HitPredict

Interactor 1: VAV (P15498)
Proto-oncogene vav
Gene: VAV1

Interactor 2: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	32203420, 18511940
Identification Methods	fluorescent resonance energy transfer, fluorescence technology
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~Ras, PH~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 845 Hs			1 193
+	Hs
		548678 VAV_HUMAN (1-845): 0: 641: 100.00		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		548671 VAV_HUMAN (1-845): 0: 641: 100.00		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		901037 VAV3_HUMAN (1-840): 0: 601: 57.31		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		925718 VAV3_HUMAN (1-840): 0: 601: 57.31		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		951449 VAV3_HUMAN (1-840): 0: 601: 57.31		RHOG_HUMAN (1-193): 2.83e-77: 231: 54.40
+	Hs
		855779 VAV2_HUMAN (1-839): 0: 562: 47.14		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		855782 VAV2_HUMAN (1-839): 0: 562: 47.14		RAC1_HUMAN (1-193): 8.86e-80: 237: 57.22
+	Hs
		855778 VAV2_HUMAN (1-839): 0: 562: 47.14		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Ce
		975575 VAV_CAEEL (2-842): 7.35e-123: 396: 22.68		RAC1_CAEEL (1-193): 2.07e-80: 238: 55.44
+	Ce
		104467 VAV_CAEEL (2-842): 7.35e-123: 396: 22.68		G5EBV3_CAEEL (2-193): 1.08e-77: 232: 50.52
+	Ce
		1094614 VAV_CAEEL (2-842): 7.35e-123: 396: 22.68		RHO1_CAEEL (1-192): 2.25e-75: 226: 85.94
+	Dm
		776903 VAV_DROME (2-574): 2.3e-114: 368: 33.17		RAC1_DROME (1-193): 2.11e-77: 231: 54.12
+	Hs
		50573 PKHG3_HUMAN (183-669): 1.25e-79: 281: 20.81		RHOA_HUMAN (1-193): 1.4e-80: 239: 100.00
+	Hs
		50546 PKHG3_HUMAN (183-669): 1.25e-79: 281: 20.81		RHOC_HUMAN (1-193): 3.04e-78: 233: 91.71
+	Sc
		509398 CDC24_YEAST (23-475): 1.72e-84: 290: 20.00		CDC42_YEAST (1-193): 2.09e-74: 223: 50.26
+	Hs
		894320 FGD4_HUMAN (45-576): 1.08e-82: 283: 15.28		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		50572 PKHG3_HUMAN (183-669): 1.25e-79: 281: 20.81		CDC42_HUMAN (1-193): 5.51e-77: 230: 52.33
+	Hs
		50554 PKHG3_HUMAN (183-669): 1.25e-79: 281: 20.81		RAC2_HUMAN (1-193): 3.9e-76: 228: 53.61
+	Hs
		50571 PKHG3_HUMAN (183-669): 1.25e-79: 281: 20.81		RAC3_HUMAN (1-179): 4.85e-74: 223: 57.54
+	Hs
		50535 PKHG3_HUMAN (183-669): 1.25e-79: 281: 20.81		RHOD_HUMAN (7-182): 1.68e-69: 212: 53.98