HitPredict

Interactor 1: PCNA (P15873)
Proliferating cell nuclear antigen (PCNA)
Gene: POL30

Interactor 2: MSH2 (P25847)
DNA mismatch repair protein MSH2 (MutS protein homolog 2)
Gene: MSH2

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.741

Property	Details
Experiments	23869605, 11005803, 17720936, 8858149, 12435741, 17531814, 24981171
Identification Methods	pull down, two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000710 - meiotic mismatch repair GO:0005634 - nucleus GO:0006298 - mismatch repair GO:0030466 - silent mating-type cassette heterochromatin formation
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 258 Sc			1 964
+	Hs
		517121 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		MSH2_HUMAN (3-960): 0: 933: 39.25
+	Hs
		238260 RAD1_HUMAN (2-258): 1.09e-64: 204: 15.87		MSH2_HUMAN (3-960): 0: 933: 39.25
+	Hs
		517148 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		MSH6_HUMAN (13-913): 0: 758: 21.07
+	Sp
		251607 PCNA_SCHPO (1-258): 9.83e-103: 300: 44.57		MSH6_SCHPO (17-885): 0: 721: 22.22
+	Hs
		517045 PCNA_HUMAN (1-258): 2.37e-109: 317: 35.52		MSH3_HUMAN (17-941): 0: 661: 22.02
+	Hs
		238262 RAD1_HUMAN (2-258): 1.09e-64: 204: 15.87		MSH6_HUMAN (13-913): 0: 758: 21.07
+	Sc
		550570 PCNA_YEAST (1-258): 5.31e-95: 281: 100.00		MSH6_YEAST (17-884): 0: 628: 21.63
+	Hs
		238253 RAD1_HUMAN (2-258): 1.09e-64: 204: 15.87		MSH3_HUMAN (17-941): 0: 661: 22.02
+	Sc
		550518 PCNA_YEAST (1-258): 5.31e-95: 281: 100.00		MSH3_YEAST (4-890): 1.12e-167: 518: 21.14