Protein: XRCC3
DNA repair protein XRCC3 (X-ray repair cross-complementing protein 3)

Gene: XRCC3
Organism: Homo sapiens
Interactions: 173
UniProt ID: O43542

Gene Ontology (top 5):
GO:0000400 - four-way junction DNA binding
GO:0000722 - telomere maintenance via recombination
GO:0000724 - double-strand break repair via homologous recombination
GO:0000781 - chromosome, telomeric region
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

206258

RA51C
DNA repair protein RAD51 homolog 3

18

17

Small-scale

0.990

High

207031

BRCA2
Breast cancer type 2 susceptibility protein

5

10

Small-scale

0.912

High

207041

RAD51
DNA repair protein RAD51 homolog 1

4

18

Small-scale

0.893

High

207116

TOM22
Mitochondrial import receptor subunit TOM22 homolog

3

1

High-throughput

0.675

High

174328

FANCG
Fanconi anemia group G protein

3

0

Small-scale

0.633

High

207008

LAMP2
Lysosome-associated membrane glycoprotein 2

2

1

High-throughput

0.628

High

207127

LAMP3
Lysosome-associated membrane glycoprotein 3

2

1

High-throughput

0.628

High

207080

GLMP
Glycosylated lysosomal membrane protein

2

0

High-throughput

0.602

High

207062

SWAP1
ATPase SWSAP1

1

4

Small-scale

0.578

High

207120

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

3

High-throughput

0.574

High

207068

PALB2
Partner and localizer of BRCA2

1

3

Small-scale

0.568

High

207022

SPB5
Serpin B5

1

1

High-throughput

0.541

High

207049

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

2

High-throughput

0.541

High

207061

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

6

High-throughput

0.541

High

207081

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.541

High

207091

LRAT2
Protein LRATD2

1

1

High-throughput

0.541

High

207121

HOP2
Homologous-pairing protein 2 homolog

1

2

High-throughput

0.541

High

206983

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

2

High-throughput

0.536

High

206986

IF2P
Eukaryotic translation initiation factor 5B

1

3

High-throughput

0.536

High

206987

DNJA2
DnaJ homolog subfamily A member 2

1

4

High-throughput

0.536

High

206991

SF3B1
Splicing factor 3B subunit 1

1

1

High-throughput

0.536

High

206994

DNJC8
DnaJ homolog subfamily C member 8

1

1

High-throughput

0.536

High

206996

UBR5
E3 ubiquitin-protein ligase UBR5

1

1

High-throughput

0.536

High

206999

S100B
Protein S100-B

1

2

High-throughput

0.536

High

207000

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.536

High

207002

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.536

High

207003

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.536

High

207005

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.536

High

207006

PYC
Pyruvate carboxylase, mitochondrial

1

3

High-throughput

0.536

High

207007

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.536

High

207009

ENPL
Endoplasmin

1

4

High-throughput

0.536

High

207010

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

High-throughput

0.536

High

207011

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.536

High

207013

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

1

High-throughput

0.536

High

207015

ATPA
ATP synthase subunit alpha, mitochondrial

1

4

High-throughput

0.536

High

207017

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

1

4

High-throughput

0.536

High

207018

DNJA1
DnaJ homolog subfamily A member 1

1

4

High-throughput

0.536

High

207023

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.536

High

207026

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.536

High

207028

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.536

High

207030

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.536

High

207033

RBM5
RNA-binding protein 5

1

2

High-throughput

0.536

High

207034

COPA
Coatomer subunit alpha

1

1

High-throughput

0.536

High

207035

PMS2
Mismatch repair endonuclease PMS2

1

3

High-throughput

0.536

High

207040

TAP1
Antigen peptide transporter 1

1

1

High-throughput

0.536

High

207042

CKAP4
Cytoskeleton-associated protein 4

1

2

High-throughput

0.536

High

207046

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

2

High-throughput

0.536

High

207048

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

2

High-throughput

0.536

High

207050

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

2

High-throughput

0.536

High

207060

UBR4
E3 ubiquitin-protein ligase UBR4

1

1

High-throughput

0.536

High

207064

HDGR2
Hepatoma-derived growth factor-related protein 2

1

2

High-throughput

0.536

High

207069

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

1

High-throughput

0.536

High

207070

