HitPredict

Interactor 1: TOP2 (P15348)
DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)
Gene: TOP2

Interactor 2: TOP2 (P15348)
DNA topoisomerase 2 (EC 5.6.2.2) (DNA topoisomerase II)
Gene: TOP2

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.647

The method score is based on:

Property Details
Experiments 11447119
Identification Methods pull down
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains DNA_gyraseB~DNA_gyraseB, DNA_gyraseB~DNA_topoisoIV, DNA_gyraseB~HATPase_c, DNA_gyraseB~Toprim, DNA_topoisoIV~DNA_topoisoIV, DNA_topoisoIV~Toprim, DNA_topoisoIV~TOPRIM_C, HATPase_c~HATPase_c, Toprim~Toprim, TOPRIM_C~Toprim
Common GO terms GO:0000070 - mitotic sister chromatid segregation
GO:0000182 - rDNA binding
GO:0000278 - mitotic cell cycle
GO:0000400 - four-way junction DNA binding
GO:0000712 - resolution of meiotic recombination intermediates
and 19 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 1447
Dm

1 1447
+ Hs
+ Hs
+ Zm
+ Sc
+ Ec
+ Mp
+ At
+ Mp
+ Sp
+ Mp
+ Ec
+ Ec
+ Ec
+ Ec
+ Ec
+ Hp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024