Protein: HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 (HMG-CoA reductase 2) (EC 1.1.1.34)

Gene: HMDH2, HMG2
Organism: Saccharomyces cerevisiae S288C
Interactions: 84
UniProt ID: P12684

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0004420 - hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005635 - nuclear envelope
GO:0005778 - peroxisomal membrane
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

554425

NSG1
Protein NSG1

4

1

Small-scale

0.898

High

554300

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

4

2

High-throughput

0.882

High

554388

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

2

2

High-throughput

0.785

High

554452

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

6

4

Small-scale

0.739

High

554402

CDC48
Cell division control protein 48

4

1

Small-scale

0.686

High

554442

UBC7
Ubiquitin-conjugating enzyme E2 7

3

0

Small-scale

0.625

High

554409

PRS7
26S proteasome regulatory subunit 7 homolog

2

3

Small-scale

0.571

High

554457

DFM1
DER1-like family member protein 1

2

0

Small-scale

0.559

High

554449

HRD3
ERAD-associated E3 ubiquitin-protein ligase component HRD3

1

1

Small-scale

0.536

High

554446

UBX2
UBX domain-containing protein 2

1

0

Small-scale

0.513

High

438598

SC160
Protein SCP160

1

1

High-throughput

0.479

High

554396

ACO1
Acyl-CoA desaturase 1

1

1

High-throughput

0.479

High

554397

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

554398

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

2

High-throughput

0.479

High

554400

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

554401

CWH43
Protein CWH43

1

1

High-throughput

0.479

High

554407

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

5

High-throughput

0.479

High

554410

SEC66
Translocation protein SEC66

1

1

High-throughput

0.479

High

554412

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

1

High-throughput

0.479

High

554413

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

5

High-throughput

0.479

High

554416

YET1
Endoplasmic reticulum transmembrane protein 1

1

3

High-throughput

0.479

High

554418

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

1

High-throughput

0.479

High

554420

NU170
Nucleoporin NUP170

1

1

High-throughput

0.479

High

554423

PHO88
SRP-independent targeting protein 3

1

1

High-throughput

0.479

High

554426

PO152
Nucleoporin POM152

1

1

High-throughput

0.479

High

554428

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

1

High-throughput

0.479

High

554430

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

1

High-throughput

0.479

High

554431

ELO3
Fatty acid elongase 3

1

1

High-throughput

0.479

High

554435

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

1

High-throughput

0.479

High

554436

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

5

High-throughput

0.479

High

554438

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.479

High

554441

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

1

High-throughput

0.479

High

554443

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

1

1

High-throughput

0.479

High

554448

ERP1
Protein ERP1

1

1

High-throughput

0.479

High

554451

YET3
Endoplasmic reticulum transmembrane protein 3

1

3

High-throughput

0.479

High

554458

PGA3
Plasma membrane-associated coenzyme Q6 reductase PGA3

1

1

High-throughput

0.479

High

554424

LAG1
Ceramide synthase LAG1

1

0

High-throughput

0.458

High

554447

RTN1
Reticulon-like protein 1

1

0

Small-scale

0.458

High

554454

GET3
ATPase GET3

1

0

Small-scale

0.458

High

485996

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.445

High

531577

RL4A
Large ribosomal subunit protein uL4A

1

1

Small-scale

0.437

High

554399

MAS5
Mitochondrial protein import protein MAS5

1

1

Small-scale

0.437

High

554405

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.437

High

554415

YKK0
Probable intramembrane protease YKL100C

1

1

High-throughput

0.437

High

554439

RL4B
Large ribosomal subunit protein uL4B

1

1

Small-scale

0.437

High

554445

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.437

High

554453

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.437

High

554455

YRA1
RNA annealing protein YRA1

1

1

Small-scale

0.437

High

358101

ADH1
Alcohol dehydrogenase 1

1

1

High-throughput

0.407

High

394166

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.407

High

525765

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.407

High

543621

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.407

High

554392

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.407

High

554393

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.407

High

554394

EF3A
Elongation factor 3A

1

1

High-throughput

0.407

High

554406

XPO1
Exportin-1

1

1

High-throughput

0.407

High

554422

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.407

High

554427

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

1

1

High-throughput

0.407

High

554429

IMB4
Importin subunit beta-4

1

1

High-throughput

0.407

High

554432

YTA12
Mitochondrial inner membrane m-AAA protease component YTA12

1

2

High-throughput

0.407

High

554434

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

554440

UFD1
Ubiquitin fusion degradation protein 1

2

0

Small-scale

0.318

High

554444

UME1
Transcriptional regulatory protein UME1

1

0

High-throughput

0.282

High

554456

SKM1
Serine/threonine-protein kinase SKM1

1

0

High-throughput

0.279

Low

554450

PIN3
[PSI+] inducibility protein 3

1

0

High-throughput

0.265

Low

554395

PHO85
Cyclin-dependent protein kinase PHO85

1

0

High-throughput

0.261

Low

433961

RL33A
Large ribosomal subunit protein eL33A

1

0

Small-scale

0.249

Low

434129

RL36A
Large ribosomal subunit protein eL36A

1

0

Small-scale

0.249

Low

554390

RL30
Large ribosomal subunit protein eL30

1

0

Small-scale

0.249

Low

554391

AMPL
Vacuolar aminopeptidase 1

1

0

Small-scale

0.249

Low

554411

NPL4
Nuclear protein localization protein 4

1

0

Small-scale

0.249

Low

554414

UBX1
UBX domain-containing protein 1

1

0

Small-scale

0.249

Low

554419

RL32
Large ribosomal subunit protein eL32

1

0

Small-scale

0.249

Low

554421

ATG8
Autophagy-related protein 8

1

0

Small-scale

0.249

Low

554437

RL17B
Large ribosomal subunit protein uL22B

1

0

Small-scale

0.249

Low

403326

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.232

Low

439213

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.232

Low

554389

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.232

Low

554403

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.232

Low

554404

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.232

Low

554408

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.232

Low

554417

EF1G2
Elongation factor 1-gamma 2

1

0

High-throughput

0.232

Low

554433

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025