Protein: SKI
Ski oncogene (Proto-oncogene c-Ski)

Gene: SKI
Organism: Homo sapiens
Interactions: 162
UniProt ID: P12755

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001843 - neural tube closure

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

555387

SMAD4
Mothers against decapentaplegic homolog 4

20

16

Small-scale

0.988

High

555377

SMAD3
Mothers against decapentaplegic homolog 3

16

16

Small-scale

0.987

High

555400

SMAD2
Mothers against decapentaplegic homolog 2

15

16

Small-scale

0.985

High

555328

SKIL
Ski-like protein

4

2

Small-scale

0.902

High

555401

SMAD1
Mothers against decapentaplegic homolog 1

3

16

Small-scale

0.857

High

555327

SKI
Ski oncogene

2

2

Small-scale

0.768

High

278221

NCOR1
Nuclear receptor corepressor 1

5

4

Small-scale

0.712

High

555417

SIN3A
Paired amphipathic helix protein Sin3a

4

1

Small-scale

0.694

High

188159

HDAC3
Histone deacetylase 3

4

5

Small-scale

0.691

High

555428

RMD5A
E3 ubiquitin-protein transferase RMND5A

3

3

High-throughput

0.650

High

555404

RN111
E3 ubiquitin-protein ligase Arkadia

3

4

Small-scale

0.640

High

555350

TNR3
Tumor necrosis factor receptor superfamily member 3

3

0

High-throughput

0.638

High

555427

WDR26
WD repeat-containing protein 26

3

0

Small-scale

0.628

High

177647

SMAD7
Mothers against decapentaplegic homolog 7

1

16

Small-scale

0.618

High

555419

SMAD5
Mothers against decapentaplegic homolog 5

1

16

Small-scale

0.618

High

555390

SNW1
SNW domain-containing protein 1

2

0

Small-scale

0.614

High

555397

RBP1
RalA-binding protein 1

2

0

High-throughput

0.602

High

555394

NFIX
Nuclear factor 1 X-type

2

7

Small-scale

0.595

High

520500

RARA
Retinoic acid receptor alpha

2

2

Small-scale

0.584

High

517511

GLI3
Transcriptional activator GLI3

1

3

Small-scale

0.573

High

555334

SPI1
Transcription factor PU.1

1

1

Small-scale

0.561

High

555343

PML
Protein PML

1

6

Small-scale

0.561

High

555345

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.561

High

555349

TGFR1
TGF-beta receptor type-1

1

1

Small-scale

0.561

High

555373

UBC9
SUMO-conjugating enzyme UBC9

1

1

Small-scale

0.561

High

555425

HIPK2
Homeodomain-interacting protein kinase 2

1

5

Small-scale

0.561

High

555432

PRD16
Histone-lysine N-methyltransferase PRDM16

2

0

Small-scale

0.559

High

162450

ANM5
Protein arginine N-methyltransferase 5

1

1

Small-scale

0.554

High

519323

MYB
Transcriptional activator Myb

1

0

Small-scale

0.537

High

555358

MECP2
Methyl-CpG-binding protein 2

1

0

Small-scale

0.537

High

369431

AACT
Alpha-1-antichymotrypsin

1

2

High-throughput

0.536

High

555342

SPB3
Serpin B3

1

2

High-throughput

0.536

High

555408

MAEA
E3 ubiquitin-protein transferase MAEA

1

3

High-throughput

0.536

High

555434

GID8
Glucose-induced degradation protein 8 homolog

1

3

High-throughput

0.536

High

555442

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

4

High-throughput

0.536

High

555423

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

0

Small-scale

0.530

High

517448

GLI2
Zinc finger protein GLI2

1

3

Small-scale

0.527

High

555406

UBR3
E3 ubiquitin-protein ligase UBR3

1

0

High-throughput

0.513

High

555410

S1A7A
Protein S100-A7A

1

0

High-throughput

0.513

High

555411

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.513

High

555413

ZMY19
Zinc finger MYND domain-containing protein 19

1

0

High-throughput

0.513

High

555431

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

High-throughput

0.513

High

555435

NLK
Serine/threonine-protein kinase NLK

1

0

High-throughput

0.513

High

555439

MKLN1
Muskelin

1

0

High-throughput

0.513

High

555385

TIF1B
Transcription intermediary factor 1-beta

1

6

Small-scale

0.501

High

555405

ARK2C
E3 ubiquitin-protein ligase ARK2C

1

4

Small-scale

0.500

High

300623

KRT37
Keratin, type I cuticular Ha7

1

1

High-throughput

0.489

High

555354

SPB4
Serpin B4

1

2

High-throughput

0.489

High

136806

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

1

Small-scale

0.479

High

142803

NFIB
Nuclear factor 1 B-type

1

7

High-throughput

0.479

High

181048

