HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: DOCK5 (Q9H7D0)
Dedicator of cytokinesis protein 5
Gene: DOCK5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DHR-2_Lobe_B~Ras, DHR-2_Lobe_C~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1870
+	Hs
		925620 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK5_HUMAN (1-1870): 0: 1989: 100.00
+	Mm
		925807 RAC1_MOUSE (1-192): 1.69e-84: 249: 92.19		DOCK1_MOUSE (1-1824): 0: 1945: 64.15
+	Hs
		925276 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK1_HUMAN (1-1714): 0: 1913: 67.23
+	Hs
		545372 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		DOCK1_HUMAN (1-1714): 0: 1913: 67.23
+	Hs
		925486 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK2_HUMAN (1-1825): 0: 1845: 54.97
+	Hs
		545535 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		DOCK2_HUMAN (1-1825): 0: 1845: 54.97
+	Hs
		925425 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK3_HUMAN (4-1866): 0: 1702: 35.05
+	Hs
		925429 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK4_HUMAN (4-1867): 0: 1688: 34.61
+	Dm
		776892 RAC1_DROME (1-192): 7.95e-82: 242: 89.06		Q8MQW7_DROME (683-1821): 0: 1050: 36.60
+	At
		1105136 RAC4_ARATH (4-177): 8.27e-80: 237: 64.94		SPK1_ARATH (174-1638): 0: 954: 14.70
+	At
		1105166 RAC5_ARATH (4-177): 3.51e-79: 236: 65.52		SPK1_ARATH (174-1638): 0: 954: 14.70
+	Hs
		925588 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK9_HUMAN (945-1640): 0: 706: 16.39
+	Hs
		564671 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		DOCK9_HUMAN (945-1640): 0: 706: 16.39
+	Hs
		545596 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		DOCK9_HUMAN (945-1640): 0: 706: 16.39
+	Hs
		925332 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOC11_HUMAN (945-1650): 0: 657: 15.01
+	Hs
		564557 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		DOC11_HUMAN (945-1650): 0: 657: 15.01
+	Hs
		545421 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		DOC11_HUMAN (945-1650): 0: 657: 15.01
+	Hs
		925518 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK6_HUMAN (945-1651): 3.45e-175: 586: 14.76
+	Hs
		925526 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK7_HUMAN (59-927): 2.15e-156: 533: 14.05
+	Hs
		925448 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		DOCK8_HUMAN (753-942): 5.88e-24: 112: 10.40