HitPredict

Interactor 1: ITF2 (P15884)
Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)
Gene: TCF4

Interactor 2: TCF24 (Q7RTU0)
Transcription factor 24 (TCF-24)
Gene: TCF24

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.926

Property	Details
Experiments	25609649, 28514442, 32296183, 33961781, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 667 Hs			1 167
+	Mm
		623784 ITF2_MOUSE (1-667): 0: 918: 96.87		MYF5_MOUSE (14-157): 2.42e-32: 117: 16.13
+	Mm
		644472 ITF2_MOUSE (1-667): 0: 918: 96.87		TWST1_MOUSE (2-137): 2.55e-32: 116: 25.74
+	Hs
		551186 ITF2_HUMAN (1-667): 0: 908: 100.00		TCF23_HUMAN (25-146): 6.8e-33: 117: 59.35
+	Mm
		1141281 ITF2_MOUSE (1-667): 0: 918: 96.87		HAND2_MOUSE (4-119): 1.84e-28: 106: 33.06
+	Hs
		551151 ITF2_HUMAN (1-667): 0: 908: 100.00		TWST1_HUMAN (7-137): 2.31e-31: 113: 26.72
+	Hs
		210856 ITF2_HUMAN (1-667): 0: 908: 100.00		TCF21_HUMAN (9-155): 1.18e-30: 111: 34.46
+	Hs
		551069 ITF2_HUMAN (1-667): 0: 908: 100.00		MYF6_HUMAN (2-139): 7.36e-30: 110: 19.57
+	Hs
		551184 ITF2_HUMAN (1-667): 0: 908: 100.00		PTF1A_HUMAN (4-108): 4.18e-29: 110: 29.06
+	Hs
		551122 ITF2_HUMAN (1-667): 0: 908: 100.00		HEN2_HUMAN (2-105): 2.95e-30: 108: 29.69
+	Hs
		524531 ITF2_HUMAN (1-667): 0: 908: 100.00		LYL1_HUMAN (5-130): 1.03e-27: 106: 32.28
+	Hs
		551106 ITF2_HUMAN (1-667): 0: 908: 100.00		HAND2_HUMAN (4-119): 1.84e-28: 106: 33.06
+	Hs
		551140 ITF2_HUMAN (1-667): 0: 908: 100.00		NDF1_HUMAN (42-128): 7.04e-27: 105: 26.44
+	Hs
		551200 ITF2_HUMAN (1-667): 0: 908: 100.00		ATOH7_HUMAN (1-140): 1.45e-28: 104: 31.51
+	Hs
		238584 ITF2_HUMAN (1-667): 0: 908: 100.00		MUSC_HUMAN (14-155): 3.37e-27: 102: 33.57
+	Hs
		330419 ITF2_HUMAN (1-667): 0: 908: 100.00		HAND1_HUMAN (26-119): 9.56e-26: 99.5: 40.43
+	Hs
		551155 ITF2_HUMAN (1-667): 0: 908: 100.00		TAL2_HUMAN (48-109): 4.78e-26: 97.2: 37.10
+	Hs
		551121 ITF2_HUMAN (1-667): 0: 908: 100.00		HEN1_HUMAN (51-105): 1.41e-25: 96.8: 49.09
+	Mm
		603981 ITF2_MOUSE (1-667): 0: 918: 96.87		TAL1_MOUSE (55-118): 5.42e-11: 61.4: 40.63
+	Hs
		551135 ITF2_HUMAN (1-667): 0: 908: 100.00		TCF15_HUMAN (50-105): 2.85e-14: 69.1: 44.64
+	Hs
		551187 ITF2_HUMAN (1-667): 0: 908: 100.00		SCX_HUMAN (50-105): 3.18e-13: 66.4: 41.07