HitPredict

Interactor 1: ITF2 (P15884)
Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)
Gene: TCF4

Interactor 2: RBTN1 (P25800)
Rhombotin-1 (Cysteine-rich protein TTG-1) (LIM domain only protein 1) (LMO-1) (T-cell translocation protein 1)
Gene: LMO1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	25416956
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~LIM
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 667 Hs			1 156
+	Mm
		638617 ITF2_MOUSE (1-667): 0: 918: 96.87		RBTN2_MOUSE (7-149): 2.92e-46: 149: 54.17
+	Hs
		551107 ITF2_HUMAN (1-667): 0: 908: 100.00		LMO4_HUMAN (7-154): 3.11e-39: 132: 47.30
+	Hs
		551210 ITF2_HUMAN (1-667): 0: 908: 100.00		LMO3_HUMAN (13-156): 1.16e-38: 130: 89.58
+	Hs
		551233 ITF2_HUMAN (1-667): 0: 908: 100.00		LHX4_HUMAN (4-79): 1.31e-14: 71.5: 19.48
+	Mm
		550181 TFE2_MOUSE (1-667): 0: 702: 47.69		RBTN2_MOUSE (7-149): 2.92e-46: 149: 54.17
+	Hs
		551558 TFE2_HUMAN (1-667): 0: 733: 49.71		LMX1A_HUMAN (83-152): 5.44e-09: 55.3: 19.72