Protein: KAE1
tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (Kinase-associated endopeptidase 1) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1) (tRNA threonylcarbamoyladenosine biosynthesis protein KAE1)

Gene: KAE1
Organism: Saccharomyces cerevisiae S288C
Interactions: 81
UniProt ID: P36132

Gene Ontology (top 5):
GO:0000408 - EKC/KEOPS complex
GO:0000722 - telomere maintenance via recombination
GO:0000723 - telomere maintenance
GO:0000785 - chromatin
GO:0002949 - tRNA threonylcarbamoyladenosine modification

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

781974

PCC1
EKC/KEOPS complex subunit PCC1

3

0

Small-scale

0.796

High

781955

BUD32
EKC/KEOPS complex subunit BUD32

9

1

Small-scale

0.759

High

781960

CG121
EKC/KEOPS complex subunit CGI121

7

1

Small-scale

0.748

High

781945

GON7
EKC/KEOPS complex subunit GON7

7

0

Small-scale

0.717

High

740537

SUA5
Threonylcarbamoyl-AMP synthase

1

0

High-throughput

0.586

High

781921

KAE1
tRNA N6-adenosine threonylcarbamoyltransferase

1

3

Small-scale

0.575

High

781936

SSB2
Ribosome-associated molecular chaperone SSB2

2

4

High-throughput

0.552

High

544495

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.536

High

781927

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.536

High

781934

VHR2
Transcription factor VHR2

1

0

High-throughput

0.493

High

735422

TREA
Cytosolic neutral trehalase

1

1

High-throughput

0.479

High

762888

TREB
Probable trehalase

1

1

High-throughput

0.479

High

781937

TBP6
Probable 26S proteasome subunit YTA6

1

1

High-throughput

0.479

High

781949

CTF18
Chromosome transmission fidelity protein 18

1

1

High-throughput

0.479

High

781953

CUL3
Cullin-3

1

1

High-throughput

0.479

High

781958

ARP5
Actin-related protein 5

1

2

High-throughput

0.479

High

448303

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

0

High-throughput

0.458

High

575249

RAD4
DNA repair protein RAD4

1

0

High-throughput

0.458

High

594321

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

644619

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.458

High

677026

GID7
GID complex subunit 7

1

0

High-throughput

0.458

High

737139

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

1

0

High-throughput

0.458

High

746087

RAD5
DNA repair protein RAD5

1

0

High-throughput

0.458

High

781922

ERT1
Transcription activator of gluconeogenesis ERT1

1

0

High-throughput

0.458

High

781923

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.458

High

781924

TTL
Probable tubulin--tyrosine ligase PBY1

1

0

High-throughput

0.458

High

781925

YBY8
Uncharacterized protein YBR138C

1

0

High-throughput

0.458

High

781928

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

High-throughput

0.458

High

781929

ITS3
Phosphatidylinositol 4-phosphate 5-kinase MSS4

1

0

High-throughput

0.458

High

781932

UBP9
Ubiquitin carboxyl-terminal hydrolase 9

1

0

High-throughput

0.458

High

781933

PCL6
PHO85 cyclin-6

1

0

High-throughput

0.458

High

781938

RFC4
Replication factor C subunit 4

1

0

High-throughput

0.458

High

781939

ATG3
Autophagy-related protein 3

1

0

High-throughput

0.458

High

781941

MAD1
Spindle assembly checkpoint component MAD1

1

0

High-throughput

0.458

High

781942

THI6
Thiamine biosynthetic bifunctional enzyme [Includes: Thiamine-phosphate synthase

1

0

High-throughput

0.458

High

781943

T2FA
Transcription initiation factor IIF subunit alpha

1

0

High-throughput

0.458

High

781944

REF2
RNA end formation protein 2

1

0

High-throughput

0.458

High

781946

EAF6
Chromatin modification-related protein EAF6

1

0

High-throughput

0.458

High

781947

TTI2
TEL2-interacting protein 2

1

0

High-throughput

0.458

High

781948

TEA1
TY1 enhancer activator

1

0

High-throughput

0.458

High

781950

XRCC4
Non-homologous end-joining factor LIF1

1

0

High-throughput

0.458

High

781951

SDS23
Protein SDS23

1

0

High-throughput

0.458

High

781954

ATF2
Alcohol O-acetyltransferase 2

1

0

High-throughput

0.458

High

781956

DSL1
Protein transport protein DSL1

1

0

High-throughput

0.458

High

781961

EKI1
Ethanolamine kinase

1

0

High-throughput

0.458

High

781963

LCD1
DNA damage checkpoint protein LCD1

1

0

High-throughput

0.458

High

781966

MFG1
Morphogenetic regulator of filamentous growth protein 1

1

0

High-throughput

0.458

High

781970

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.458

High

781971

YL054
Uncharacterized transcriptional regulatory protein YLL054C

1

0

High-throughput

0.458

High

781972

NTO1
NuA3 HAT complex component NTO1

1

0

High-throughput

0.458

High

781973

TRM13
tRNA:m(4)X modification enzyme TRM13

1

0

High-throughput

0.458

High

781975

SEY1
Protein SEY1

1

0

High-throughput

0.458

High

392563

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.445

High

510389

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.445

High

523632

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

526419

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

579208

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.445

High

675911

MAS5
Mitochondrial protein import protein MAS5

1

4

High-throughput

0.445

High

726938

HS104
Heat shock protein 104

1

1

High-throughput

0.445

High

741370

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

752131

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

781931

XDJ1
DnaJ protein homolog XDJ1

1

4

High-throughput

0.445

High

781957

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.445

High

780094

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

1

High-throughput

0.437

High

781940

CHS6
Chitin biosynthesis protein CHS6

1

1

High-throughput

0.437

High

781969

BUD7
Bud site selection protein 7

1

1

High-throughput

0.437

High

358188

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.426

High

367736

ENO1
Enolase 1

1

0

High-throughput

0.426

High

781926

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.426

High

615274

ARGD
Acetylornithine aminotransferase, mitochondrial

1

0

High-throughput

0.249

Low

672234

CDC10
Cell division control protein 10

1

0

High-throughput

0.249

Low

781935

PEA2
Protein PEA2

1

0

High-throughput

0.249

Low

781952

SCW11
Probable family 17 glucosidase SCW11

1

0

High-throughput

0.249

Low

781959

EAR1
Protein EAR1

1

0

High-throughput

0.249

Low

781962

GPI17
GPI transamidase component GPI17

1

0

High-throughput

0.249

Low

781964

SPH1
Protein SPH1

1

0

High-throughput

0.249

Low

781965

MRX9
MIOREX complex component 9

1

0

High-throughput

0.249

Low

781967

SIL1
Nucleotide exchange factor SIL1

1

0

High-throughput

0.249

Low

781968

SDHF2
Succinate dehydrogenase assembly factor 2, mitochondrial

1

0

High-throughput

0.249

Low

781930

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025