HitPredict

Interactor 1: CCNA (P14785)
G2/mitotic-specific cyclin-A
Gene: CycA

Interactor 2: CDK1 (P23572)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.951

Property	Details
Experiments	17431409, 24214341, 8156587, 8980229, 11027291, 22036573, unassigned4
Identification Methods	affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation, experimental interaction detection
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0045169 - fusome GO:0055059 - asymmetric neuroblast division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 491 Dm			1 297
+	Dm
		540473 CCNA_DROME (1-491): 2.3e-161: 468: 100.00		CDK2_DROME (1-291): 4.39e-134: 383: 56.70
+	Hs
		625350 CCNA1_HUMAN (45-454): 1.17e-123: 370: 34.63		CDK2_HUMAN (1-293): 7.76e-161: 450: 62.80
+	Hs
		538471 CCNB1_HUMAN (49-453): 1.92e-118: 356: 23.83		CDK2_HUMAN (1-293): 7.76e-161: 450: 62.80
+	Mm
		956329 CCNA1_MOUSE (45-455): 2.19e-120: 361: 34.14		CDK2_MOUSE (1-293): 8.94e-152: 430: 53.67
+	Hs
		414855 CCNA1_HUMAN (45-454): 1.17e-123: 370: 34.63		CDK1_HUMAN (1-292): 1.95e-146: 414: 72.95
+	Hs
		538521 CCNB1_HUMAN (49-453): 1.92e-118: 356: 23.83		CDK3_HUMAN (1-289): 1.07e-151: 428: 65.40
+	Mm
		851183 CCNA2_MOUSE (34-455): 5.02e-117: 352: 36.60		CDK2_MOUSE (1-293): 8.94e-152: 430: 53.67
+	Hs
		414711 CCNB1_HUMAN (49-453): 1.92e-118: 356: 23.83		CDK1_HUMAN (1-292): 1.95e-146: 414: 72.95
+	Mm
		509476 CCNA2_MOUSE (34-455): 5.02e-117: 352: 36.60		CDK1_MOUSE (1-292): 4.41e-145: 411: 72.60
+	At
		621704 CCB23_ARATH (38-454): 9.14e-118: 354: 24.71		CDKA1_ARATH (1-290): 3.16e-143: 406: 63.23
+	Mm
		509465 CCNB1_MOUSE (49-452): 2.44e-115: 348: 23.11		CDK1_MOUSE (1-292): 4.41e-145: 411: 72.60
+	At
		621662 CCA21_ARATH (19-460): 4.93e-115: 347: 28.00		CDKA1_ARATH (1-290): 3.16e-143: 406: 63.23
+	Hs
		538522 CCNB1_HUMAN (49-453): 1.92e-118: 356: 23.83		CDK5_HUMAN (1-293): 1.86e-138: 394: 55.78
+	At
		1103371 CCB23_ARATH (38-454): 9.14e-118: 354: 24.71		CKB12_ARATH (1-294): 1.56e-132: 380: 50.80
+	At
		1321297 CCB23_ARATH (38-454): 9.14e-118: 354: 24.71		CDKD1_ARATH (2-295): 3.92e-131: 379: 43.20
+	At
		1103352 CCA21_ARATH (19-460): 4.93e-115: 347: 28.00		CKB12_ARATH (1-294): 1.56e-132: 380: 50.80
+	At
		639365 CCB23_ARATH (38-454): 9.14e-118: 354: 24.71		CKB11_ARATH (1-294): 3.46e-129: 371: 50.49
+	At
		1106945 CCA21_ARATH (19-460): 4.93e-115: 347: 28.00		CKB21_ARATH (1-295): 1.75e-131: 377: 48.19
+	At
		639373 CCB24_ARATH (36-454): 3.32e-116: 350: 26.16		CKB11_ARATH (1-294): 3.46e-129: 371: 50.49
+	At
		639343 CCA21_ARATH (19-460): 4.93e-115: 347: 28.00		CKB11_ARATH (1-294): 3.46e-129: 371: 50.49