HitPredict

Interactor 1: ITF2 (P15884)
Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)
Gene: TCF4

Interactor 2: LMO4 (P61968)
LIM domain transcription factor LMO4 (Breast tumor autoantigen) (LIM domain only protein 4) (LMO-4)
Gene: LMO4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	25416956, 32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid prey pooling approach, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~LIM
Common GO terms	GO:0005667 - transcription regulator complex GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 667 Hs			1 165
+	Mm
		638617 ITF2_MOUSE (1-667): 0: 918: 96.87		RBTN2_MOUSE (23-148): 3.99e-46: 149: 45.67
+	Hs
		551210 ITF2_HUMAN (1-667): 0: 908: 100.00		LMO3_HUMAN (13-152): 4.29e-41: 136: 47.86
+	Hs
		551072 ITF2_HUMAN (1-667): 0: 908: 100.00		RBTN1_HUMAN (1-143): 1.92e-36: 125: 48.25
+	Hs
		551233 ITF2_HUMAN (1-667): 0: 908: 100.00		LHX4_HUMAN (82-165): 1.58e-12: 65.8: 18.75
+	Mm
		550181 TFE2_MOUSE (1-667): 0: 702: 47.69		RBTN2_MOUSE (23-148): 3.99e-46: 149: 45.67
+	Hs
		551558 TFE2_HUMAN (1-667): 0: 733: 49.71		LMX1A_HUMAN (15-82): 3.12e-10: 59.3: 30.44