HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: MCM2 (P49736)
DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
Gene: MCM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	25963833, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~MCM2_N
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly GO:0019899 - enzyme binding and 1 others more... GO:0042393 - histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 143 Hs			1 904
+	Hs
		832655 H2A1A_HUMAN (1-125): 8.26e-67: 200: 92.00		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832672 H2A1J_HUMAN (1-128): 1.45e-66: 199: 92.19		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832567 H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832623 H2A1C_HUMAN (1-129): 5.04e-66: 198: 92.25		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832648 H2A1H_HUMAN (1-128): 2.85e-66: 198: 92.19		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		594831 H2A1D_HUMAN (1-129): 1.02e-65: 197: 90.70		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		832548 H2A3_HUMAN (1-129): 5.88e-66: 197: 91.47		MCM2_HUMAN (1-904): 0: 1078: 100.00
+	Hs
		555318 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		MCM4_HUMAN (2-885): 0: 847: 28.42
+	Hs
		391569 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		MCM4_HUMAN (2-885): 0: 847: 28.42
+	Hs
		555319 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708736 H2A1A_HUMAN (1-125): 8.26e-67: 200: 92.00		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708748 H2A1J_HUMAN (1-128): 1.45e-66: 199: 92.19		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708697 H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708718 H2A1C_HUMAN (1-129): 5.04e-66: 198: 92.25		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708733 H2A1H_HUMAN (1-128): 2.85e-66: 198: 92.19		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		391570 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		594826 H2A1D_HUMAN (1-129): 1.02e-65: 197: 90.70		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		708693 H2A3_HUMAN (1-129): 5.88e-66: 197: 91.47		MCM5_HUMAN (169-902): 0: 768: 29.43
+	Hs
		555462 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		MCM6_HUMAN (186-817): 0: 710: 31.18
+	Hs
		555320 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		MCM7_HUMAN (188-886): 0: 707: 27.35