HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: KCC1 (P27466)
Calcium/calmodulin-dependent protein kinase I (EC 2.7.11.17)
Gene: CMK1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	19536198
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 446
+	Hs
		438148 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC2D_HUMAN (31-446): 7.87e-140: 411: 29.59
+	Hs
		438631 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC2A_HUMAN (31-446): 1.93e-139: 409: 29.83
+	Hs
		431827 HS90A_HUMAN (4-705): 0: 1013: 60.67		KCC2D_HUMAN (31-446): 7.87e-140: 411: 29.59
+	Hs
		432373 HS90A_HUMAN (4-705): 0: 1013: 60.67		KCC2A_HUMAN (31-446): 1.93e-139: 409: 29.83
+	Hs
		438441 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC1G_HUMAN (34-380): 5.65e-130: 385: 35.23
+	Hs
		432166 HS90A_HUMAN (4-705): 0: 1013: 60.67		KCC1G_HUMAN (34-380): 5.65e-130: 385: 35.23
+	Sc
		543218 HSC82_YEAST (1-705): 0: 977: 100.00		KCC2_YEAST (27-432): 1.39e-134: 396: 59.61
+	Sc
		365813 HSP82_YEAST (1-705): 0: 968: 95.63		KCC2_YEAST (27-432): 1.39e-134: 396: 59.61
+	Zm
		24080 A0A1D6LMW9_MAIZE (2-680): 0: 834: 47.53		A0A1D6ICZ3_MAIZE (37-441): 1.25e-145: 427: 28.08
+	Hs
		438350 HS90B_HUMAN (5-705): 0: 1022: 61.15		DCLK2_HUMAN (35-365): 4.97e-55: 197: 33.82
+	Hs
		437842 HS90B_HUMAN (5-705): 0: 1022: 61.15		KPSH1_HUMAN (36-300): 1.29e-56: 194: 38.72
+	Hs
		438210 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC4_HUMAN (43-330): 3.61e-55: 192: 38.49
+	Hs
		432057 HS90A_HUMAN (4-705): 0: 1013: 60.67		DCLK2_HUMAN (35-365): 4.97e-55: 197: 33.82
+	Hs
		431475 HS90A_HUMAN (4-705): 0: 1013: 60.67		KPSH1_HUMAN (36-300): 1.29e-56: 194: 38.72
+	Hs
		431898 HS90A_HUMAN (4-705): 0: 1013: 60.67		KCC4_HUMAN (43-330): 3.61e-55: 192: 38.49
+	Hs
		438011 HS90B_HUMAN (5-705): 0: 1022: 61.15		KS6A3_HUMAN (1-242): 5.18e-33: 134: 34.80
+	Hs
		431672 HS90A_HUMAN (4-705): 0: 1013: 60.67		KS6A3_HUMAN (1-242): 5.18e-33: 134: 34.80