Protein: CLK3
Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)

Gene: CLK3
Organism: Homo sapiens
Interactions: 214
UniProt ID: P49761

Gene Ontology (top 5):
GO:0001669 - acrosomal vesicle
GO:0003723 - RNA binding
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

833850

CLK2
Dual specificity protein kinase CLK2

8

17

High-throughput

0.975

High

834019

SRPK2
SRSF protein kinase 2

5

18

High-throughput

0.941

High

834037

TRA2A
Transformer-2 protein homolog alpha

5

19

High-throughput

0.932

High

834017

TRA2B
Transformer-2 protein homolog beta

5

20

High-throughput

0.931

High

834109

SRSF8
Serine/arginine-rich splicing factor 8

5

14

High-throughput

0.927

High

834084

SNIP1
Smad nuclear-interacting protein 1

5

2

High-throughput

0.926

High

834035

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

4

13

High-throughput

0.909

High

431656

HS90A
Heat shock protein HSP 90-alpha

4

20

High-throughput

0.903

High

266942

SRS10
Serine/arginine-rich splicing factor 10

4

20

High-throughput

0.902

High

834048

RNPS1
RNA-binding protein with serine-rich domain 1

4

15

High-throughput

0.902

High

834002

CLK3
Dual specificity protein kinase CLK3

4

17

High-throughput

0.896

High

834026

SRSF1
Serine/arginine-rich splicing factor 1

3

20

High-throughput

0.863

High

437997

HS90B
Heat shock protein HSP 90-beta

3

20

High-throughput

0.861

High

441957

RU17
U1 small nuclear ribonucleoprotein 70 kDa

3

17

High-throughput

0.861

High

834022

SRSF3
Serine/arginine-rich splicing factor 3

3

20

High-throughput

0.858

High

834051

CDC37
Hsp90 co-chaperone Cdc37

5

5

High-throughput

0.837

High

432605

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

2

20

High-throughput

0.811

High

641667

U2AF2
Splicing factor U2AF 65 kDa subunit

2

20

High-throughput

0.811

High

834030

ELAV2
ELAV-like protein 2

2

15

High-throughput

0.811

High

834045

ZN638
Zinc finger protein 638

2

11

High-throughput

0.811

High

834053

SRSF7
Serine/arginine-rich splicing factor 7

2

20

High-throughput

0.811

High

834087

SRS12
Serine/arginine-rich splicing factor 12

2

20

High-throughput

0.811

High

282577

RNF8
E3 ubiquitin-protein ligase RNF8

2

12

High-throughput

0.783

High

834052

U1SBP
U11/U12 small nuclear ribonucleoprotein 35 kDa protein

2

14

High-throughput

0.783

High

834086

ZN473
Zinc finger protein 473

2

2

High-throughput

0.783

High

834145

ZN777
Zinc finger protein 777

2

3

High-throughput

0.783

High

834149

ZN835
Zinc finger protein 835

2

1

High-throughput

0.783

High

834091

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

6

Small-scale

0.747

High

161798

ZN263
Zinc finger protein 263

1

3

High-throughput

0.740

High

483432

RBY1A
RNA-binding motif protein, Y chromosome, family 1 member A1

1

20

High-throughput

0.740

High

745097

RBMX
RNA-binding motif protein, X chromosome

1

20

High-throughput

0.740

High

834049

RBY1F
RNA-binding motif protein, Y chromosome, family 1 member F/J

1

20

High-throughput

0.740

High

834012

PSME3
Proteasome activator complex subunit 3

6

2

High-throughput

0.738

High

834113

RSRP1
Arginine/serine-rich protein 1

5

1

High-throughput

0.722

High

834014

1433G
14-3-3 protein gamma

5

20

High-throughput

0.714

High

834040

SCRIB
Protein scribble homolog

4

3

High-throughput

0.704

High

834142

GPTC8
G patch domain-containing protein 8

4

11

High-throughput

0.704

High

834148

SRRM2
Serine/arginine repetitive matrix protein 2

4

20

High-throughput

0.704

High

145976

SH2B2
SH2B adapter protein 2

2

14

High-throughput

0.700

High

834072

RBBP6
E3 ubiquitin-protein ligase RBBP6

4

10

High-throughput

0.699

High

71086

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

20

High-throughput

0.691

High

118706

AIP
AH receptor-interacting protein

1

10

High-throughput

0.691

High

236724

CCNT1
Cyclin-T1

1

20

High-throughput

0.691

High

241282

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

20

High-throughput

0.691

High

516417

PABP1
Polyadenylate-binding protein 1

1

10

High-throughput

0.691

High

834003

CDK9
Cyclin-dependent kinase 9

1

17

High-throughput

0.691

High

834016

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

4

High-throughput

0.691

High

834025

SRS11
Serine/arginine-rich splicing factor 11

1

9

High-throughput

0.691

High

834027

SRSF4
Serine/arginine-rich splicing factor 4

1

20

