Protein: IMDH1
Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I)

Gene: IMDH1, IMPDH1
Organism: Homo sapiens
Interactions: 150
UniProt ID: P20839

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0003676 - nucleic acid binding
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0003938 - IMP dehydrogenase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

552499

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

7

16

High-throughput

0.961

High

635292

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

3

16

Small-scale

0.840

High

635358

ANKR9
Ankyrin repeat domain-containing protein 9

4

1

Small-scale

0.691

High

635313

SKP2
S-phase kinase-associated protein 2

3

2

High-throughput

0.662

High

635342

KLD8B
Kelch domain-containing protein 8B

3

1

High-throughput

0.662

High

635343

PUSL1
tRNA pseudouridine synthase-like 1

3

2

High-throughput

0.662

High

635353

SMCR8
Guanine nucleotide exchange protein SMCR8

3

1

High-throughput

0.662

High

635380

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

3

1

High-throughput

0.662

High

635382

TRIM6
Tripartite motif-containing protein 6

3

1

High-throughput

0.662

High

635386

WDR76
WD repeat-containing protein 76

3

4

High-throughput

0.662

High

635301

WHR1
Winged helix repair factor 1

3

0

High-throughput

0.634

High

635327

CAF17
Iron-sulfur cluster assembly factor IBA57, mitochondrial

3

0

High-throughput

0.634

High

635330

QTGAL
Queuosine-tRNA galactosyltransferase

3

0

High-throughput

0.634

High

635360

MTMR8
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR8

3

0

High-throughput

0.634

High

635388

ABCBA
ATP-binding cassette sub-family B member 10, mitochondrial

3

0

High-throughput

0.634

High

141904

PODXL
Podocalyxin

2

2

High-throughput

0.628

High

635294

GATA2
Endothelial transcription factor GATA-2

2

2

High-throughput

0.628

High

635314

PEX6
Peroxisomal ATPase PEX6

2

1

High-throughput

0.628

High

635370

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

2

2

High-throughput

0.628

High

635376

MET22
Methyltransferase-like protein 22

2

1

High-throughput

0.628

High

635401

MOK
MAPK/MAK/MRK overlapping kinase

2

3

High-throughput

0.628

High

635408

MTCH2
Mitochondrial carrier homolog 2

2

3

High-throughput

0.628

High

297752

PIAS2
E3 SUMO-protein ligase PIAS2

2

1

High-throughput

0.606

High

635308

RNF4
E3 ubiquitin-protein ligase RNF4

2

1

High-throughput

0.606

High

635324

ZRAB3
DNA annealing helicase and endonuclease ZRANB3

3

1

High-throughput

0.604

High

635328

WDR25
WD repeat-containing protein 25

3

1

High-throughput

0.604

High

635346

ARG39
Rho guanine nucleotide exchange factor 39

3

2

High-throughput

0.604

High

635355

DCAKD
Dephospho-CoA kinase domain-containing protein

3

2

High-throughput

0.604

High

635395

MTCH1
Mitochondrial carrier homolog 1

3

3

High-throughput

0.604

High

244809

TYW4
tRNA wybutosine-synthesizing protein 4

2

0

High-throughput

0.602

High

635311

ABD18
Protein ABHD18

2

0

High-throughput

0.602

High

635332

LRC8E
Volume-regulated anion channel subunit LRRC8E

2

0

High-throughput

0.602

High

635339

ATG4D
Cysteine protease ATG4D

2

0

High-throughput

0.602

High

635362

F120B
Constitutive coactivator of peroxisome proliferator-activated receptor gamma