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

1

High-throughput

0.536

High

207073

AGGF1
Angiogenic factor with G patch and FHA domains 1

1

2

High-throughput

0.536

High

207082

GCN1
Stalled ribosome sensor GCN1

1

2

High-throughput

0.536

High

207089

HOOK2
Protein Hook homolog 2

1

5

High-throughput

0.536

High

207092

IPO9
Importin-9

1

4

High-throughput

0.536

High

207097

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

1

2

High-throughput

0.536

High

207099

METH
Methionine synthase

1

1

High-throughput

0.536

High

207103

SFXN3
Sideroflexin-3

1

1

High-throughput

0.536

High

207104

TB182
182 kDa tankyrase-1-binding protein

1

2

High-throughput

0.536

High

207107

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

1

High-throughput

0.536

High

207108

UN45A
Protein unc-45 homolog A

1

1

High-throughput

0.536

High

207113

SFXN1
Sideroflexin-1

1

1

High-throughput

0.536

High

207123

EI2BD
Translation initiation factor eIF2B subunit delta

1

2

High-throughput

0.536

High

207124

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

3

High-throughput

0.536

High

207132

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

2

High-throughput

0.536

High

207136

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

1

High-throughput

0.536

High

207056

ZSWM7
Zinc finger SWIM domain-containing protein 7

1

1

Small-scale

0.527

High

206997

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.518

High

207054

ZNHI3
Zinc finger HIT domain-containing protein 3

1

0

High-throughput

0.518

High

207059

GREB1
Protein GREB1

1

0

High-throughput

0.518

High

207111

BCAS3
BCAS3 microtubule associated cell migration factor

1

0

High-throughput

0.518

High

118123

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.513

High

124681

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

High-throughput

0.513

High

149492

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

159444

QCR8
Cytochrome b-c1 complex subunit 8

1

0

High-throughput

0.513

High

199241

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.513

High

206984

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

High-throughput

0.513

High

206988

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

High-throughput

0.513

High

206989

MED24
Mediator of RNA polymerase II transcription subunit 24

1

0

High-throughput

0.513

High

206992

ERAL1
GTPase Era, mitochondrial

1

0

High-throughput

0.513

High

206995

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.513

High

207001

DPOLB
DNA polymerase beta

1

0

High-throughput

0.513

High

207014

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

High-throughput

0.513

High

207019

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.513

High

207024

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.513

High

207025

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.513

High

207029

CDK9
Cyclin-dependent kinase 9

1

0

High-throughput

0.513

High

207032

CLCN7
H(+)/Cl(-) exchange transporter 7

1

0

High-throughput

0.513

High

207036

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

0

High-throughput

0.513

High

207045

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.513

High

207053

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.513

High

207057

INF2
Inverted formin-2

1

0

High-throughput

0.513

High

207065

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.513

High

207072

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.513

High

207076

EXOC6
Exocyst complex component 6

1

0

High-throughput

0.513

High

207077

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

0

High-throughput

0.513

High

207078

CTF18
Chromosome transmission fidelity protein 18 homolog

1

0

High-throughput

0.513

High

207079

PCNP
PEST proteolytic signal-containing nuclear protein

1

0

High-throughput

0.513

High

207083

TNPO1
Transportin-1

1

0

High-throughput

0.513

High

207086

CC124
Coiled-coil domain-containing protein 124

1

0

High-throughput

0.513

High

207090

SPF45
Splicing factor 45

1

0

High-throughput

0.513

High

207093

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

0

High-throughput

0.513

High

207095

ERBIN
Erbin

1

0

High-throughput

0.513

High

207096

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.513

High

207098

PHB2
Prohibitin-2

1

0

High-throughput

0.513

High

207102

AFG2B
ATPase family gene 2 protein homolog B

1

0

High-throughput

0.513

High

207105

S22A4
Solute carrier family 22 member 4

1

0

High-throughput

0.513

High

207106

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.513

High

207112

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.513

