HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: MK08 (P45983)
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Gene: MAPK8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.689

Property	Details
Experiments	19530246, 17145805, 20512932, 19234442
Identification Methods	enzymatic study, pull down, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0019899 - enzyme binding GO:0090398 - cellular senescence
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 143 Hs			1 427
+	Hs
		800797 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		MK08_HUMAN (1-427): 6.2e-164: 469: 100.00
+	Hs
		800792 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		MK08_HUMAN (1-427): 6.2e-164: 469: 100.00
+	Hs
		625560 H2A1H_HUMAN (1-128): 2.85e-66: 198: 92.19		CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23
+	Hs
		391553 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23
+	Hs
		260810 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		MK12_HUMAN (2-379): 2.46e-131: 384: 43.05
+	Hs
		391558 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		MK03_HUMAN (20-359): 5.22e-83: 261: 41.26