2

0

High-throughput

0.602

High

635369

C560
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

2

0

High-throughput

0.602

High

635372

SOST
Sclerostin

2

0

High-throughput

0.602

High

635317

HLTF
Helicase-like transcription factor

2

5

High-throughput

0.601

High

635381

S2539
Mitochondrial glutathione transporter SLC25A39

2

5

High-throughput

0.601

High

329045

KLHL2
Kelch-like protein 2

2

0

High-throughput

0.585

High

635359

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.580

High

635406

ARIP4
Helicase ARIP4

2

0

High-throughput

0.580

High

333555

NDUC2
NADH dehydrogenase [ubiquinone] 1 subunit C2

2

0

High-throughput

0.576

High

635312

DYH14
Dynein axonemal heavy chain 14

2

0

High-throughput

0.576

High

635348

ENDOV
Endonuclease V

2

0

High-throughput

0.576

High

635323

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

2

3

High-throughput

0.574

High

635365

S2544
Solute carrier family 25 member 44

2

3

High-throughput

0.574

High

635399

MRM2
rRNA methyltransferase 2, mitochondrial

2

1

High-throughput

0.574

High

635402

BCS1
Mitochondrial chaperone BCS1

2

2

High-throughput

0.574

High

395484

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

635396

PD1L1
Programmed cell death 1 ligand 1

1

1

Small-scale

0.553

High

635322

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

2

1

High-throughput

0.549

High

635383

S2532
Solute carrier family 25 member 32

2

1

High-throughput

0.549

High

123583

MYO1C
Unconventional myosin-Ic

1

2

High-throughput

0.536

High

174927

SC16A
Protein transport protein Sec16A

1

2

High-throughput

0.536

High

219919

XRCC3
DNA repair protein XRCC3

1

1

High-throughput

0.536

High

486952

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.536

High

604770

HXB8
Homeobox protein Hox-B8

1

1

High-throughput

0.536

High

635304

LIMK1
LIM domain kinase 1

1

3

High-throughput

0.536

High

635305

DLX1
Homeobox protein DLX-1

1

3

High-throughput

0.536

High

635316

BOP1
Ribosome biogenesis protein BOP1

1

1

High-throughput

0.536

High

635318

EMC2
ER membrane protein complex subunit 2

1

4

High-throughput

0.536

High

635326

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

1

1

High-throughput

0.536

High

635350

ARRD2
Arrestin domain-containing protein 2

1

2

High-throughput

0.536

High

635391

SETD4
SET domain-containing protein 4

1

1

High-throughput

0.536

High

284279

GEMI
Geminin

1

0

High-throughput

0.518

High

275245

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.513

High

287438

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.513

High

635295

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

0

High-throughput

0.513

High

635299

KC1D
Casein kinase I isoform delta

1

0

High-throughput

0.513

High

635309

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.513

High

635315

RUNX2
Runt-related transcription factor 2

1

0

High-throughput

0.513

High

635333

ZN704
Zinc finger protein 704

1

0

High-throughput

0.513

High

635344

GTPB8
GTP-binding protein 8

1

0

High-throughput

0.513

High

635363

HBAP1
HSPB1-associated protein 1

1

0

High-throughput

0.513

High

635371

KLDC3
Kelch domain-containing protein 3

1

0

High-throughput

0.513

High

185423

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.501

High

635298

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

High-throughput

0.493

High

635347

EMC5
ER membrane protein complex subunit 5

1

1

High-throughput

0.489

High

635351

S2540
Mitochondrial glutathione transporter SLC25A40

1

2

High-throughput

0.489

High

635378

SCRT1
Transcriptional repressor scratch 1

1

1

High-throughput

0.489

High

635392

DJC11
DnaJ homolog subfamily C member 11

1

2

High-throughput

0.489

High

635307

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

176023

KDM6B
Lysine-specific demethylase 6B

1

2

Small-scale

0.479

High

240737

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

376704

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

1

High-throughput

0.479

High

400271

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

484816

HXB7
Homeobox protein Hox-B7

1

2

High-throughput

0.479

High

606214

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

635297

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

635303

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.479

High

635334

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

635384

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

635385

DUS21
Dual specificity protein phosphatase 21

1

2

