HitPredict

Interactor 1: VAV (P15498)
Proto-oncogene vav
Gene: VAV1

Interactor 2: CDC42 (P60953)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.840

Property	Details
Experiments	11287617, 32203420, 18511940
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer, fluorescence technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	C1_1~Ras, PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0007229 - integrin-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 845 Hs			1 191
+	Hs
		548678 VAV_HUMAN (1-845): 0: 641: 100.00		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		548672 VAV_HUMAN (1-845): 0: 641: 100.00		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		925718 VAV3_HUMAN (1-840): 0: 601: 57.31		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		951449 VAV3_HUMAN (1-840): 0: 601: 57.31		RHOG_HUMAN (1-191): 7.59e-82: 242: 60.73
+	Hs
		901037 VAV3_HUMAN (1-840): 0: 601: 57.31		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		855782 VAV2_HUMAN (1-839): 0: 562: 47.14		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Hs
		855778 VAV2_HUMAN (1-839): 0: 562: 47.14		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		855779 VAV2_HUMAN (1-839): 0: 562: 47.14		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Ce
		975575 VAV_CAEEL (2-842): 7.35e-123: 396: 22.68		RAC1_CAEEL (1-191): 5.53e-85: 250: 65.97
+	Ce
		104467 VAV_CAEEL (2-842): 7.35e-123: 396: 22.68		G5EBV3_CAEEL (2-191): 1e-81: 242: 58.95
+	Dm
		776903 VAV_DROME (2-574): 2.3e-114: 368: 33.17		RAC1_DROME (1-191): 1.02e-81: 242: 69.27
+	Hs
		50555 PKHG3_HUMAN (183-669): 1.25e-79: 281: 20.81		RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94
+	Hs
		50580 PKHG3_HUMAN (183-669): 1.25e-79: 281: 20.81		RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31
+	Sc
		509398 CDC24_YEAST (23-475): 1.72e-84: 290: 20.00		CDC42_YEAST (1-191): 2.69e-80: 238: 80.11
+	Hs
		894320 FGD4_HUMAN (45-576): 1.08e-82: 283: 15.28		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		50572 PKHG3_HUMAN (183-669): 1.25e-79: 281: 20.81		CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00
+	Hs
		50573 PKHG3_HUMAN (183-669): 1.25e-79: 281: 20.81		RHOA_HUMAN (5-191): 3.88e-81: 240: 53.48
+	Hs
		50554 PKHG3_HUMAN (183-669): 1.25e-79: 281: 20.81		RAC2_HUMAN (1-191): 1.49e-80: 239: 68.75
+	Hs
		50546 PKHG3_HUMAN (183-669): 1.25e-79: 281: 20.81		RHOC_HUMAN (5-191): 3.64e-79: 235: 52.41
+	Hs
		50571 PKHG3_HUMAN (183-669): 1.25e-79: 281: 20.81		RAC3_HUMAN (1-177): 2.36e-78: 233: 72.32