HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: VPS4 (P52917)
Vacuolar protein sorting-associated protein 4 (DOA4-independent degradation protein 6) (Protein END13) (Vacuolar protein-targeting protein 10)
Gene: VPS4

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31399574
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016887 - ATP hydrolysis activity
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 437
+	Hs
		260118 HS90B_HUMAN (5-705): 0: 1022: 61.15		VPS4B_HUMAN (2-436): 2.84e-118: 354: 60.50
+	Rn
		709240 HS90B_RAT (5-705): 0: 1025: 61.57		KTNA1_RAT (54-434): 1e-111: 339: 38.14
+	Rn
		948939 HS90A_RAT (4-705): 0: 1014: 60.59		KTNA1_RAT (54-434): 1e-111: 339: 38.14
+	Sc
		366599 HSP82_YEAST (1-705): 0: 968: 95.63		VPS4_YEAST (1-437): 9.44e-127: 375: 100.00
+	Hs
		265388 HS90A_HUMAN (4-705): 0: 1013: 60.67		KTNA1_HUMAN (75-434): 1.19e-104: 321: 38.59
+	Mm
		513673 HS90B_MOUSE (5-705): 0: 1025: 61.57		TERA_MOUSE (114-434): 1.72e-74: 250: 29.55
+	Hs
		438031 HS90B_HUMAN (5-705): 0: 1022: 61.15		TERA_HUMAN (114-434): 1.72e-74: 250: 29.55
+	Hs
		431695 HS90A_HUMAN (4-705): 0: 1013: 60.67		TERA_HUMAN (114-434): 1.72e-74: 250: 29.55
+	Sc
		543294 HSC82_YEAST (1-705): 0: 977: 100.00		CDC48_YEAST (114-435): 6.42e-75: 252: 28.57
+	Sc
		365885 HSP82_YEAST (1-705): 0: 968: 95.63		CDC48_YEAST (114-435): 6.42e-75: 252: 28.57
+	Dm
		1181188 Q9VAY2_DROME (3-676): 0: 833: 47.09		TERA_DROME (114-434): 1.15e-73: 248: 29.25