Protein: ACAC
Acetyl-CoA carboxylase (ACC) (EC 6.4.1.2) (Fatty acid synthetase 3) (mRNA transport-defective protein 7) [Includes: Biotin carboxylase (EC 6.3.4.14)]

Gene: ACAC, ACC1
Organism: Saccharomyces cerevisiae S288C
Interactions: 153
UniProt ID: Q00955

Gene Ontology (top 5):
GO:0003989 - acetyl-CoA carboxylase activity
GO:0004075 - biotin carboxylase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1028015

ACAC
Acetyl-CoA carboxylase

3

15

Small-scale

0.821

High

633501

PP11
Serine/threonine-protein phosphatase PP1-1

4

5

High-throughput

0.699

High

746522

HFA1
Acetyl-CoA carboxylase, mitochondrial

1

16

High-throughput

0.665

High

393185

HSP82
ATP-dependent molecular chaperone HSP82

3

11

High-throughput

0.640

High

823633

TCPE
T-complex protein 1 subunit epsilon

2

3

High-throughput

0.628

High

675301

DMC1
Meiotic recombination protein DMC1

2

5

Small-scale

0.614

High

671022

SIS1
Protein SIS1

2

7

High-throughput

0.601

High

727251

HS104
Heat shock protein 104

2

6

High-throughput

0.584

High

579906

HSC82
ATP-dependent molecular chaperone HSC82

2

11

High-throughput

0.571

High

524865

HSP71
Heat shock protein SSA1

2

16

High-throughput

0.552

High

527443

HSP72
Heat shock protein SSA2

2

16

High-throughput

0.552

High

545925

SSB1
Ribosome-associated molecular chaperone SSB1

2

18

High-throughput

0.552

High

819524

SSB2
Ribosome-associated molecular chaperone SSB2

2

18

High-throughput

0.552

High

792436

BOI1
BEM1-interacting protein 1

1

2

High-throughput

0.541

High

1028028

MYO5
Myosin-5

1

1

High-throughput

0.541

High

778888

PTK1
Serine/threonine-protein kinase PTK1/STK1

1

9

High-throughput

0.536

High

779434

MAOM
NAD-dependent malic enzyme, mitochondrial

1

2

High-throughput

0.536

High

923104

BRE5
UBP3-associated protein BRE5

1

3

High-throughput

0.536

High

924282

RM22
Large ribosomal subunit protein uL22m

1

2

High-throughput

0.536

High

1028016

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

8

High-throughput

0.536

High

1028027

KU80
ATP-dependent DNA helicase II subunit 2

1

2

High-throughput

0.536

High

1028036

SHS1
Seventh homolog of septin 1

1

3

High-throughput

0.536

High

1028048

SKS1
Serine/threonine-protein kinase SKS1

1

7

High-throughput

0.536

High

1028042

AP3D
AP-3 complex subunit delta

2

3

Small-scale

0.535

High

826748

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.533

High

803371

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

5

High-throughput

0.494

High

805425

BZZ1
Protein BZZ1

1

1

High-throughput

0.494

High

864740

BBC1
Myosin tail region-interacting protein MTI1

1

2

High-throughput

0.494

High

823332

YJH0
Inactive deaminase YJL070C

1

0

High-throughput

0.493

High

459145

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

5

High-throughput

0.489

High

836847

MPG1
Mannose-1-phosphate guanyltransferase

1

3

High-throughput

0.489

High

893325

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

3

High-throughput

0.489

High

1028026

UTP5
U3 small nucleolar RNA-associated protein 5

1

8

High-throughput

0.489

High

554725

YPK1
Serine/threonine-protein kinase YPK1

1

9

Small-scale

0.481

High

676965

SRO9
RNA-binding protein SRO9

1

4

Small-scale

0.481

High

744149

BRR2
Pre-mRNA-splicing helicase BRR2

1

1

Small-scale

0.481

High

757844

PP2C3
Protein phosphatase 2C homolog 3

1

2

Small-scale

0.481

High

804785

NADE
Glutamine-dependent NAD(+) synthetase

1

1

Small-scale

0.481

High

815996

VAC8
Vacuolar protein 8

1

2

Small-scale

0.481

High

1028018

OSH6
Oxysterol-binding protein homolog 6

1

1

Small-scale

0.481

High

149901

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

383843

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.479

High

402086

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.479

High

410284

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

430905

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

4

Small-scale

0.479

High

433795

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.479

High

435290

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

436109

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

438754

SC160
Protein SCP160

1

2

High-throughput

0.479

High

442060

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

455209

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

503186

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

504365

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

512592

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.479

High

514778

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

518368

IF4A
ATP-dependent RNA helicase eIF4A

1

5

High-throughput

0.479

High

645199

PSB4
Proteasome subunit beta type-4

1

1

Small-scale

0.479

High

674776

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

679974

CDC48
Cell division control protein 48

1

8

High-throughput

0.479

High

689105

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.479

High

689605

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

747523

RSSA1
Small ribosomal subunit protein uS2A

1

4

High-throughput

0.479

High

747999

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

753528

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.479

High

778481

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

781723

SA190
SIT4-associating protein SAP190

1

5

High-throughput

0.479

High

802326

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

812104

DHH1
ATP-dependent RNA helicase DHH1

1

5

High-throughput

0.479

High

812569

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

823019

ATAD2
ATPase histone chaperone YTA7

1

10

High-throughput

0.479

High

844576

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.479

High

864805

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.479

High

865703

MOG1
Nuclear import protein MOG1

1

3

