Interactor 1: IL2RB (P14784)
Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
Gene: IL2RB
Interactor 2: IL2 (P60568)
Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)
Gene: IL2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.92 | 1.00 | 0.962 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 22446627, 8006584, 1940342, 3095922, 3098894, 15178252, 8568232 |
| Identification Methods | surface plasmon resonance, biophysical, isothermal titration calorimetry, competition binding, anti tag coimmunoprecipitation, protein cross-linking with a bifunctional reagent |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | IL2~IL2RB_N1 |
| Common GO terms | GO:0038110 - interleukin-2-mediated signaling pathway GO:0043066 - negative regulation of apoptotic process |
| Homologous interactions | 2 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