High-throughput

0.691

High

834031

SRSF5
Serine/arginine-rich splicing factor 5

1

20

High-throughput

0.691

High

834032

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.691

High

834033

PABP4
Polyadenylate-binding protein 4

1

11

High-throughput

0.691

High

834036

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

19

High-throughput

0.691

High

834039

SAFB2
Scaffold attachment factor B2

1

20

High-throughput

0.691

High

834043

RRP5
Protein RRP5 homolog

1

7

High-throughput

0.691

High

834056

LARP7
La-related protein 7

1

20

High-throughput

0.691

High

834096

PABP5
Polyadenylate-binding protein 5

1

12

High-throughput

0.691

High

834097

RMXL1
RNA binding motif protein, X-linked-like-1

1

20

High-throughput

0.691

High

834105

SRPK1
SRSF protein kinase 1

1

18

High-throughput

0.691

High

834106

RBM15
RNA-binding protein 15

1

20

High-throughput

0.691

High

834116

PDIP3
Polymerase delta-interacting protein 3

1

3

High-throughput

0.691

High

834134

SLTM
SAFB-like transcription modulator

1

20

High-throughput

0.691

High

834140

PUF60
Poly(U)-binding-splicing factor PUF60

1

20

High-throughput

0.691

High

132782

SDCB1
Syntenin-1

3

6

High-throughput

0.675

High

453054

HXB7
Homeobox protein Hox-B7

3

7

High-throughput

0.675

High

568017

HXB6
Homeobox protein Hox-B6

3

5

High-throughput

0.675

High

834066

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

3

5

High-throughput

0.675

High

834070

MEPCE
7SK snRNA methylphosphate capping enzyme

3

3

High-throughput

0.675

High

834117

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

3

6

High-throughput

0.675

High

834118

PIP30
PSME3-interacting protein

4

0

High-throughput

0.670

High

669552

OAS2
2'-5'-oligoadenylate synthase 2

4

0

High-throughput

0.668

High

834073

ZCH18
Zinc finger CCCH domain-containing protein 18

3

20

High-throughput

0.667

High

834121

PININ
Pinin

3

3

High-throughput

0.667

High

834152

LC7L2
Putative RNA-binding protein Luc7-like 2

3

6

High-throughput

0.667

High

834081

CLASR
CLK4-associating serine/arginine rich protein

3

9

High-throughput

0.665

High

834018

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.662

High

834156

TNPO3
Transportin-3

5

7

High-throughput

0.662

High

834112

LRRC1
Leucine-rich repeat-containing protein 1

4

4

High-throughput

0.643

High

834024

1433F
14-3-3 protein eta

4

20

High-throughput

0.636

High

131646

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

2

11

High-throughput

0.628

High

216472

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

2

7

High-throughput

0.628

High

834034

PPIG
Peptidyl-prolyl cis-trans isomerase G

2

6

High-throughput

0.628

High

834061

ZC3HD
Zinc finger CCCH domain-containing protein 13

2

20

High-throughput

0.628

High

834062

PR38B
Pre-mRNA-splicing factor 38B

2

10

High-throughput

0.628

High

834068

LARP1
La-related protein 1

2

16

High-throughput

0.628

High

834080

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

2

4

High-throughput

0.628

High

834083

PPHLN
Periphilin-1

2

2

High-throughput

0.628

High

834092

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

11

High-throughput

0.628

High

834098

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

11

High-throughput

0.628

High

834104

YTDC1
YTH domain-containing protein 1

2

6

High-throughput

0.628

High

834108

ANM1
Protein arginine N-methyltransferase 1

2

6

High-throughput

0.628

High

834130

TOPRS
E3 ubiquitin-protein ligase Topors

2

3

High-throughput

0.628

High

834136

BCLF1
Bcl-2-associated transcription factor 1

2

18

High-throughput

0.628

High

834143

ACINU
Apoptotic chromatin condensation inducer in the nucleus

2

17

High-throughput

0.628

High

834151

TR150
Thyroid hormone receptor-associated protein 3

2

20

High-throughput

0.628

High

834126

SLAF7
SLAM family member 7

1

2

High-throughput

0.625

High

202097

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

10

High-throughput

0.621

High

834011

CDC42
Cell division control protein 42 homolog

1

4

High-throughput

0.618

High

834013

RHOA
Transforming protein RhoA

1

4

High-throughput

0.618

High

834041

RBM39
RNA-binding protein 39

1

20

High-throughput

0.618

High

834128

ANLN
Anillin

1

2

High-throughput

0.618

High

834127

LUC7L
Putative RNA-binding protein Luc7-like 1

3

5

High-throughput

0.609

High

446894

HXC4
