HitPredict

Interactor 1: IRF1 (P15314)
Interferon regulatory factor 1 (IRF-1)
Gene: IRF1

Interactor 2: CCL5 (P30882)
C-C motif chemokine 5 (MuRantes) (SIS-delta) (Small-inducible cytokine A5) (T-cell-specific protein RANTES)
Gene: CCL5

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	15860458, 16707500, 10926836, 21036898
Identification Methods	electrophoretic mobility shift assay, anti tag coimmunoprecipitation, electrophoretic mobility supershift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0071347 - cellular response to interleukin-1 GO:0071356 - cellular response to tumor necrosis factor
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 329 Mm			1 91
+	Hs
		500980 IRF1_HUMAN (1-329): 5.33e-176: 491: 84.50		CCL5_HUMAN (1-91): 3.6e-30: 103: 80.22
+	Hs
		501084 IRF1_HUMAN (1-329): 5.33e-176: 491: 84.50		CCL19_HUMAN (17-91): 4.23e-21: 81.2: 32.47
+	Mm
		618899 IRF8_MOUSE (7-199): 2.28e-54: 184: 29.02		CCL5_MOUSE (1-91): 5.13e-35: 116: 100.00
+	Hs
		962721 IRF9_HUMAN (7-154): 1e-60: 200: 33.97		CCL19_HUMAN (17-91): 4.23e-21: 81.2: 32.47
+	Mm
		618889 IRF8_MOUSE (7-199): 2.28e-54: 184: 29.02		CCL6_MOUSE (1-90): 9.35e-27: 96.2: 25.23
+	Hs
		528263 IRF3_HUMAN (1-161): 5.39e-50: 173: 27.95		CCL5_HUMAN (1-91): 3.6e-30: 103: 80.22
+	Hs
		1039468 IRF5_HUMAN (2-125): 5.71e-51: 178: 40.95		CCL19_HUMAN (17-91): 4.23e-21: 81.2: 32.47
+	Hs
		1056458 IRF3_HUMAN (1-161): 5.39e-50: 173: 27.95		CCL19_HUMAN (17-91): 4.23e-21: 81.2: 32.47
+	Hs
		528273 IRF7_HUMAN (4-111): 8.86e-37: 139: 30.77		CCL5_HUMAN (1-91): 3.6e-30: 103: 80.22
+	Hs
		1273342 IRF7_HUMAN (4-111): 8.86e-37: 139: 30.77		CCL19_HUMAN (17-91): 4.23e-21: 81.2: 32.47