HitPredict

Interactor 1: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Interactor 2: RHOQ (P17081)
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)
Gene: RHOQ

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Arm~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 205
+	Hs
		542444 PLAK_HUMAN (1-745): 0: 551: 100.00		RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59
+	Hs
		717346 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RHOJ_HUMAN (9-204): 1.17e-108: 311: 79.59
+	Hs
		542276 PLAK_HUMAN (1-745): 0: 551: 100.00		RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97
+	Hs
		542271 PLAK_HUMAN (1-745): 0: 551: 100.00		RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98
+	Hs
		542255 PLAK_HUMAN (1-745): 0: 551: 100.00		CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57
+	Hs
		542258 PLAK_HUMAN (1-745): 0: 551: 100.00		RHOA_HUMAN (1-201): 1.3e-76: 230: 49.75
+	Hs
		542164 PLAK_HUMAN (1-745): 0: 551: 100.00		RAC2_HUMAN (10-196): 1.67e-76: 229: 62.03
+	Hs
		542254 PLAK_HUMAN (1-745): 0: 551: 100.00		RAC3_HUMAN (10-183): 9.1e-76: 227: 66.67
+	Hs
		542268 PLAK_HUMAN (1-745): 0: 551: 100.00		RHOB_HUMAN (1-204): 1.77e-75: 227: 49.51
+	Hs
		436141 PLAK_HUMAN (1-745): 0: 551: 100.00		RHOC_HUMAN (1-192): 1.16e-74: 225: 50.52
+	Hs
		564428 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RHOQ_HUMAN (1-205): 2.78e-83: 247: 100.00
+	Hs
		716991 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RHOG_HUMAN (9-199): 2.46e-81: 241: 54.97
+	Hs
		716971 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RAC1_HUMAN (10-195): 4.15e-80: 238: 63.98
+	Mm
		925786 CTNB1_MOUSE (1-731): 2.79e-173: 518: 67.38		RAC1_MOUSE (10-195): 4.15e-80: 238: 63.98
+	Hs
		716931 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CDC42_HUMAN (9-193): 1.09e-78: 235: 67.57
+	Hs
		716935 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RHOA_HUMAN (1-201): 1.3e-76: 230: 49.75
+	Hs
		545229 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RAC2_HUMAN (10-196): 1.67e-76: 229: 62.03
+	Hs
		716929 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RAC3_HUMAN (10-183): 9.1e-76: 227: 66.67
+	Hs
		716955 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		RHOB_HUMAN (1-204): 1.77e-75: 227: 49.51
+	Mm
		677654 CTND1_MOUSE (207-730): 3.06e-94: 315: 16.42		RHOA_MOUSE (1-204): 6.67e-77: 230: 49.02