Homeobox protein Hox-C4

2

4

High-throughput

0.606

High

489850

ARRS
S-arrestin

2

1

High-throughput

0.606

High

834029

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

834060

NKAPL
NKAP-like protein

2

2

High-throughput

0.606

High

834078

CHERP
Calcium homeostasis endoplasmic reticulum protein

2

4

High-throughput

0.606

High

834137

NXF1
Nuclear RNA export factor 1

2

2

High-throughput

0.606

High

834044

LBR
Delta(14)-sterol reductase LBR

2

0

High-throughput

0.602

High

834064

VIR
Protein virilizer homolog

2

0

High-throughput

0.602

High

646728

1433T
14-3-3 protein theta

2

20

High-throughput

0.601

High

683207

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.601

High

834004

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

14

High-throughput

0.584

High

834057

H90B4
Putative heat shock protein HSP 90-beta 4

1

20

High-throughput

0.575

High

834058

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.575

High

834069

NKAP1
Uncharacterized protein NKAPD1

2

1

High-throughput

0.574

High

834102

SAHH3
Adenosylhomocysteinase 3

2

7

High-throughput

0.574

High

203643

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

2

High-throughput

0.573

High

369195

ESR1
Estrogen receptor

2

11

High-throughput

0.571

High

834085

LNX1
E3 ubiquitin-protein ligase LNX

2

8

High-throughput

0.553

High

834095

DDT4L
DNA damage-inducible transcript 4-like protein

2

1

High-throughput

0.553

High

834123

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.553

High

834111

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.543

High

127746

SAP18
Histone deacetylase complex subunit SAP18

1

3

High-throughput

0.536

High

172838

CASC3
Protein CASC3

1

6

High-throughput

0.536

High

181173

NUP42
Nucleoporin NUP42

1

1

High-throughput

0.536

High

238648

IMA7
Importin subunit alpha-7

1

9

High-throughput

0.536

High

256484

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

1

High-throughput

0.536

High

303021

HEXI1
Protein HEXIM1

1

4

High-throughput

0.536

High

304073

UBR5
E3 ubiquitin-protein ligase UBR5

1

14

High-throughput

0.536

High

321019

PTBP3
Polypyrimidine tract-binding protein 3

1

14

High-throughput

0.536

High

386316

P53
Cellular tumor antigen p53

1

6

High-throughput

0.536

High

627213

MCM3
DNA replication licensing factor MCM3

1

8

High-throughput

0.536

High

834006

IMA5
Importin subunit alpha-5

1

9

High-throughput

0.536

High

834009

RRP1
Ribosomal RNA processing protein 1 homolog A

1

2

High-throughput

0.536

High

834028

NCBP1
Nuclear cap-binding protein subunit 1

1

2

High-throughput

0.536

High

834042

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

6

High-throughput

0.536

High

834046

IMB1
Importin subunit beta-1

1

5

High-throughput

0.536

High

834054

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

15

High-throughput

0.536

High

834055

RN151
RING finger protein 151

1

17

High-throughput

0.536

High

834063

LAR1B
La-related protein 1B

1

14

High-throughput

0.536

High

834067

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

1

High-throughput

0.536

High

834074

CARM1
Histone-arginine methyltransferase CARM1

1

6

High-throughput

0.536

High

834075

SPAS2
Spermatogenesis-associated serine-rich protein 2

1

2

High-throughput

0.536

High

834076

ABC3F
DNA dC->dU-editing enzyme APOBEC-3F

1

4

High-throughput

0.536

High

834079

SRRM1
Serine/arginine repetitive matrix protein 1

1

20

High-throughput

0.536

High

834088

LAR4B
La-related protein 4B

1

14

High-throughput

0.536

High

834093

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

11

High-throughput

0.536

High

834101

CHMP6
Charged multivesicular body protein 6

1

5

High-throughput

0.536

High

834103

ZFR
Zinc finger RNA-binding protein

1

7

High-throughput

0.536

High

834115

SRRT
Serrate RNA effector molecule homolog

1

2

High-throughput

0.536

High

834119

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

4

High-throughput

0.536

High

834124

LN28A
Protein lin-28 homolog A

1

8

High-throughput

0.536

High

834132

SPS2L
SPATS2-like protein

1

2

High-throughput

0.536

High

834133

ARGL1
Arginine and glutamate-rich protein 1

1

2

High-throughput

0.536

High

834135

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.536

High

834138

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.536

High

834141

PURG
