HitPredict

Interactor 1: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Interactor 2: CADH8 (P55286)
Cadherin-8
Gene: CDH8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Arm~CADH_Y-type_LIR
Common GO terms	GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0016342 - catenin complex GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 799
+	Hs
		716915 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CADH8_HUMAN (1-799): 0: 851: 100.00
+	Hs
		521702 PLAK_HUMAN (1-745): 0: 551: 100.00		CADH1_HUMAN (33-796): 0: 646: 33.63
+	Hs
		542286 PLAK_HUMAN (1-745): 0: 551: 100.00		DSC2_HUMAN (36-788): 0: 620: 25.99
+	Hs
		521758 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CADH1_HUMAN (33-796): 0: 646: 33.63
+	Hs
		542323 PLAK_HUMAN (1-745): 0: 551: 100.00		DSC3_HUMAN (37-788): 0: 614: 25.71
+	Hs
		542294 PLAK_HUMAN (1-745): 0: 551: 100.00		DSC1_HUMAN (34-788): 0: 594: 27.83
+	Hs
		542490 PLAK_HUMAN (1-745): 0: 551: 100.00		CAD10_HUMAN (3-486): 1.32e-95: 317: 22.00
+	Hs
		716917 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CAD12_HUMAN (3-486): 2.7e-96: 319: 23.98
+	Hs
		716916 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CAD11_HUMAN (2-490): 1.24e-95: 317: 23.14
+	Hs
		716914 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CADH6_HUMAN (3-486): 5.37e-95: 315: 22.31
+	Hs
		542178 PLAK_HUMAN (1-745): 0: 551: 100.00		CADH2_HUMAN (4-486): 4.15e-64: 232: 21.92
+	Hs
		542185 PLAK_HUMAN (1-745): 0: 551: 100.00		CADH3_HUMAN (20-447): 6.71e-58: 213: 22.15
+	Gg
		193807 O42486_CHICK (1-731): 4.63e-176: 525: 67.51		CADH2_CHICK (4-490): 2.76e-65: 236: 20.83
+	Hs
		580207 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CADH2_HUMAN (4-486): 4.15e-64: 232: 21.92
+	Hs
		606301 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CADH3_HUMAN (20-447): 6.71e-58: 213: 22.15
+	Cl
		80821 CTNB1_CANLF (1-731): 1.59e-173: 519: 67.38		CADH1_CANLF (1-359): 1.04e-35: 147: 19.12
+	Mm
		877530 PLAK_MOUSE (1-745): 0: 553: 98.39		CADH5_MOUSE (2-157): 2.32e-10: 66.1: 12.94
+	Hs
		542209 PLAK_HUMAN (1-745): 0: 551: 100.00		CADH5_HUMAN (2-157): 2.77e-10: 66.1: 11.83
+	Hs
		702745 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CADH5_HUMAN (2-157): 2.77e-10: 66.1: 11.83
+	Hs
		716913 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		CADH4_HUMAN (1-163): 7.05e-10: 64.9: 13.79