Protein: ITC1
Imitation switch two complex protein 1

Gene: ITC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 73
UniProt ID: P53125

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000781 - chromosome, telomeric region
GO:0005634 - nucleus
GO:0006338 - chromatin remodeling
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

917407

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

12

17

Small-scale

0.756

High

917404

DPB4
DNA polymerase epsilon subunit D

4

2

Small-scale

0.686

High

823465

DLS1
Protein DLS1

5

0

Small-scale

0.679

High

794198

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

3

17

High-throughput

0.667

High

381177

H2B1
Histone H2B.1

3

10

High-throughput

0.650

High

917400

NHP10
Non-histone protein 10

2

4

High-throughput

0.621

High

547879

NHP6B
Non-histone chromosomal protein 6B

2

3

High-throughput

0.588

High

382230

H4
Histone H4

2

3

High-throughput

0.571

High

419814

H2A2
Histone H2A.2

2

5

High-throughput

0.571

High

735790

TFC1
Transcription factor tau 95 kDa subunit

2

0

High-throughput

0.563

High

877587

RFX1
RFX-like DNA-binding protein RFX1

2

0

High-throughput

0.563

High

808765

NAB3
Nuclear polyadenylated RNA-binding protein 3

1

0

High-throughput

0.518

High

483794

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

High-throughput

0.513

High

850373

IOC3
ISWI one complex protein 3

1

0

High-throughput

0.513

High

917392

LSB1
LAS seventeen-binding protein 1

1

2

High-throughput

0.501

High

749702

TYE7
Transcription factor TYE7

1

1

High-throughput

0.481

High

755270

NUF2
Kinetochore protein NUF2

1

1

High-throughput

0.481

High

917393

AF9
Protein AF-9 homolog

1

1

High-throughput

0.481

High

381572

H2B2
Histone H2B.2

1

10

High-throughput

0.479

High

594479

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

734449

BTAF1
TATA-binding protein-associated factor MOT1

1

20

Small-scale

0.479

High

745817

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

917396

H3
Histone H3

1

8

Small-scale

0.479

High

641437

RCC1
Guanine nucleotide exchange factor SRM1

1

0

Small-scale

0.458

High

707689

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

763944

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

826673

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

916580

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

0

High-throughput

0.458

High

917394

ORC1
Origin recognition complex subunit 1

1

0

High-throughput

0.458

High

917397

CDC14
Tyrosine-protein phosphatase CDC14

1

0

Small-scale

0.458

High

917408

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

917410

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.458

High

393056

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.445

High

524609

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

527222

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

545622

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.445

High

547811

NHP6A
Non-histone chromosomal protein 6A

1

3

High-throughput

0.445

High

671540

SWI4
Regulatory protein SWI4

1

1

High-throughput

0.445

High

676181

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

736684

ASF1
Histone chaperone ASF1

1

1

High-throughput

0.445

High

742012

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

752979

IXR1
Intrastrand cross-link recognition protein

1

4

High-throughput

0.445

High

754168

MSN2
Zinc finger protein MSN2

1

2

High-throughput

0.445

High

781773

SET3
SET domain-containing protein 3

1

1

High-throughput

0.445

High

819309

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

917398

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

8

High-throughput

0.445

High

917405

RCO1
Transcriptional regulatory protein RCO1

1

8

High-throughput

0.445

High

917409

CAF1A
Chromatin assembly factor 1 subunit A

1

1

High-throughput

0.445

High

917411

H2AZ
Histone H2A.Z

1

5

High-throughput

0.445

High

753121

NIP80
Protein NIP100

1

2

High-throughput

0.439

High

917406

YET3
Endoplasmic reticulum transmembrane protein 3

1

2

High-throughput

0.439

High

550066

RAP1
DNA-binding protein RAP1

1

0

High-throughput

0.426

High

649992

SIN3
Transcriptional regulatory protein SIN3

1

0

High-throughput

0.426

High

727193

HS104
Heat shock protein 104

1

0

High-throughput

0.426

High

737643

HIR1
Protein HIR1

1

0

High-throughput

0.426

High

804310

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

820427

RT106
Histone chaperone RTT106

1

0

High-throughput

0.426

High

823005

ATAD2
ATPase histone chaperone YTA7

1

0

High-throughput

0.426

High

917395

MOT3
Transcriptional activator/repressor MOT3

1

0

High-throughput

0.426

High

917401

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.426

High

917402

YHP1
Homeobox protein YHP1

1

0

High-throughput

0.426

High

816315

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.407

High

826456

DJP1
DnaJ-like protein 1

1

2

High-throughput

0.407

High

850323

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

0

High-throughput

0.282

High

917399

YD541
Putative uncharacterized oxidoreductase YDR541C

1

0

High-throughput

0.282

High

917412

YC021
Putative uncharacterized protein YCL021W-A

1

0

High-throughput

0.282

High

672434

STE50
Protein STE50

1

0

High-throughput

0.269

Low

781330

DID4
DOA4-independent degradation protein 4

1

0

High-throughput

0.251

Low

804905

LAM4
Membrane-anchored lipid-binding protein LAM4

1

0

High-throughput

0.251

Low

849827

BUD27
Bud site selection protein 27

1

0

High-throughput

0.251

Low

800668

KPR2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.249

Low

863662

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

917403

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025