High

207114

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.513

High

207115

JPH1
Junctophilin-1

1

0

High-throughput

0.513

High

207117

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

207118

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.513

High

207129

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.513

High

207130

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.513

High

207131

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

High-throughput

0.513

High

206998

TFF1
Trefoil factor 1

1

1

High-throughput

0.494

High

207067

ITIH5
Inter-alpha-trypsin inhibitor heavy chain H5

1

2

High-throughput

0.494

High

206982

CALU
Calumenin

1

2

High-throughput

0.489

High

207012

TRYB2
Tryptase beta-2

1

2

High-throughput

0.489

High

207052

RCN1
Reticulocalbin-1

1

2

High-throughput

0.489

High

207066

KTN1
Kinectin

1

2

High-throughput

0.489

High

207087

RCN3
Reticulocalbin-3

1

2

High-throughput

0.489

High

207100

RNF5
E3 ubiquitin-protein ligase RNF5

1

3

High-throughput

0.489

High

207133

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

207134

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

152922

RIOK3
Serine/threonine-protein kinase RIO3

1

1

High-throughput

0.479

High

162227

XPO1
Exportin-1

1

2

High-throughput

0.479

High

176514

FANCA
Fanconi anemia group A protein

1

2

Small-scale

0.479

High

207016

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

207038

RBM10
RNA-binding protein 10

1

2

High-throughput

0.479

High

207047

NCOA4
Nuclear receptor coactivator 4

1

1

High-throughput

0.479

High

207071

BAP18
Chromatin complexes subunit BAP18

1

1

High-throughput

0.479

High

207110

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

207058

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

73269

B4E1Q4
Serine/threonine-protein kinase RIO3

1

1

High-throughput

0.445

High

101722

F8W038
Chromosome 17 open reading frame 49

1

1

High-throughput

0.445

High

101759

F8W7C6
Large ribosomal subunit protein uL16

1

1

High-throughput

0.445

High

207101

DERL1
Derlin-1

1

1

High-throughput

0.437

High

207126

SSRG
Translocon-associated protein subunit gamma

1

1

High-throughput

0.437

High

206985

NEMF
Ribosome quality control complex subunit NEMF

1

0

High-throughput

0.426

High

73258

B4E1G1
Derlin

1

1

High-throughput

0.407

High

87330

C9JA28
Translocon-associated protein subunit gamma

1

1

High-throughput

0.407

High

207088

Q96E88
NCOA4 protein

1

1

High-throughput

0.407

High

146303

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

0

High-throughput

0.347

High

207039

UPAR
Urokinase plasminogen activator surface receptor

3

0

High-throughput

0.347

High

207051

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.328

High

207004

GROA
Growth-regulated alpha protein

1

0

High-throughput

0.282

High

207094

SG3A1
Secretoglobin family 3A member 1

1

0

High-throughput

0.282

High

207122

MRC2
C-type mannose receptor 2

1

0

High-throughput

0.282

High

207125

OSGI1
Oxidative stress-induced growth inhibitor 1

1

0

High-throughput

0.282

High

156422

SCAM3
Secretory carrier-associated membrane protein 3

1

0

High-throughput

0.279

Low

179133

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

206990

ERLN1
Erlin-1

1

0

High-throughput

0.279

Low

206993

FCN3
Ficolin-3

1

0

High-throughput

0.279

Low

207020

CD80
T-lymphocyte activation antigen CD80

1

0

High-throughput

0.279

Low

207021

APJ
Apelin receptor

1

0

High-throughput

0.279

Low

207027

PTH2R
Parathyroid hormone 2 receptor

1

0

High-throughput

0.279

Low

207037

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.279

Low

207044

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

207055

AAAT
Neutral amino acid transporter B(0)

1

0

High-throughput

0.279

Low

207063

INSY2
Inhibitory synaptic factor 2A

1

0

High-throughput

0.279

Low

207074

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

207084

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.279

Low

207085

SO4A1
Solute carrier organic anion transporter family member 4A1

1

0

High-throughput

0.279

Low

207119

MYOF
Myoferlin

1

0

High-throughput

0.279

Low

207135

CEPT1
Choline/ethanolaminephosphotransferase 1

1

0

High-throughput

0.279

Low

207043

SLAF1
Signaling lymphocytic activation molecule

1

0

High-throughput

0.249

Low

207109

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

207128

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

0

High-throughput

0.249

Low

207075

TOIP2
Torsin-1A-interacting protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024