Protein: PYRG1
CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1)

Gene: PYRG1, CTPS1
Organism: Homo sapiens
Interactions: 162
UniProt ID: P17812

Gene Ontology (top 5):
GO:0003883 - CTP synthase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006139 - nucleobase-containing compound metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

608198

PYRG2
CTP synthase 2

7

9

High-throughput

0.961

High

608083

PYRG1
CTP synthase 1

3

9

High-throughput

0.861

High

371103

MYC
Myc proto-oncogene protein

4

1

High-throughput

0.686

High

563145

CFTR
Cystic fibrosis transmembrane conductance regulator

3

1

High-throughput

0.662

High

608128

CUL3
Cullin-3

2

5

High-throughput

0.611

High

608168

CSN5
COP9 signalosome complex subunit 5

2

3

High-throughput

0.611

High

240690

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

608145

TIGD3
Tigger transposable element-derived protein 3

2

1

High-throughput

0.574

High

608103

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

3

High-throughput

0.571

High

608113

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

2

4

Small-scale

0.571

High

608143

FTM
Protein fantom

2

1

High-throughput

0.571

High

608185

MLP3B
Microtubule-associated protein 1 light chain 3 beta

2

4

Small-scale

0.571

High

608195

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

2

0

High-throughput

0.559

High

289922

OFD1
Centriole and centriolar satellite protein OFD1

2

0

High-throughput

0.547

High

608173

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

249565

SNX3
Sorting nexin-3

1

1

High-throughput

0.536

High

581428

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

3

High-throughput

0.536

High

608108

MAP2
Methionine aminopeptidase 2

1

1

High-throughput

0.536

High

608126

CUL1
Cullin-1

1

5

High-throughput

0.536

High

608127

CUL2
Cullin-2

1

5

High-throughput

0.536

High

608129

CUL4B
Cullin-4B

1

5

High-throughput

0.536

High

608153

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

High-throughput

0.536

High

608162

NEK7
Serine/threonine-protein kinase Nek7

1

1

High-throughput

0.536

High

608169

CUL5
Cullin-5

1

5

High-throughput

0.536

High

608154

LCA5
Lebercilin

2

1

High-throughput

0.521

High

165697

PPE1
Serine/threonine-protein phosphatase with EF-hands 1

1

0

High-throughput

0.513

High

578629

GLNA
Glutamine synthetase

1

0

High-throughput

0.513

High

608094

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.513

High

608097

VATE1
V-type proton ATPase subunit E 1

1

0

High-throughput

0.513

High

608112

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.513

High

608136

NEDD8
Ubiquitin-like protein NEDD8

1

0

High-throughput

0.513

High

608161

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

608177

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

608184

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.513

High

608088

1433T
14-3-3 protein theta

1

5

High-throughput

0.501

High

608084

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.493

High

608101

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

608209

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.493

High

608155

SUGP1
SURP and G-patch domain-containing protein 1

1

1

High-throughput

0.489

High

141314

DDX3X
ATP-dependent RNA helicase DDX3X

1

2

Small-scale

0.479

High

247226

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

1

High-throughput

0.479

High

315090

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

325677

UBR5
E3 ubiquitin-protein ligase UBR5

1

1

Small-scale

0.479

High

379864

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.479

High

411313

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

520740

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.479

High

536454

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

606182

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

608086

CDK2
Cyclin-dependent kinase 2

1

3

High-throughput

0.479

High

608091

PML
Protein PML

1

3

High-throughput

0.479

High

608092

1433B
14-3-3 protein beta/alpha

1

5

High-throughput

0.479

High

608100

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

608107

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

608110

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.479

High

608111

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

608114

1433G
14-3-3 protein gamma

1

5

High-throughput

0.479

High

608115

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

608116

1433Z
14-3-3 protein zeta/delta

1

5

High-throughput

0.479

High

608119

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

608130

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

608134

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

608135

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

608148

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

608158

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

608164

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

608166

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

608175

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

608179

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

608186

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

608190

TXNIP
Thioredoxin-interacting protein

1

1

Small-scale

0.479

High

608192

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

608194

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.479

High

169935

AURKA
Aurora kinase A

1

0

High-throughput

0.458

High

238379

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

258420

EDF1
Endothelial differentiation-related factor 1

1

0

High-throughput

0.458

High

293165

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

294823

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

0

High-throughput

0.458

High

319374

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

345342

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

349781

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

352747

F107A
Actin-associated protein FAM107A

1

0

High-throughput

0.458

High

608087

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

608093

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

608095

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

608098

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

608099

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

608102

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

608106

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

608109

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.458

High

608117

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

608118

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

608120

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.458

High

608121

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

608122

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

608124

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

608125

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

608132

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

608133

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

0

High-throughput

0.458

High

608141

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

608142

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

608144

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

608146

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

608149

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

608151

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

608152

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

608157

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.458

High

608160

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

608163

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

608170

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

608172

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.458

High

608174

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

608182

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

608183

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.458

High

608193

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

608196

ANLN
Anillin

1

0

High-throughput

0.458

High

608197

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

608200

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

608201

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

608202

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

608204

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

608208

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

327788

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

4

High-throughput

0.445

High

608090

GRN
Progranulin

1

1

High-throughput

0.445

High

608188

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

4

High-throughput

0.445

High

608189

SPNS1
Protein spinster homolog 1

1

1

High-throughput

0.445

High

608191

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

4

High-throughput

0.445

High

405770

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

587868

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

608089

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

608096

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

608104

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

608123

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.437

High

608137

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

608150

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

608165

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

608167

DPF3
Zinc finger protein DPF3

1

1

Small-scale

0.437

High

608176

CIC
Protein capicua homolog

1

1

High-throughput

0.437

High

608187

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

608205

TRI33
E3 ubiquitin-protein ligase TRIM33

1

3

High-throughput

0.437

High

400242

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.426

High

608140

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

608159

RN169
E3 ubiquitin-protein ligase RNF169

1

0

Small-scale

0.426

High

608180

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.426

High

608206

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.426

High

608210

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

0

High-throughput

0.426

High

608105

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

608181

RM20
Large ribosomal subunit protein bL20m

1

0

High-throughput

0.279

Low

608178

H2A1J
Histone H2A type 1-J

1

0

High-throughput

0.269

Low

302142

NEBL
Nebulette

1

0

High-throughput

0.249

Low

608085

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.249

Low

608131

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

608139

ANR55
Ankyrin repeat domain-containing protein 55

1

0

High-throughput

0.249

Low

608156

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

608171

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.249

Low

608203

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

Small-scale

0.249

Low

608207

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

608211

INSI2
Insulin-induced gene 2 protein

1

0

High-throughput

0.249

Low

344087

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

608138

VACHT
Vesicular acetylcholine transporter

1

0

High-throughput

0.232

Low

608147

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low

608199

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025