	Rn
		600453 ENPL_RAT (1-803): 0: 1055: 95.03		MK03_RAT (12-313): 1.32e-77: 251: 45.25
+	Sc
		365698 HSP82_YEAST (72-783): 0: 867: 47.17		KSS1_YEAST (1-346): 4.36e-138: 405: 41.14
+	Rn
		600340 HS90B_RAT (75-783): 0: 998: 46.26		MK03_RAT (12-313): 1.32e-77: 251: 45.25
+	Hs
		437913 HS90B_HUMAN (75-783): 0: 997: 46.54		MK03_HUMAN (12-313): 8.66e-78: 251: 45.25
+	Hs
		431555 HS90A_HUMAN (60-783): 0: 990: 45.34		MK03_HUMAN (12-313): 8.66e-78: 251: 45.25
+	Rn
		600383 HS90A_RAT (60-783): 0: 988: 45.28		MK03_RAT (12-313): 1.32e-77: 251: 45.25
+	Mm
		432433 HS90A_MOUSE (60-783): 0: 985: 45.28		MK03_MOUSE (12-313): 1.32e-77: 251: 45.25
+	At
		850798 HS903_ARATH (71-783): 0: 955: 49.65		MPK10_ARATH (17-313): 7.11e-80: 257: 45.33
+	Sc
		543134 HSC82_YEAST (72-783): 0: 869: 47.57		FUS3_YEAST (13-313): 8.9e-81: 258: 45.81