HitPredict

Interactor 1: PVR (P15151)
Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155)
Gene: PVR

Interactor 2: CD226 (Q15762)
CD226 antigen (DNAX accessory molecule 1) (DNAM-1) (CD antigen CD226)
Gene: CD226

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.853

The method score is based on:

Property Details
Experiments 12913096, 30591568, 21982860
Identification Methods pull down, molecular sieving, surface plasmon resonance, protein array
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains C2-set_2~V-set, V-set~V-set
Common GO terms GO:0002860 - positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002891 - positive regulation of immunoglobulin mediated immune response
GO:0005886 - plasma membrane
GO:0009986 - cell surface
GO:0033005 - positive regulation of mast cell activation
and 3 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 417
Hs

1 336
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024