HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: BRE1 (Q07457)
E3 ubiquitin-protein ligase BRE1 (EC 2.3.2.27) (Brefeldin A-sensitivity protein 1) (RING-type E3 ubiquitin transferase BRE1)
Gene: BRE1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.50	0.578

Property	Details
Experiments	37295430, 37230987, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 700
+	Hs
		256203 HS90B_HUMAN (5-705): 0: 1022: 61.15		BRE1B_HUMAN (315-700): 1.27e-34: 143: 20.73
+	Hs
		256202 HS90A_HUMAN (4-705): 0: 1013: 60.67		BRE1B_HUMAN (315-700): 1.27e-34: 143: 20.73
+	Sc
		366973 HSP82_YEAST (1-705): 0: 968: 95.63		BRE1_YEAST (1-700): 9.24e-50: 187: 100.00
+	Hs
		438138 HS90B_HUMAN (5-705): 0: 1022: 61.15		ROCK1_HUMAN (141-637): 1.52e-25: 115: 13.87
+	Hs
		148301 HS90B_HUMAN (5-705): 0: 1022: 61.15		CTRO_HUMAN (137-615): 1.43e-16: 86.6: 10.00
+	Hs
		437945 HS90B_HUMAN (5-705): 0: 1022: 61.15		MYH9_HUMAN (305-666): 1.45e-16: 86.6: 7.69
+	Hs
		431480 HS90A_HUMAN (4-705): 0: 1013: 60.67		MYH7_HUMAN (4-511): 1.08e-17: 90.1: 10.29
+	Hs
		148295 HS90A_HUMAN (4-705): 0: 1013: 60.67		CTRO_HUMAN (137-615): 1.43e-16: 86.6: 10.00
+	Hs
		431590 HS90A_HUMAN (4-705): 0: 1013: 60.67		MYH9_HUMAN (305-666): 1.45e-16: 86.6: 7.69
+	Hs
		538459 ENPL_HUMAN (3-680): 0: 893: 47.10		MRCKB_HUMAN (67-632): 1.66e-38: 156: 12.56
+	Sc
		365862 HSP82_YEAST (1-705): 0: 968: 95.63		USO1_YEAST (4-314): 6.54e-10: 64.7: 13.57
+	Hs
		148349 ENPL_HUMAN (3-680): 0: 893: 47.10		CTRO_HUMAN (137-615): 1.43e-16: 86.6: 10.00
+	Hs
		538356 ENPL_HUMAN (3-680): 0: 893: 47.10		RN185_HUMAN (648-699): 1.81e-11: 65.8: 29.63
+	Xl
		1140137 Q7ZTB3_XENLA (3-697): 0: 877: 46.54		Q5XGX4_XENLA (619-699): 7.06e-12: 66.9: 22.89