HitPredict

Interactor 1: EZRI (P15311)
Ezrin (Cytovillin) (Villin-2) (p81)
Gene: EZR

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	38280479
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 586 Hs			1 400
+	Hs
		546968 EZRI_HUMAN (1-586): 5.67e-178: 517: 100.00		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		719609 MERL_HUMAN (2-586): 3.18e-146: 436: 44.37		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Hs
		505678 EPB41_HUMAN (3-553): 9.55e-129: 400: 22.99		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Hs
		547209 EZRI_HUMAN (1-586): 5.67e-178: 517: 100.00		WWP1_HUMAN (3-386): 5.05e-64: 222: 13.86
+	Hs
		719410 MERL_HUMAN (2-586): 3.18e-146: 436: 44.37		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		505580 EPB41_HUMAN (3-553): 9.55e-129: 400: 22.99		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		204630 E41L2_HUMAN (2-577): 1.05e-117: 374: 19.70		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		640152 MOES_HUMAN (1-586): 4.45e-161: 474: 72.70		SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62
+	Hs
		125188 MERL_HUMAN (2-586): 3.18e-146: 436: 44.37		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Hs
		546967 EZRI_HUMAN (1-586): 5.67e-178: 517: 100.00		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00
+	Hs
		719536 MERL_HUMAN (2-586): 3.18e-146: 436: 44.37		KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88
+	Hs
		719615 MERL_HUMAN (2-586): 3.18e-146: 436: 44.37		SAV1_HUMAN (2-252): 3.57e-48: 169: 15.89
+	Hs
		505658 EPB41_HUMAN (3-553): 9.55e-129: 400: 22.99		KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88
+	Dm
		1098312 MERH_DROME (3-586): 1.08e-131: 400: 40.58		KIBRA_DROME (122-260): 5.04e-43: 162: 21.58
+	Dm
		2636 MERH_DROME (3-586): 1.08e-131: 400: 40.58		A0A0B4LH59_DROME (122-260): 5.04e-43: 162: 21.58
+	Hs
		1336123 E41L3_HUMAN (2-466): 2.17e-114: 367: 22.83		SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62
+	Hs
		204697 E41L2_HUMAN (2-577): 1.05e-117: 374: 19.70		KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88
+	Hs
		1220100 E41L3_HUMAN (2-466): 2.17e-114: 367: 22.83		KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88
+	Hs
		299270 FARP2_HUMAN (2-548): 8.98e-114: 365: 19.42		KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88
+	Hs
		719588 MERL_HUMAN (2-586): 3.18e-146: 436: 44.37		NED4L_HUMAN (164-352): 3.03e-13: 73.5: 13.20