AXIN1
Axin-1

1

1

Small-scale

0.479

High

226509

TLX2
T-cell leukemia homeobox protein 2

1

2

High-throughput

0.479

High

323136

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

Small-scale

0.479

High

395397

ESR1
Estrogen receptor

1

4

Small-scale

0.479

High

413093

P53
Cellular tumor antigen p53

1

2

Small-scale

0.479

High

420324

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

2

Small-scale

0.479

High

424749

ADT2
ADP/ATP translocase 2

1

3

Small-scale

0.479

High

429214

JUN
Transcription factor Jun

1

1

Small-scale

0.479

High

442563

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.479

High

443640

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

1

Small-scale

0.479

High

457197

TBB5
Tubulin beta chain

1

2

Small-scale

0.479

High

473753

NFIC
Nuclear factor 1 C-type

1

7

High-throughput

0.479

High

519697

ANDR
Androgen receptor

1

4

High-throughput

0.479

High

534564

BIP
Endoplasmic reticulum chaperone BiP

1

3

Small-scale

0.479

High

536393

HSP7C
Heat shock cognate 71 kDa protein

1

2

Small-scale

0.479

High

550099

PABP1
Polyadenylate-binding protein 1

1

2

Small-scale

0.479

High

552103

ADT3
ADP/ATP translocase 3

1

3

Small-scale

0.479

High

555330

ITB4
Integrin beta-4

1

2

Small-scale

0.479

High

555332

HSP76
Heat shock 70 kDa protein 6

1

2

Small-scale

0.479

High

555335

TCPA
T-complex protein 1 subunit alpha

1

1

Small-scale

0.479

High

555336

NUCL
Nucleolin

1

2

Small-scale

0.479

High

555341

TEAD1
Transcriptional enhancer factor TEF-1

1

1

Small-scale

0.479

High

555346

AKT2
RAC-beta serine/threonine-protein kinase

1

1

Small-scale

0.479

High

555347

HS71L
Heat shock 70 kDa protein 1-like

1

2

Small-scale

0.479

High

555351

HSPA9
Stress-70 protein, mitochondrial

1

4

Small-scale

0.479

High

555359

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

2

Small-scale

0.479

High

555363

KLF3
Krueppel-like factor 3

1

3

High-throughput

0.479

High

555364

EPIPL
Epiplakin

1

3

Small-scale

0.479

High

555365

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.479

High

555370

H4
Histone H4

1

1

High-throughput

0.479

High

555372

RACK1
Small ribosomal subunit protein RACK1

1

1

Small-scale

0.479

High

555374

TBA1B
Tubulin alpha-1B chain

1

3

Small-scale

0.479

High

555375

TBA4A
Tubulin alpha-4A chain

1

3

Small-scale

0.479

High

555378

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

2

Small-scale

0.479

High

555383

NFIA
Nuclear factor 1 A-type

1

7

High-throughput

0.479

High

555386

PABP4
Polyadenylate-binding protein 4

1

2

Small-scale

0.479

High

555391

TBB2A
Tubulin beta-2A chain

1

2

Small-scale

0.479

High

555393

MVP
Major vault protein

1

2

Small-scale

0.479

High

555395

PLEC
Plectin

1

2

Small-scale

0.479

High

555396

STK38
Serine/threonine-protein kinase 38

1

4

Small-scale

0.479

High

555399

TEAD4
Transcriptional enhancer factor TEF-3

1

1

Small-scale

0.479

High

555403

ACTBL
Beta-actin-like protein 2

1

1

Small-scale

0.479

High

555407

TBA1A
Tubulin alpha-1A chain

1

3

Small-scale

0.479

High

555409

MOB1B
MOB kinase activator 1B

1

1

Small-scale

0.479

High

555412

RBCC1
RB1-inducible coiled-coil protein 1

1

2

Small-scale

0.479

High

555415

CIC
Protein capicua homolog

1

2

High-throughput

0.479

High

555416

RANB9
Ran-binding protein 9

1

1

Small-scale

0.479

High

555420

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

555421

MEP50
Methylosome protein WDR77

1

1

High-throughput

0.479

High

555422

TBB6
Tubulin beta-6 chain

1

2

Small-scale

0.479

High

555426

SAV1
Protein salvador homolog 1

1

5

Small-scale

0.479

High

555429

MOB1A
MOB kinase activator 1A

1

1

Small-scale

0.479

High

555430

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

4

Small-scale

0.479

High

555433

LATS2
Serine/threonine-protein kinase LATS2

1

4

Small-scale

0.479

High

555437

KLF15
Krueppel-like factor 15

1

1

High-throughput

0.479

High

555440

TRI33
E3 ubiquitin-protein ligase TRIM33

1

6

High-throughput

0.479

High

555441

ST38L
Serine/threonine-protein kinase 38-like

1

4

Small-scale

0.479

High