Purine-rich element-binding protein gamma

1

3

High-throughput

0.536

High

834144

ZN346
Zinc finger protein 346

1

1

High-throughput

0.536

High

834147

CHIP
E3 ubiquitin-protein ligase CHIP

1

7

High-throughput

0.536

High

834150

YBOX2
Y-box-binding protein 2

1

4

High-throughput

0.536

High

834155

CHTOP
Chromatin target of PRMT1 protein

1

2

High-throughput

0.536

High

834157

RT18B
Small ribosomal subunit protein mS40

1

1

High-throughput

0.536

High

834158

CFA20
Cilia- and flagella-associated protein 20

1

1

High-throughput

0.536

High

157717

GEMI2
Gem-associated protein 2

1

0

High-throughput

0.513

High

448575

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

834020

RT35
Small ribosomal subunit protein mS35

1

0

High-throughput

0.513

High

834089

RT31
Small ribosomal subunit protein mS31

1

0

High-throughput

0.513

High

834099

PTCD3
Small ribosomal subunit protein mS39

1

0

High-throughput

0.513

High

834100

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

834153

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.513

High

834154

CCDC9
Coiled-coil domain-containing protein 9

1

0

High-throughput

0.513

High

834159

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.513

High

153606

ANM5
Protein arginine N-methyltransferase 5

1

8

High-throughput

0.508

High

394341

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

808048

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

9

High-throughput

0.501

High

834120

MAGT1
Magnesium transporter protein 1

1

0

High-throughput

0.493

High

216052

NRDC
Nardilysin

1

1

High-throughput

0.489

High

834077

PLD3
5'-3' exonuclease PLD3

1

2

High-throughput

0.489

High

834082

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

2

High-throughput

0.489

High

834094

SH3K1
SH3 domain-containing kinase-binding protein 1

1

1

High-throughput

0.489

High

834122

E41L1
Band 4.1-like protein 1

1

7

High-throughput

0.489

High

834146

PAI2B
Polyadenylate-binding protein-interacting protein 2B

1

1

High-throughput

0.489

High

267955

EED
Polycomb protein EED

1

16

High-throughput

0.479

High

346238

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.479

High

650672

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

659910

ERCC5
DNA excision repair protein ERCC-5

1

11

High-throughput

0.479

High

683907

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

697725

TF2H1
General transcription factor IIH subunit 1

1

3

High-throughput

0.479

High

736319

RL4
Large ribosomal subunit protein uL4

1

2

High-throughput

0.479

High

834005

IMA1
Importin subunit alpha-1

1

9

High-throughput

0.479

High

834007

TERF1
Telomeric repeat-binding factor 1

1

11

High-throughput

0.479

High

834015

1433E
14-3-3 protein epsilon

1

8

High-throughput

0.479

High

834023

ENL
Protein ENL

1

14

High-throughput

0.479

High

834038

TF2H3
General transcription factor IIH subunit 3

1

2

High-throughput

0.479

High

834047

TNIP1
TNFAIP3-interacting protein 1

1

16

High-throughput

0.479

High

834050

TERF2
Telomeric repeat-binding factor 2

1

12

High-throughput

0.479

High

834059

Q59FZ7
DNA-repair protein complementing XP-G cells variant

1

11

High-throughput

0.479

High

834065

Q6ICH2
Apolipoprotein B mRNA editing enzyme catalytic subunit 3D

1

4

High-throughput

0.479

High

834071

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

834090

ESR2
Estrogen receptor beta

1

11

High-throughput

0.479

High

834114

HIRP3
HIRA-interacting protein 3

1

4

High-throughput

0.479

High

834125

RC3H2
Roquin-2

1

11

High-throughput

0.479

High

834131

RAD18
E3 ubiquitin-protein ligase RAD18

1

2

High-throughput

0.479

High

834139

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

834129

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.460

High

834107

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.458

High

70127

B2CML4
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3DE

1

4

High-throughput

0.445

High

834008

SUMO3
Small ubiquitin-related modifier 3

1

3

Small-scale

0.445

High

834010

KR103
Keratin-associated protein 10-3

1

8

High-throughput

0.439

High

100595

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

834110

ATGA1
Autophagy-related protein 101

1

2

High-throughput

0.437

High

834021

RT34
Small ribosomal subunit protein mS34

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024