HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: SMCA4 (P51532)
Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
Gene: SMARCA4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	28242625, 24413084, 16932743, 20224553
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 143 Hs			1 1647
+	Hs
		555358 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		SMCA2_HUMAN (1-1647): 0: 980: 71.69
+	Hs
		229296 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		SMCA5_HUMAN (626-1631): 0: 835: 27.41
+	Hs
		555306 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		SMCA1_HUMAN (639-1619): 0: 832: 28.82
+	Hs
		229433 H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97		SMCA5_HUMAN (626-1631): 0: 835: 27.41
+	Hs
		229279 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		SMCA5_HUMAN (626-1631): 0: 835: 27.41
+	Hs
		229254 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		SMCA5_HUMAN (626-1631): 0: 835: 27.41
+	Hs
		470278 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		SMCA1_HUMAN (639-1619): 0: 832: 28.82
+	Hs
		260763 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		SMCA1_HUMAN (639-1619): 0: 832: 28.82
+	Hs
		555466 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		CHD4_HUMAN (482-1630): 0: 722: 23.79
+	Hs
		555654 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		CHD8_HUMAN (13-1523): 0: 711: 21.11
+	Hs
		1059717 H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97		CHD4_HUMAN (482-1630): 0: 722: 23.79
+	Hs
		1059795 H2A1H_HUMAN (1-128): 2.85e-66: 198: 92.19		CHD4_HUMAN (482-1630): 0: 722: 23.79
+	Hs
		391704 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		CHD4_HUMAN (482-1630): 0: 722: 23.79
+	Hs
		470387 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		CHD4_HUMAN (482-1630): 0: 722: 23.79
+	Hs
		1059647 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		CHD4_HUMAN (482-1630): 0: 722: 23.79
+	Hs
		1018640 H2A1H_HUMAN (1-128): 2.85e-66: 198: 92.19		CHD3_HUMAN (300-1646): 0: 711: 20.80
+	Hs
		391675 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		CHD3_HUMAN (300-1646): 0: 711: 20.80
+	Hs
		391915 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		CHD8_HUMAN (13-1523): 0: 711: 21.11
+	Hs
		391728 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		CHD9_HUMAN (67-1534): 0: 702: 20.82
+	Hs
		151474 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		CHD2_HUMAN (343-1449): 0: 682: 26.93