HitPredict

Interactor 1: EZRI (P15311)
Ezrin (Cytovillin) (Villin-2) (p81)
Gene: EZR

Interactor 2: PACE1 (Q8IZE3)
Protein-associating with the carboxyl-terminal domain of ezrin (Ezrin-binding protein PACE-1) (SCY1-like protein 3)
Gene: SCYL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	12651155, 34079125, 32707033
Identification Methods	two hybrid, proximity labelling technology, affinity chromatography technology, confocal microscopy, pull down
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 586 Hs			1 742
+	Hs
		546938 EZRI_HUMAN (1-586): 5.67e-178: 517: 100.00		MARK3_HUMAN (2-590): 9.3e-123: 386: 11.03
+	Hs
		547111 EZRI_HUMAN (1-586): 5.67e-178: 517: 100.00		MARK2_HUMAN (2-672): 1.7e-114: 365: 11.68
+	Hs
		647967 E41LA_HUMAN (1-576): 5.03e-116: 361: 16.47		MARK3_HUMAN (2-590): 9.3e-123: 386: 11.03
+	Hs
		1039169 E41LB_HUMAN (4-554): 6.81e-121: 380: 17.59		KCC2D_HUMAN (5-516): 1.03e-113: 354: 12.43
+	Hs
		1183129 E41LA_HUMAN (1-576): 5.03e-116: 361: 16.47		MARK2_HUMAN (2-672): 1.7e-114: 365: 11.68