HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: VRK2 (Q86Y07)
Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2)
Gene: VRK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005635 - nuclear envelope GO:0005789 - endoplasmic reticulum membrane GO:0007165 - signal transduction GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 508
+	Hs
		925409 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00
+	Hs
		647868 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		925384 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73
+	Hs
		564418 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		564584 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73
+	Hs
		545213 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		545461 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73
+	Hs
		892467 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00
+	Hs
		951129 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00
+	Hs
		647855 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		892447 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73
+	Hs
		647872 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		951102 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73
+	Hs
		564425 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		AKT2_HUMAN (5-372): 9.14e-110: 336: 14.65
+	Hs
		568619 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		KAPCA_HUMAN (17-370): 7.42e-110: 331: 13.45
+	Hs
		925773 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		KC1G3_HUMAN (24-408): 2.13e-105: 323: 23.65
+	Hs
		821977 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		KC1A_HUMAN (17-366): 5.32e-106: 321: 24.72
+	Hs
		564761 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		KC1G3_HUMAN (24-408): 2.13e-105: 323: 23.65
+	Hs
		545731 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		KC1G3_HUMAN (24-408): 2.13e-105: 323: 23.65
+	Hs
		892707 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		KC1G3_HUMAN (24-408): 2.13e-105: 323: 23.65