HitPredict

Interactor 1: RFA2 (P15927)
Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)
Gene: RPA2

Interactor 2: ATM (Q13315)
Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated) (A-T mutated)
Gene: ATM

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	22977173, 10713094, 9725899
Identification Methods	enzymatic study, affinity chromatography technology, coimmunoprecipitation, in-gel kinase assay
Interaction Type	direct interaction, physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000723 - telomere maintenance GO:0000724 - double-strand break repair via homologous recombination GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035861 - site of double-strand break
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 270 Hs			1 3056
+	Hs
		552661 RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00		ATR_HUMAN (1223-3056): 0: 1214: 20.34
+	Hs
		552139 RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00		MTOR_HUMAN (1846-3055): 0: 843: 16.65
+	Hs
		787469 RFA4_HUMAN (1-268): 6.87e-96: 283: 45.56		MTOR_HUMAN (1846-3055): 0: 843: 16.65
+	Hs
		554140 RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00		TRRAP_HUMAN (1874-3056): 0: 683: 12.97
+	Sc
		644752 RFA2_YEAST (4-264): 9.48e-71: 220: 25.61		ATR_YEAST (1461-3055): 0: 789: 17.49
+	Hs
		1026601 RFA4_HUMAN (1-268): 6.87e-96: 283: 45.56		TRRAP_HUMAN (1874-3056): 0: 683: 12.97
+	Hs
		552483 RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00		PRKDC_HUMAN (2005-3056): 6.86e-155: 545: 17.20
+	Sc
		644751 RFA2_YEAST (4-264): 9.48e-71: 220: 25.61		ATM_YEAST (1782-3055): 0: 630: 22.42
+	Hs
		553480 RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00		SMG1_HUMAN (2626-2961): 7.72e-90: 331: 29.12