209945

CRX
Cone-rod homeobox protein

1

0

High-throughput

0.458

High

211532

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

0

Small-scale

0.458

High

252411

DIAP1
Protein diaphanous homolog 1

1

0

Small-scale

0.458

High

290847

PPM1B
Protein phosphatase 1B

1

0

Small-scale

0.458

High

358594

LDHA
L-lactate dehydrogenase A chain

1

0

Small-scale

0.458

High

428586

RLA0
Large ribosomal subunit protein uL10

1

0

Small-scale

0.458

High

468010

HS90B
Heat shock protein HSP 90-beta

1

0

Small-scale

0.458

High

532321

CH60
60 kDa heat shock protein, mitochondrial

1

0

Small-scale

0.458

High

539509

PYGB
Glycogen phosphorylase, brain form

1

0

Small-scale

0.458

High

550812

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.458

High

555329

GATA1
Erythroid transcription factor

1

0

Small-scale

0.458

High

555333

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

Small-scale

0.458

High

555337

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

Small-scale

0.458

High

555338

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.458

High

555340

PYR1
Multifunctional protein CAD

1

0

Small-scale

0.458

High

555344

RL12
Large ribosomal subunit protein uL11

1

0

Small-scale

0.458

High

555348

RL4
Large ribosomal subunit protein uL4

1

0

Small-scale

0.458

High

555353

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

Small-scale

0.458

High

555357

RL14
Large ribosomal subunit protein eL14

1

0

Small-scale

0.458

High

555361

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

Small-scale

0.458

High

555362

GSC
Homeobox protein goosecoid

1

0

High-throughput

0.458

High

555366

DCAF7
DDB1- and CUL4-associated factor 7

1

0

Small-scale

0.458

High

555367

RS16
Small ribosomal subunit protein uS9

1

0

Small-scale

0.458

High

555368

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

Small-scale

0.458

High

555369

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

555371

RL30
Large ribosomal subunit protein eL30

1

0

Small-scale

0.458

High

555376

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.458

High

555379

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

0

Small-scale

0.458

High

555380

PRDX1
Peroxiredoxin-1

1

0

Small-scale

0.458

High

555381

RL18
Large ribosomal subunit protein eL18

1

0

Small-scale

0.458

High

555382

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

Small-scale

0.458

High

555384

MERTK
Tyrosine-protein kinase Mer

1

0

Small-scale

0.458

High

555388

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

555392

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

Small-scale

0.458

High

555398

SIX1
Homeobox protein SIX1

1

0

Small-scale

0.458

High

555402

TBR1
T-box brain protein 1

1

0

High-throughput

0.458

High

555414

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.458

High

555418

EYA3
Protein phosphatase EYA3

1

0

Small-scale

0.458

High

555424

SHRPN
Sharpin

1

0

Small-scale

0.458

High

555436

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

555389

HDAC1
Histone deacetylase 1

1

5

Small-scale

0.445

High

555443

NCOR2
Nuclear receptor corepressor 2

1

3

Small-scale

0.445

High

551940

ADT1
ADP/ATP translocase 1

1

3

Small-scale

0.437

High

555331

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

2

Small-scale

0.437

High

555339

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

1

Small-scale

0.437

High

555355

TCPG
T-complex protein 1 subunit gamma

1

1

Small-scale

0.437

High

555438

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

3

Small-scale

0.437

High

516741

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.426

High

467691

CEL2A
Chymotrypsin-like elastase family member 2A

1

0

High-throughput

0.279

Low

555444

HS3S4
Heparan sulfate glucosamine 3-O-sulfotransferase 4

1

0

High-throughput

0.279

Low

555352

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

Small-scale

0.249

Low

555356

EFTU
Elongation factor Tu, mitochondrial

1

0

Small-scale

0.249

Low

555360

COPB
Coatomer subunit beta

1

0

Small-scale

0.249

Low

555445

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025