Protein: POLO
Serine/threonine-protein kinase polo (EC 2.7.11.21)

Gene: POLO
Organism: Drosophila melanogaster
Interactions: 117
UniProt ID: P52304

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000776 - kinetochore
GO:0000915 - actomyosin contractile ring assembly
GO:0000922 - spindle pole
GO:0000940 - outer kinetochore

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

911721

POLO
Serine/threonine-protein kinase polo

2

17

Small-scale

0.812

High

911748

Q95TN8
Serine/threonine-protein kinase greatwall

1

18

Small-scale

0.724

High

911741

SPEN
Protein split ends

1

1

High-throughput

0.698

High

911806

DDB1
DNA damage-binding protein 1

1

8

High-throughput

0.698

High

55628

A1Z9I5
Rac GTPase-activating protein 1

1

13

Small-scale

0.680

High

911726

MTRM
Protein matrimony

4

0

Small-scale

0.675

High

654840

MA205
205 kDa microtubule-associated protein

4

4

Small-scale

0.672

High

911782

AURKB
Aurora kinase B

1

19

Small-scale

0.647

High

356641

PLK4
Serine/threonine-protein kinase PLK4

1

16

High-throughput

0.621

High

911735

Q7KT38
non-specific serine/threonine protein kinase

1

19

High-throughput

0.621

High

451741

NOTCH
Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein]