High-throughput

0.479

High

635397

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

635400

VAX2
Ventral anterior homeobox 2

1

2

High-throughput

0.479

High

635407

MAFB
Transcription factor MafB

1

1

High-throughput

0.479

High

635336

Q7KZS0
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.470

High

635356

HTRA1
Serine protease HTRA1

1

0

High-throughput

0.460

High

635300

FAS
Fatty acid synthase

1

0

High-throughput

0.458

High

635310

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

635349

TXND5
Thioredoxin domain-containing protein 5

1

0

High-throughput

0.458

High

635379

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

Small-scale

0.458

High

635398

DPOLL
DNA polymerase lambda

1

0

High-throughput

0.458

High

326656

DUS14
Dual specificity protein phosphatase 14

1

2

High-throughput

0.445

High

635293

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

1

High-throughput

0.445

High

635296

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.445

High

635329

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.445

High

635331

ABLM2
Actin-binding LIM protein 2

1

2

High-throughput

0.445

High

635341

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

2

High-throughput

0.445

High

635361

FBX17
F-box only protein 17

1

1

High-throughput

0.445

High

635364

AURKB
Aurora kinase B

1

3

High-throughput

0.445

High

635393

FXL12
F-box/LRR-repeat protein 12

1

2

High-throughput

0.445

High

635394

SMAL1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

1

1

High-throughput

0.445

High

411340

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

635405

NR2E1
Nuclear receptor subfamily 2 group E member 1

1

3

High-throughput

0.437

High

635338

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

0

High-throughput

0.426

High

635345

GLT16
Polypeptide N-acetylgalactosaminyltransferase 16

1

0

High-throughput

0.426

High

635357

NXPE3
NXPE family member 3

1

0

High-throughput

0.426

High

635368

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

635373

TIRR
Tudor-interacting repair regulator protein

1

0

High-throughput

0.426

High

635374

SEN34
tRNA-splicing endonuclease subunit Sen34

1

0

High-throughput

0.426

High

635387

WDR54
WD repeat-containing protein 54

1

0

High-throughput

0.426

High

635389

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.426

High

635403

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

635404

NAGA
N-acetylglucosamine-6-phosphate deacetylase

1

0

High-throughput

0.426

High

94301

D6R9G5
Kelch like family member 2

1

1

High-throughput

0.407

High

635337

MAVS
Mitochondrial antiviral-signaling protein

1

4

High-throughput

0.407

High

635352

CF251
Cilia- and flagella-associated protein 251

1

1

High-throughput

0.407

High

635354

DCAF4
DDB1- and CUL4-associated factor 4

3

0

High-throughput

0.345

High

332201

UCP5
Brain mitochondrial carrier protein 1

2

0

High-throughput

0.328

High

635367

GUCD1
Protein GUCD1

2

0

High-throughput

0.328

High

188567

BCAT2
Branched-chain-amino-acid aminotransferase, mitochondrial

2

0

High-throughput

0.313

High

635375

TMM70
Transmembrane protein 70, mitochondrial

2

0

High-throughput

0.313

High

166860

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.279

Low

602193

TMM11
Transmembrane protein 11, mitochondrial

1

0

High-throughput

0.279

Low

635302

NAR1
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

1

0

High-throughput

0.279

Low

635306

C1QT8
Complement C1q tumor necrosis factor-related protein 8

1

0

High-throughput

0.279

Low

635320

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.279

Low

635366

SFXN2
Sideroflexin-2

1

0

High-throughput

0.279

Low

635390

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

0

High-throughput

0.279

Low

105319

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

352620

TCL1B
T-cell leukemia/lymphoma protein 1B

1

0

High-throughput

0.249

Low

635325

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

0

High-throughput

0.249

Low

635340

CQ082
Putative uncharacterized protein LINC02875

1

0

High-throughput

0.249

Low

223601

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

1

0

High-throughput

0.232

Low

635319

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

1

0

High-throughput

0.232

Low

635321

PGPS1
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

1

0

High-throughput

0.232

Low

635335

SH2D5
SH2 domain-containing protein 5

1

0

High-throughput

0.232

Low

635377

SIA7E
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025