Protein: APAF
Apoptotic protease-activating factor 1 (APAF-1)

Gene: APAF, APAF1
Organism: Homo sapiens
Interactions: 84
UniProt ID: O14727

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0001666 - response to hypoxia
GO:0001822 - kidney development
GO:0001843 - neural tube closure
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

161704

CASP9
Caspase-9

21

5

Small-scale

0.988

High

161731

WDFY3
WD repeat and FYVE domain-containing protein 3

2

14

High-throughput

0.811

High

161712

CYC
Cytochrome c

3

0

Small-scale

0.803

High

161711

XIAP
E3 ubiquitin-protein ligase XIAP

2

7

Small-scale

0.754

High

161714

B2CL1
Bcl-2-like protein 1

2

1

Small-scale

0.754

High

161740

TCPQM
T-complex protein 1 subunit theta-like 2

1

20

High-throughput

0.691

High

161749

NLRP1
NACHT, LRR and PYD domains-containing protein 1

1

1

Small-scale

0.691

High

161755

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

4

High-throughput

0.691

High

161760

TRI35
E3 ubiquitin-protein ligase TRIM35

1

3

High-throughput

0.691

High

161761

PSG11
Pregnancy-specific beta-1-glycoprotein 11

1

2

High-throughput

0.691

High

161696

HSP74
Heat shock 70 kDa protein 4

3

11

Small-scale

0.674

High

161722

H31T
Histone H3.1t

1

10

High-throughput

0.665

High

161745

NAA11
N-alpha-acetyltransferase 11

1

0

High-throughput

0.656

High

161744

OMD
Osteomodulin

2

1

High-throughput

0.628

High

161701

ARL4D
ADP-ribosylation factor-like protein 4D

1

6

High-throughput

0.618

High

161750

DNAI2
Dynein axonemal intermediate chain 2

1

18

High-throughput

0.618

High

161686

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

161700

CASP4
Caspase-4

1

5

Small-scale

0.618

High

161751

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.602

High

161756

B2L10
Bcl-2-like protein 10

1

0

Small-scale

0.586

High

161741

CD006
Uncharacterized protein encoded by LINC01587

2

0

High-throughput

0.585

High

161737

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.578

High

161685

PRKY
Putative serine/threonine-protein kinase PRKY

1

3

High-throughput

0.575

High

161728

DEFI8
Differentially expressed in FDCP 8 homolog

2

5

High-throughput

0.574

High

161692

HS90A
Heat shock protein HSP 90-alpha

2

9

Small-scale

0.563

High

161705

NU107
Nuclear pore complex protein Nup107

1

1

Small-scale

0.561

High

161730

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.553

High

161739

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

Small-scale

0.549

High

161707

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

7

High-throughput

0.546

High

161698

CASP3
Caspase-3

2

5

Small-scale

0.538

High

74392

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

14

High-throughput

0.536

High

158377

RFXK
DNA-binding protein RFXANK

1

8

High-throughput

0.536

High

161682

PI51B
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta

1

3

High-throughput

0.536

High

161687

EVI5
Ecotropic viral integration site 5 protein homolog

1

1

High-throughput

0.536

High

161699

LEG7
Galectin-7

1

6

High-throughput

0.536

High

161713

PPARD
Peroxisome proliferator-activated receptor delta

1

20

High-throughput

0.536

High

161721

IKBB
NF-kappa-B inhibitor beta

1

6

High-throughput

0.536

High

161725

EFMT2
EEF1A lysine methyltransferase 2

1

1

High-throughput

0.536

High

161727

LYPD4
Ly6/PLAUR domain-containing protein 4

1

3

High-throughput

0.536

High

161738

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

161743

NPAS1
Neuronal PAS domain-containing protein 1

1

9

High-throughput

0.536

High

161746

AASD1
Alanyl-tRNA editing protein Aarsd1

1

1

High-throughput

0.536

High

161747

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.536

High

161758

HSPB8
Heat shock protein beta-8

1

4

High-throughput

0.536

High

161689

RL1D1
Ribosomal L1 domain-containing protein 1

1

11

High-throughput

0.515

High

161683

RA51B
DNA repair protein RAD51 homolog 2

1

0

High-throughput

0.513

High

161690

LGI1
Leucine-rich glioma-inactivated protein 1

1

0

High-throughput

0.513

High

161702

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.513

High

161723

RPEL1
Ribulose-phosphate 3-epimerase-like protein 1

1

0

High-throughput

0.513

High

161726

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.513

High

161736

NT5C
5'(3')-deoxyribonucleotidase, cytosolic type

1

0

High-throughput

0.513

High

161748

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

161754

BAFL
Barrier-to-autointegration factor-like protein

1

0

High-throughput

0.513

High

161757

AVEN
Cell death regulator Aven

1

0

Small-scale

0.493

High

161688

CIB2
Calcium and integrin-binding family member 2

1

3

High-throughput

0.489

High

161695

CRBB3
Beta-crystallin B3

1

2

High-throughput

0.489

High

161703

CRBA4
Beta-crystallin A4

1

2

High-throughput

0.489

High

161706

YPEL3
Protein yippee-like 3

1

1

High-throughput

0.489

High

161724

UROL1
Uromodulin-like 1

1

2

High-throughput

0.489

High

161732

CLASR
CLK4-associating serine/arginine rich protein

1

4

High-throughput

0.489

High

161753

KLK15
Kallikrein-15

1

3

High-throughput

0.489

High

161759

AT7L1
Ataxin-7-like protein 1

1

8

High-throughput

0.489

High

130887

HIP1
Huntingtin-interacting protein 1

1

8

Small-scale

0.479

High

133705

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

5

High-throughput

0.479

High

161691

P53
Cellular tumor antigen p53

1

9

High-throughput

0.479

High

161694

ENPL
Endoplasmin

1

9

Small-scale

0.479

High

161697

SYUA
Alpha-synuclein

1

3

High-throughput

0.479

High

161708

1433E
14-3-3 protein epsilon

1

3

Small-scale

0.479

High

161709

RHOG
Rho-related GTP-binding protein RhoG

1

11

High-throughput

0.479

High

161710

RL19
Large ribosomal subunit protein eL19

1

3

High-throughput

0.479

High

161715

TIF1B
Transcription intermediary factor 1-beta

1

15

High-throughput

0.479

High

161716

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

161717

CUL3
Cullin-3

1

20

High-throughput

0.479

High

161718

CUL4B
Cullin-4B

1

20

Small-scale

0.479

High

161719

CASP8
Caspase-8

1

5

Small-scale

0.479

High

161720

EEA1
Early endosome antigen 1

1

16

High-throughput

0.479

High

161742

DNJC7
DnaJ homolog subfamily C member 7

1

15

High-throughput

0.479

High

161752

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

161684

TRIA1
TP53-regulated inhibitor of apoptosis 1

1

0

Small-scale

0.458

High

161735

GMCL2
Germ cell-less protein-like 2

1

6

High-throughput

0.445

High

161693

TOP1
DNA topoisomerase 1

1

1

Small-scale

0.408

High

161729

PKHG7
Pleckstrin homology domain-containing family G member 7

1

11

High-throughput

0.407

High

161734

GG6L2
Golgin subfamily A member 6-like protein 2

1

19

High-throughput

0.407

High

161733

ENDOV
Endonuclease V

3

0

High-throughput

0.347

High


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Last updated: 11Aug2025