HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: KC11 (P23291)
Casein kinase I homolog 1 (EC 2.7.11.1)
Gene: YCK1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	11805837, 37295430
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 705 Sc			1 538
+	Sc
		543790 HSC82_YEAST (1-705): 0: 977: 100.00		KC13_YEAST (57-506): 3.52e-167: 485: 48.37
+	Mm
		513660 HS90B_MOUSE (5-705): 0: 1025: 61.57		AKT1_MOUSE (30-416): 1.2e-122: 370: 14.39
+	Bt
		964601 HS90B_BOVIN (5-705): 0: 1022: 61.15		AKT1_BOVIN (30-417): 1.01e-123: 373: 14.61
+	Hs
		438633 HS90B_HUMAN (5-705): 0: 1022: 61.15		AKT3_HUMAN (12-421): 3.08e-123: 372: 14.35
+	Hs
		437928 HS90B_HUMAN (5-705): 0: 1022: 61.15		AKT2_HUMAN (24-416): 5.34e-123: 371: 15.21
+	Hs
		437991 HS90B_HUMAN (5-705): 0: 1022: 61.15		KC1E_HUMAN (62-486): 1.06e-123: 370: 38.35
+	Hs
		437927 HS90B_HUMAN (5-705): 0: 1022: 61.15		AKT1_HUMAN (30-416): 6.14e-122: 368: 14.39
+	Hs
		432376 HS90A_HUMAN (4-705): 0: 1013: 60.67		AKT3_HUMAN (12-421): 3.08e-123: 372: 14.35
+	Hs
		437984 HS90B_HUMAN (5-705): 0: 1022: 61.15		KC1A_HUMAN (54-387): 6.03e-122: 363: 49.40
+	Hs
		431573 HS90A_HUMAN (4-705): 0: 1013: 60.67		AKT2_HUMAN (24-416): 5.34e-123: 371: 15.21
+	Rn
		812703 HS90A_RAT (4-705): 0: 1014: 60.59		AKT1_RAT (30-416): 1.15e-122: 370: 14.39
+	Mm
		432411 HS90A_MOUSE (4-705): 0: 1012: 60.59		AKT1_MOUSE (30-416): 1.2e-122: 370: 14.39
+	Hs
		431572 HS90A_HUMAN (4-705): 0: 1013: 60.67		AKT1_HUMAN (30-416): 6.14e-122: 368: 14.39
+	Hs
		431646 HS90A_HUMAN (4-705): 0: 1013: 60.67		KC1A_HUMAN (54-387): 6.03e-122: 363: 49.40
+	Hs
		438069 HS90B_HUMAN (5-705): 0: 1022: 61.15		KC1G2_HUMAN (26-452): 1.54e-115: 349: 41.26
+	Hs
		431731 HS90A_HUMAN (4-705): 0: 1013: 60.67		KC1G2_HUMAN (26-452): 1.54e-115: 349: 41.26
+	Sc
		365822 HSP82_YEAST (1-705): 0: 968: 95.63		KC11_YEAST (1-538): 5.63e-129: 388: 100.00
+	Sc
		365823 HSP82_YEAST (1-705): 0: 968: 95.63		KC12_YEAST (5-538): 2.54e-122: 371: 65.94
+	Sc
		365925 HSP82_YEAST (1-705): 0: 968: 95.63		HRR25_YEAST (65-355): 3.9e-94: 297: 51.88
+	Hs
		538122 ENPL_HUMAN (3-680): 0: 893: 47.10		AKT1_HUMAN (30-416): 6.14e-122: 368: 14.39