High-throughput

0.479

High

874470

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

918654

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

925365

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

932212

ORC1
Origin recognition complex subunit 1

1

4

High-throughput

0.479

High

1025003

NUM1
Nuclear migration protein NUM1

1

3

High-throughput

0.479

High

1028017

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

1028020

MLP1
Protein MLP1

1

3

High-throughput

0.479

High

1028024

RUVB1
RuvB-like protein 1

1

6

High-throughput

0.479

High

1028031

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.479

High

1028038

MCA1
Metacaspase-1

1

2

High-throughput

0.479

High

1028041

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.479

High

1028043

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

1028046

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

2

Small-scale

0.479

High

1028047

RUVB2
RuvB-like protein 2

1

6

High-throughput

0.479

High

1028049

SMC6
Structural maintenance of chromosomes protein 6

1

8

High-throughput

0.479

High

444598

DED1
ATP-dependent RNA helicase DED1

1

0

Small-scale

0.460

High

661428

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.460

High

792687

RIB1
GTP cyclohydrolase-2

1

0

Small-scale

0.460

High

836384

THI6
Thiamine biosynthetic bifunctional enzyme [Includes: Thiamine-phosphate synthase

1

0

Small-scale

0.460

High

1028030

SVF1
Ceramide-binding protein SVF1

1

0

Small-scale

0.460

High

1028039

FOLE
Folylpolyglutamate synthase

1

0

Small-scale

0.460

High

780051

EAP1
Protein EAP1

1

0

High-throughput

0.458

High

804821

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.458

High

1028022

ESP1
Separin

1

0

High-throughput

0.458

High

739902

RPD3
Histone deacetylase RPD3

1

15

Small-scale

0.457

High

386826

TBB
Tubulin beta chain

1

5

High-throughput

0.445

High

810745

TCPB
T-complex protein 1 subunit beta

1

3

High-throughput

0.445

High

394826

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

510733

HSP77
Import motor subunit, mitochondrial

1

10

High-throughput

0.445

High

592440

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.445

High

597753

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

1

High-throughput

0.445

High

646152

NPR1
Nitrogen permease reactivator protein

1

11

High-throughput

0.445

High

676267

MAS5
Mitochondrial protein import protein MAS5

1

4

High-throughput

0.445

High

692420

KCC1
Calcium/calmodulin-dependent protein kinase I

1

1

High-throughput

0.445

High

742191

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

752615

HSP78
Heat shock protein 78, mitochondrial

1

6

High-throughput

0.445

High

824520

6P21
6-phosphofructo-2-kinase 1

1

1

High-throughput

0.445

High

871442

HLJ1
Protein HLJ1

1

5

High-throughput

0.445

High

732784

CHMU
Chorismate mutase

1

1

Small-scale

0.439

High

820340

VID27
Vacuolar import and degradation protein 27

1

1

Small-scale

0.439

High

382282

H4
Histone H4

1

6

High-throughput

0.437

High

558835

CAF20
Cap-associated protein CAF20

1

4

High-throughput

0.437

High

676667

SGF29
SAGA complex subunit SGF29

1

1

Small-scale

0.437

High

707919

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.437

High

709930

BMH1
Protein BMH1

1

5

High-throughput

0.437

High

779315

CENPA
Histone H3-like centromeric protein CSE4

1

3

High-throughput

0.437

High

797773

AIM4
Altered inheritance of mitochondria protein 4

1

1

High-throughput

0.437

High

803161

ECM29
Proteasome component ECM29

1

2

High-throughput

0.437

High

808883

UME6
Transcriptional regulatory protein UME6

1

4

High-throughput

0.437

High

824928

TM108
Protein TMA108

1

3

High-throughput

0.437

High

827582

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

871521

HGH1
Protein HGH1

1

1

Small-scale

0.437

High

877881

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

918953

PESC
Pescadillo homolog

1

1

High-throughput

0.437

High

963651

H3
Histone H3

1

3

High-throughput

0.437

High

1025790

RAGAB
GTP-binding protein GTR1

1

1

Small-scale

0.437

High

1028023

TOM1
E3 ubiquitin-protein ligase TOM1

1

12

High-throughput

0.437

High

1028032

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.437

High

1028037

SGO1
Shugoshin

1

1

High-throughput

0.437

High

1028045

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.437

High

835082

SYS1
Protein SYS1

1

0

High-throughput

0.426

High

1028021

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.426

High

671687

SCJ1
DnaJ-related protein SCJ1

1

3

High-throughput

0.407

High

753260

MFT1
THO complex subunit MFT1

1

1

High-throughput

0.407

High

807256

SPT8
SAGA complex subunit SPT8

1

1

High-throughput

0.407

High

1028019

ADA2
SAGA complex subunit ADA2

1

2

High-throughput

0.407

High

1028034

SSK1
Osmolarity two-component system protein SSK1

1

1

High-throughput

0.407

High

1010265

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.282

High

1028035

CYK3
Cytokinesis protein 3

1

0

High-throughput

0.282

High

1028029

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.279

Low

1028033

VAC14
Vacuole morphology and inheritance protein 14

1

0

High-throughput

0.279

Low

1027978

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

0

High-throughput

0.265

Low

561198

PYRE
Orotate phosphoribosyltransferase 1

1

0

Small-scale

0.251

Low

923851

GIS2
Zinc finger protein GIS2

1

0

Small-scale

0.251

Low

1028040

RPN8
26S proteasome regulatory subunit RPN8

1

0

Small-scale

0.251

Low

844696

SET4
SET domain-containing protein 4

1

0

Small-scale

0.249

Low

1028025

SND1
SRP-independent targeting protein 1

1

0

High-throughput

0.249

Low

912431

PFD6
Prefoldin subunit 6

1

0

High-throughput

0.232

Low

1028044

NSL1
Kinetochore-associated protein NSL1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025