HitPredict

Interactor 1: MUC1 (P15941)
Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]
Gene: MUC1

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28785086
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 746
+	Hs
		848225 HCFC1_HUMAN (7-1107): 6.45e-29: 128: 11.01		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1080263 MUC4_HUMAN (296-1142): 2.14e-16: 87.5: 10.86		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1080261 MINT_HUMAN (22-1062): 3.99e-14: 80.1: 9.50		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		146230 ARI1A_HUMAN (9-962): 3.38e-11: 70.2: 10.06		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1080127 KMT2C_HUMAN (3-610): 1.39e-10: 68.3: 12.67		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		331812 MDC1_HUMAN (3-737): 1.48e-23: 110: 11.44		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		1056940 MDC1_HUMAN (3-737): 1.48e-23: 110: 11.44		NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82
+	Hs
		1056971 MDC1_HUMAN (3-737): 1.48e-23: 110: 11.44		SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64
+	Hs
		203601 MAGC1_HUMAN (426-1076): 2.41e-11: 70.5: 7.99		SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90
+	Hs
		203726 Q86V38_HUMAN (457-1150): 1.22e-09: 65.2: 10.09		SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90
+	Hs
		848199 HCFC1_HUMAN (7-1107): 6.45e-29: 128: 11.01		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		848319 HCFC1_HUMAN (7-1107): 6.45e-29: 128: 11.01		SET1B_HUMAN (619-732): 1.38e-18: 93.2: 40.52
+	Hs
		165649 HCFC1_HUMAN (7-1107): 6.45e-29: 128: 11.01		SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71
+	Dm
		1129083 Q9VLS7_DROME (4-946): 1.2e-18: 94.7: 11.85		SET1_DROME (611-732): 1.27e-18: 93.2: 38.71
+	Dm
		54311 A1Z9J3_DROME (31-566): 5.35e-17: 89.5: 14.02		SET1_DROME (611-732): 1.27e-18: 93.2: 38.71
+	Hs
		975251 NCOA6_HUMAN (10-1050): 3.47e-16: 86.7: 9.70		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		1057804 NCOA6_HUMAN (10-1050): 3.47e-16: 86.7: 9.70		SET1B_HUMAN (619-732): 1.38e-18: 93.2: 40.52
+	Hs
		975285 KMT2C_HUMAN (3-610): 1.39e-10: 68.3: 12.67		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		1243853 KMT2C_HUMAN (3-610): 1.39e-10: 68.3: 12.67		SET1B_HUMAN (619-732): 1.38e-18: 93.2: 40.52
+	Hs
		165699 KMT2C_HUMAN (3-610): 1.39e-10: 68.3: 12.67		SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71