Protein: TOP1
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) (Maintenance of killer protein 1)

Gene: TOP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 83
UniProt ID: P04786

Gene Ontology (top 5):
GO:0000019 - regulation of mitotic recombination
GO:0000183 - rDNA heterochromatin formation
GO:0003677 - DNA binding
GO:0003917 - DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

415212

SPT16
FACT complex subunit SPT16

3

1

High-throughput

0.662

High

415205

NSR1
Nuclear localization sequence-binding protein

3

1

Small-scale

0.646

High

415197

REB1
DNA-binding protein REB1

2

1

High-throughput

0.621

High

415213

RPD3
Histone deacetylase RPD3

2

2

High-throughput

0.621

High

415246

POB3
FACT complex subunit POB3

2

3

High-throughput

0.601

High

415249

TRI1
Protein TRI1

2

0

High-throughput

0.594

High

415236

TOF1
Topoisomerase 1-associated factor 1

2

0

Small-scale

0.593

High

381343

H2B2
Histone H2B.2

2

3

High-throughput

0.588

High

415209

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

0

High-throughput

0.585

High

415208

MCM4
DNA replication licensing factor MCM4

2

6

Small-scale

0.584

High

415262

CMR1
DNA damage-binding protein CMR1

2

4

High-throughput

0.584

High

415237

APJ1
J domain-containing protein APJ1

2

1

High-throughput

0.571

High

415230

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.559

High

415241

SLD5
DNA replication complex GINS protein SLD5

2

0

Small-scale

0.559

High

415192

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.536

High

415193

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.536

High

415194

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.536

High

415202

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.536

High

415226

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.536

High

415240

ABF2
ARS-binding factor 2, mitochondrial

1

6

High-throughput

0.536

High

415239

TOF2
Topoisomerase 1-associated factor 2

1

0

Small-scale

0.529

High

415218

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

7

High-throughput

0.515

High

415219

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.515

High

403286

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

1

High-throughput

0.500

High

149180

FOB1
DNA replication fork-blocking protein FOB1

1

0

Small-scale

0.493

High

415220

NCB5R
NADH-cytochrome b5 reductase 1

1

0

High-throughput

0.493

High

415248

SML1
Ribonucleotide reductase inhibitor protein SML1

1

0

High-throughput

0.493

High

415254

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.481

High

415217

NNK1
Nitrogen network kinase 1

1

0

High-throughput

0.480

High

415222

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.480

High

381768

H4
Histone H4

1

1

High-throughput

0.479

High

415186

H2A1
Histone H2A.1

1

4

Small-scale

0.479

High

415187

H2A2
Histone H2A.2

1

4

Small-scale

0.479

High

415189

SIR2
NAD-dependent histone deacetylase SIR2

1

1

Small-scale

0.479

High

415195

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

415199

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

415204

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

415207

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

415227

ATAD2
ATPase histone chaperone YTA7

1

2

High-throughput

0.479

High

415228

MPH1
ATP-dependent DNA helicase MPH1

1

6

High-throughput

0.479

High

415238

H3
Histone H3

1

3

Small-scale

0.479

High

415244

SIZ1
E3 SUMO-protein ligase SIZ1

1

3

High-throughput

0.479

High

415259

SMT3
Ubiquitin-like protein SMT3

1

1

High-throughput

0.479

High

415261

DBP10
ATP-dependent RNA helicase DBP10

1

5

High-throughput

0.479

High

415257

TIR4
Cell wall protein TIR4

1

1

High-throughput

0.470

High

415198

RE107
Recombination protein 107

1

0

High-throughput

0.460

High

415211

MEI5
Meiosis protein 5

1

0

High-throughput

0.460

High

415232

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

Small-scale

0.460

High

415203

MRC1
Mediator of replication checkpoint protein 1

1

0

Small-scale

0.458

High

415206

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

415215

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

415243

LRS4
Monopolin complex subunit LRS4

1

0

Small-scale

0.458

High

415247

CSM3
Chromosome segregation in meiosis protein 3

1

0

Small-scale

0.458

High

415250

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

415252

RLP24
Ribosome biogenesis protein RLP24

1

0

Small-scale

0.458

High

415253

SGO1
Shugoshin

1

0

High-throughput

0.458

High

415255

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

415256

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

415201

SIS1
Protein SIS1

1

1

High-throughput

0.445

High

415214

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

415223

CAJ1
Protein CAJ1

1

2

High-throughput

0.445

High

415233

DPH4
Diphthamide biosynthesis protein 4

1

1

High-throughput

0.445

High

415210

SMY1
Kinesin-related protein SMY1

1

2

High-throughput

0.439

High

391952

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.426

High

415200

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

415221

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

415191

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.407

High

415225

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.407

High

415229

DJP1
DnaJ-like protein 1

1

2

High-throughput

0.407

High

415196

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.279

Low

415231

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.279

Low

415242

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.279

Low

415224

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.269

Low

415235

MPS2
Monopolar spindle protein 2

1

0

High-throughput

0.251

Low

415258

NYV1
Vacuolar v-SNARE NYV1

1

0

High-throughput

0.251

Low

415263

ATG11
Autophagy-related protein 11

1

0

High-throughput

0.251

Low

415188

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.249

Low

415190

CBP8
Cytochrome B pre-mRNA-processing protein 1

1

0

High-throughput

0.249

Low

415234

TPN1
Vitamin B6 transporter TPN1

1

0

High-throughput

0.249

Low

415216

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

415245

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.232

Low

415251

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low

415260

JID1
J domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025