Protein: RN125
E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1)

Gene: RN125, RNF125
Organism: Homo sapiens
Interactions: 55
UniProt ID: Q96EQ8

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000209 - protein polyubiquitination
GO:0002039 - p53 binding
GO:0002250 - adaptive immune response
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

906742

UB2D1
Ubiquitin-conjugating enzyme E2 D1

6

20

Small-scale

0.941

High

957162

UB2D3
Ubiquitin-conjugating enzyme E2 D3

4

20

Small-scale

0.891

High

168557

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

3

20

Small-scale

0.876

High

982281

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

20

Small-scale

0.871

High

1389536

RN125
E3 ubiquitin-protein ligase RNF125

3

19

Small-scale

0.840

High

996002

UB2L3
Ubiquitin-conjugating enzyme E2 L3

2

20

High-throughput

0.791

High

957645

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

20

High-throughput

0.768

High

1389538

UB2E2
Ubiquitin-conjugating enzyme E2 E2

2

20

Small-scale

0.726

High

345103

RIGI
Antiviral innate immune response receptor RIG-I

4

20

Small-scale

0.704

High

957814

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

High-throughput

0.698

High

1218742

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.698

High

1383919

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1389442

CHFR
E3 ubiquitin-protein ligase CHFR

1

16

High-throughput

0.698

High

1389542

PCGF1
Polycomb group RING finger protein 1

1

19

High-throughput

0.698

High

1389548

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

508425

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

Small-scale

0.696

High

1389544

IFIH1
Interferon-induced helicase C domain-containing protein 1

2

20

Small-scale

0.634

High

1389547

PD1L1
Programmed cell death 1 ligand 1

2

10

Small-scale

0.584

High

414391

P53
Cellular tumor antigen p53

1

10

Small-scale

0.561

High

1121302

TRI14
Tripartite motif-containing protein 14

1

18

Small-scale

0.561

High

714345

PML
Protein PML

1

20

High-throughput

0.541

High

1278499

TRI46
Tripartite motif-containing protein 46

1

20

High-throughput

0.541

High

141612

DDX3X
ATP-dependent RNA helicase DDX3X

2

11

Small-scale

0.533

High

658752

JAK1
Tyrosine-protein kinase JAK1

2

20

Small-scale

0.533

High

75522

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

1278068

MAVS
Mitochondrial antiviral-signaling protein

1

19

Small-scale

0.528

High

1389537

ZN414
Zinc finger protein 414

1

1

High-throughput

0.481

High

363701

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

623482

RO52
E3 ubiquitin-protein ligase TRIM21

1

18

Small-scale

0.479

High

1124685

SRC8
Src substrate cortactin

1

13

Small-scale

0.479

High

1389539

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

17

Small-scale

0.479

High

288489

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

20

High-throughput

0.439

High

1207383

EFHC1
EF-hand domain-containing protein 1

1

2

High-throughput

0.439

High

1274013

BHA09
Class A basic helix-loop-helix protein 9

1

4

High-throughput

0.439

High

1350967

MYOZ3
Myozenin-3

1

1

High-throughput

0.439

High

1389543

FND11
Fibronectin type III domain-containing protein 11

1

1

High-throughput

0.439

High

289653

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

16

Small-scale

0.437

High

481358

HMGB1
High mobility group protein B1

1

16

Small-scale

0.437

High

551196

PCNA
Proliferating cell nuclear antigen

1

6

Small-scale

0.437

High

568835

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

8

Small-scale

0.437

High

772954

MYH9
Myosin-9

1

9

Small-scale

0.437

High

895633

SERPH
Serpin H1

1

9

Small-scale

0.437

High

912593

GDIR1
Rho GDP-dissociation inhibitor 1

1

2

Small-scale

0.437

High

953029

ACTB
Actin, cytoplasmic 1

1

18

Small-scale

0.437

High

1009804

IN35
Interferon-induced 35 kDa protein

1

4

Small-scale

0.437

High

1062589

DHX9
ATP-dependent RNA helicase A

1

10

Small-scale

0.437

High

1065356

SSRP1
FACT complex subunit SSRP1

1

14

Small-scale

0.437

High

1100955

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

Small-scale

0.437

High

1270765

DDX46
Probable ATP-dependent RNA helicase DDX46

1

12

Small-scale

0.437

High

1369346

DDX17
Probable ATP-dependent RNA helicase DDX17

1

12

Small-scale

0.437

High

1389540

SPB12
Serpin B12

1

7

Small-scale

0.437

High

1389545

ILRL2
Interleukin-1 receptor-like 2

1

13

Small-scale

0.437

High

1389546

DDX21
Nucleolar RNA helicase 2

1

19

Small-scale

0.437

High

1389541

SPAG8
Sperm-associated antigen 8

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025