HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: IMB1 (Q06142)
Importin subunit beta-1 (Importin-95) (Karyopherin subunit beta-1) (Karyopherin-95)
Gene: KAP95

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	31399574, 37295430, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0097718 - disordered domain specific binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 861
+	Mm
		432420 HS90A_MOUSE (4-705): 0: 1012: 60.59		IMB1_MOUSE (4-857): 6.9e-166: 506: 33.07
+	Sc
		366915 HSP82_YEAST (1-705): 0: 968: 95.63		IMB1_YEAST (1-861): 3.78e-177: 534: 100.00
+	Ca
		804489 HSP90_CANAL (4-705): 0: 953: 82.36		Q59VX7_CANAL (4-852): 2.76e-164: 502: 49.94
+	Sc
		543372 HSC82_YEAST (1-705): 0: 977: 100.00		IMB3_YEAST (7-813): 1.96e-115: 379: 16.43
+	Sc
		365959 HSP82_YEAST (1-705): 0: 968: 95.63		IMB3_YEAST (7-813): 1.96e-115: 379: 16.43
+	Sc
		543821 HSC82_YEAST (1-705): 0: 977: 100.00		IMB4_YEAST (5-756): 1.06e-49: 192: 14.36
+	Sc
		366364 HSP82_YEAST (1-705): 0: 968: 95.63		IMB4_YEAST (5-756): 1.06e-49: 192: 14.36