HitPredict

Interactor 1: DCR2 (A1ZAW0)
Endoribonuclease Dcr-2 (Protein Dicer-2) (EC 3.1.26.3)
Gene: Dcr-2

Interactor 2: AGO2 (Q9VUQ5)
Protein argonaute-2
Gene: AGO2

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.853

The method score is based on:

Property Details
Experiments 22056986, 14512631, 20639883
Identification Methods affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains ArgoL1~PAZ, ArgoL2~PAZ, PAZ~PAZ, PAZ~Piwi, PAZ~Ribonuclease_3
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0009047 - dosage compensation by hyperactivation of X chromosome
GO:0016442 - RISC complex
GO:0030422 - siRNA processing
and 8 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1722
Dm

1 1214
+ Ce
+ Ce
+ Hs
+ Ce
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Dm
+ Ce
+ Ce
+ Ce
+ Dm
+ Dm
+ Dm
+ Dr
+ Dm
+ Ce
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024