1

10

High-throughput

0.618

High

633120

MPIP
M-phase inducer phosphatase

1

3

Small-scale

0.618

High

911784

Q9VP79
FI21431p1

2

1

High-throughput

0.595

High

911778

Q9VJ30
non-specific serine/threonine protein kinase

1

18

High-throughput

0.590

High

911786

CHNMO
Zinc finger protein chinmo

1

4

High-throughput

0.590

High

911795

Q9VX80
Kinesin-like protein unc-104

1

5

High-throughput

0.590

High

911770

Q9VGD3
Defective proboscis extension response 17, isoform A

1

1

High-throughput

0.587

High

911723

CNN
Centrosomin

2

8

Small-scale

0.584

High

303772

DCO
Discs overgrown protein kinase

1

18

High-throughput

0.575

High

823749

SQH
Myosin regulatory light chain sqh

1

20

High-throughput

0.575

High

911722

KC1A
Casein kinase I isoform alpha

1

19

High-throughput

0.575

High

654231

DDX6
ATP-dependent RNA helicase me31b

2

3

High-throughput

0.571

High

911730

Q6NN29
Nuclear fallout, isoform E

1

14

Small-scale

0.561

High

911810

X2JFU3
Uncharacterized protein, isoform E

1

5

High-throughput

0.555

High

911737

MIRO
Mitochondrial Rho GTPase

1

10

Small-scale

0.553

High

911773

Q9VHC3
Blistery, isoform A

2

9

High-throughput

0.543

High

195840

TAP
Basic helix-loop-helix neural transcription factor TAP

1

3

High-throughput

0.541

High

653114

MYOD
Myogenic-determination protein

1

1

High-throughput

0.541

High

911728

OMB
Optomotor-blind protein

1

4

High-throughput

0.541

High

911734

MARS
Guanylate kinase-associated protein mars

1

5

High-throughput

0.541

High

911756

Q9U8L5
Dorsocross1, isoform A

1

4

High-throughput

0.541

High

911754

Q9I7U5
Centrobin, isoform A

1

12

Small-scale

0.536

High

911771

Q9VGU4
FI02822p

1

6

High-throughput

0.536

High

911772

DALMA
Protein dalmatian

1

0

High-throughput

0.518

High

458219

DFD
Homeotic protein deformed

1

7

High-throughput

0.508

High

613683

JRA
Transcription factor Jra

1

9

High-throughput

0.508

High

821822

PSA2
Proteasome subunit alpha type-2

1

17

High-throughput

0.508

High

911761

SIR7
NAD-dependent protein deacetylase Sirt7

1

2

High-throughput

0.508

High

911751

KI10A
Kinesin-like protein Klp10A

1

12

Small-scale

0.501

High

911755

CLASP
CLIP-associating protein

1

9

Small-scale

0.501

High

911738

RS8
Small ribosomal subunit protein eS8

1

1

High-throughput

0.494

High

911762

DCA10
DDB1- and CUL4-associated factor 10 homolog

1

13

High-throughput

0.494

High

911774

Q9VI23
LD40317p

1

5

High-throughput

0.494

High

900578

TAF1
Transcription initiation factor TFIID subunit 1

1

8

High-throughput

0.494

High

911809

AMOS
Basic helix-loop-helix transcription factor amos

1

4

High-throughput

0.494

High

391884

HSP83
Heat shock protein 83

1

20

High-throughput

0.492

High

194930

MBL
Protein muscleblind

1

0

High-throughput

0.486

High

911792

TPPP
Tubulin polymerization-promoting protein homolog

1

0

High-throughput

0.486

High

911752

Q961D7
LD07765p

1

1

High-throughput

0.481

High

911760

Q9V9T4
ATP-dependent chromatin assembly factor large subunit

1

10

High-throughput

0.481

High

911776

Q9VI72
Spindle assembly abnormal 4

1

10

High-throughput

0.481

High

911779

PDM2B
POU domain protein 2, isoform B

1

6

High-throughput

0.481

High

911796

Q9VXJ5
Disco-related, isoform A

1

1

High-throughput

0.481

High

911807

Q9XZ31
Anastral spindle 2, isoform A

1

1

High-throughput

0.481

High

911788

Q9VQS4
Spindly

1

0

Small-scale

0.480

High

911790

Q9VUA5
LD42058p

1

0

Small-scale

0.480

High

911731

Q7JRJ9
Inner centromere protein, isoform A

1

6

Small-scale

0.479

High

911750

Q960D2
SD06673p

1

13

Small-scale

0.479

High

911768

Q9VEV3
Tetratricopeptide repeat protein 1

1

14

High-throughput

0.479

High

911801

Q9W1G7
LD21576p

1

5

Small-scale

0.479

High

911805

Q9W4H9
Fizzy-related protein homolog

1

14

Small-scale

0.479

High

911783

MAEL
Protein maelstrom

1

0

Small-scale

0.458

High

197505

O18363
Knockout

1

1

High-throughput

0.457

High

725853

PDM2A
POU domain protein 2, isoform A

1

6

High-throughput

0.457

High

911747

Q95RV8
LD09043p

1

12

High-throughput

0.457

High

911753

Q9GSZ5
Disco-related protein

1

1

High-throughput

0.457

High

911799

Q9VZU6
BTB-VII protein domain

1

4

High-throughput

0.457

High

704339

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

1

High-throughput

0.445

High

834837

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

1

High-throughput

0.445

High

909850

PFKA
ATP-dependent 6-phosphofructokinase

1

6

High-throughput

0.445

High

911724

ARL2
ADP-ribosylation factor-like protein 2

1

7

High-throughput

0.445

High

911725

ROP
Protein ROP

1

3

High-throughput

0.445

High

911727

ISWI
Chromatin-remodeling complex ATPase chain Iswi

1

11

High-throughput

0.445

High

911729

SARM1
NAD(+) hydrolase sarm1

1

6

High-throughput

0.445

High

911739

Q8MSW0
Isoleucine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.445

High

911744

ENA
Protein enabled

1

5

High-throughput

0.445

High

911745

Q8T8W3
AT21416p

1

7

High-throughput

0.445

High

911757

NOG1
Nucleolar GTP-binding protein 1

1

3

High-throughput

0.445

High

911759

Q9V455
Importin subunit alpha

1

4

High-throughput

0.445

High

911763

Q9VAX8
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.445

High

911765

DDX18
Probable ATP-dependent RNA helicase pitchoune

1

5

High-throughput

0.445

High

911769

ATD3A
ATPase family AAA domain-containing protein 3A homolog

1

20

High-throughput

0.445

High

911775

Q9VI53
LD44267p

1

6

High-throughput

0.445

High

911777

DDX47
ATP-dependent RNA helicase DDX47

1

4

High-throughput

0.445

High

911781

NFS1
Cysteine desulfurase, mitochondrial

1

4

High-throughput

0.445

High

911785

NUBP2
Cytosolic Fe-S cluster assembly factor Nubp2 homolog

1

1

High-throughput

0.445

High

911791

FRL
Formin-like protein

1

1

High-throughput

0.445

High

911798

Q9VZ88
AT07585p

1

4

High-throughput

0.445

High

911808

FL2D
Pre-mRNA-splicing regulator female-lethal(2)D

1

10

Small-scale

0.445

High

55504

A1Z9E4
MIP03776p

1

1

High-throughput

0.439

High

911736

Q7YU88
SD08871p

1

1

High-throughput

0.439

High

911740

Q8MSY6
non-specific serine/threonine protein kinase

1

0

High-throughput

0.438

High

911758

API5
Apoptosis inhibitor 5 homolog

1

0

High-throughput

0.426

High

911767

Q9VEP0
Regulatory protein zeste

1

0

High-throughput

0.426

High

911787

Q9VQI5
Interferon-related developmental regulator 1

1

0

High-throughput

0.426

High

911743

Q8SZX6
LP03146p

1

1

High-throughput

0.417

High

911803

Q9W3X2
Uncharacterized protein, isoform A

1

5

High-throughput

0.417

High

55418

A1Z9E3
Elongation factor Tu

1

5

High-throughput

0.407

High

852167

COPB
Coatomer subunit beta

1

5

High-throughput

0.407

High

911732

Q7JXU4
Nucleolar GTP-binding protein 2

1

3

High-throughput

0.407

High

911733

NUP50
Nuclear pore complex protein Nup50

1

6

High-throughput

0.407

High

911749

Q95WY3
Nucleolar protein 56

1

2

High-throughput

0.407

High

911780

Q9VKC1
IP16805p

1

5

High-throughput

0.407

High

911794

IDH3A
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

1

High-throughput

0.407

High

911797

Q9VXK5
Putative rRNA methyltransferase

1

4

High-throughput

0.407

High

195190

O16048
Kinesin-like protein

1

10

High-throughput

0.381

High

304444

O76904
EG:8D8.1 protein

1

0

High-throughput

0.282

High

911793

Y3380
Uncharacterized protein CG13380

1

0

High-throughput

0.282

High

911802

Q9W3T0
RE73396p

1

0

High-throughput

0.282

High

911764

Q9VB45
GEO07187p1

1

0

High-throughput

0.265

Low

911804

Q9W3Z4
GH18625p

1

0

High-throughput

0.265

Low

911746

Q95RF6
LD34461p

1

0

High-throughput

0.249

Low

911742

Q8SYE7
RE65113p

1

0

High-throughput

0.238

Low

911766

Q9VDK7
Signal recognition particle subunit SRP72

1

0

High-throughput

0.232

Low

911789

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.232

Low

911800

Q9VZU8
Alpha-1,3/1,6-mannosyltransferase ALG2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025