HitPredict

Interactor 1: TFE2 (P15806)
Transcription factor E2-alpha (Immunoglobulin enhancer-binding factor E12/E47) (Transcription factor 3) (TCF-3) (Transcription factor A1)
Gene: Tcf3

Interactor 2: ID3 (P41133)
DNA-binding protein inhibitor ID-3 (ID-like protein inhibitor HLH 462) (Inhibitor of DNA binding 3) (Inhibitor of differentiation 3)
Gene: ID3

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	8759016, 22354994
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0010628 - positive regulation of gene expression GO:0043425 - bHLH transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 651 Mm			1 119
+	Rn
		600264 TFE2_RAT (1-651): 0: 899: 95.08		ID3_RAT (1-119): 2.56e-63: 189: 99.16
+	Hs
		551503 TFE2_HUMAN (2-651): 0: 854: 80.52		ID3_HUMAN (1-119): 9.85e-65: 193: 96.64
+	Mm
		550184 TFE2_MOUSE (1-651): 0: 901: 100.00		ID2_MOUSE (1-118): 4.51e-42: 136: 39.13
+	Mm
		550178 TFE2_MOUSE (1-651): 0: 901: 100.00		ID1_MOUSE (3-100): 7.62e-41: 134: 46.60
+	Mm
		550218 TFE2_MOUSE (1-651): 0: 901: 100.00		Q6GTZ3_MOUSE (3-100): 1e-39: 131: 46.60
+	Hs
		551478 TFE2_HUMAN (2-651): 0: 854: 80.52		ID1_HUMAN (1-100): 2.57e-43: 140: 47.22
+	Hs
		551502 TFE2_HUMAN (2-651): 0: 854: 80.52		ID2_HUMAN (1-118): 1.49e-42: 137: 39.86
+	Hs
		551480 TFE2_HUMAN (2-651): 0: 854: 80.52		ID4_HUMAN (1-88): 2.39e-27: 100: 38.94
+	Hs
		971137 HTF4_HUMAN (1-651): 0: 719: 48.71		ID3_HUMAN (1-119): 9.85e-65: 193: 96.64
+	Mm
		780945 HTF4_MOUSE (1-651): 0: 721: 46.95		ID3_MOUSE (1-119): 2.86e-63: 189: 100.00
+	Mm
		780944 ITF2_MOUSE (2-651): 0: 710: 48.13		ID3_MOUSE (1-119): 2.86e-63: 189: 100.00
+	Hs
		780982 HTF4_HUMAN (1-651): 0: 719: 48.71		ID1_HUMAN (1-100): 2.57e-43: 140: 47.22
+	Mm
		781007 HTF4_MOUSE (1-651): 0: 721: 46.95		ID2_MOUSE (1-118): 4.51e-42: 136: 39.13
+	Hs
		970599 HTF4_HUMAN (1-651): 0: 719: 48.71		ID2_HUMAN (1-118): 1.49e-42: 137: 39.86
+	Mm
		1142448 HTF4_MOUSE (1-651): 0: 721: 46.95		Q6GTZ3_MOUSE (3-100): 1e-39: 131: 46.60
+	Mm
		781006 ITF2_MOUSE (2-651): 0: 710: 48.13		ID2_MOUSE (1-118): 4.51e-42: 136: 39.13
+	Hs
		551084 ITF2_HUMAN (2-651): 0: 702: 47.83		ID1_HUMAN (1-100): 2.57e-43: 140: 47.22
+	Mm
		1141284 ITF2_MOUSE (2-651): 0: 710: 48.13		Q6GTZ3_MOUSE (3-100): 1e-39: 131: 46.60
+	Hs
		814913 HTF4_HUMAN (1-651): 0: 719: 48.71		ID4_HUMAN (1-88): 2.39e-27: 100: 38.94
+	Hs
		551089 ITF2_HUMAN (2-651): 0: 702: 47.83		ID4_HUMAN (1-88): 2.39e-27: 100: 38.94