HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: RS27A (P62979)
Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)]
Gene: RPS27A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	28514442, 33961781, 34349018
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0070062 - extracellular exosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 143 Hs			1 156
+	Hs
		391643 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		RS27A_HUMAN (1-156): 3.55e-76: 225: 100.00
+	Hs
		470331 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		RS27A_HUMAN (1-156): 3.55e-76: 225: 100.00
+	Hs
		924034 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		RS27A_HUMAN (1-156): 3.55e-76: 225: 100.00
+	Hs
		924049 H2A3_HUMAN (1-129): 5.88e-66: 197: 91.47		RS27A_HUMAN (1-156): 3.55e-76: 225: 100.00
+	Hs
		260831 H2AY_HUMAN (1-142): 1.74e-61: 194: 60.69		RS27A_HUMAN (1-156): 3.55e-76: 225: 100.00
+	Hs
		555404 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		RL40_HUMAN (1-125): 5.33e-44: 142: 64.80
+	Hs
		474911 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		UBB_HUMAN (1-76): 6.65e-36: 125: 100.00
+	Hs
		924397 H2A1J_HUMAN (1-128): 1.45e-66: 199: 92.19		RL40_HUMAN (1-125): 5.33e-44: 142: 64.80
+	Hs
		924374 H2A1C_HUMAN (1-129): 5.04e-66: 198: 92.25		RL40_HUMAN (1-125): 5.33e-44: 142: 64.80
+	Hs
		924387 H2A1H_HUMAN (1-128): 2.85e-66: 198: 92.19		RL40_HUMAN (1-125): 5.33e-44: 142: 64.80
+	Hs
		391644 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		RL40_HUMAN (1-125): 5.33e-44: 142: 64.80
+	Hs
		470332 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		RL40_HUMAN (1-125): 5.33e-44: 142: 64.80
+	Hs
		924322 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		RL40_HUMAN (1-125): 5.33e-44: 142: 64.80
+	Hs
		924334 H2A3_HUMAN (1-129): 5.88e-66: 197: 91.47		RL40_HUMAN (1-125): 5.33e-44: 142: 64.80
+	Rn
		474085 H2A2A_RAT (1-129): 7e-66: 197: 91.47		UBC_RAT (1-119): 1.57e-36: 134: 68.29
+	At
		1092092 H2A6_ARATH (1-128): 3.9e-61: 186: 73.64		UBQ3_ARATH (1-77): 2.19e-35: 126: 94.81
+	Sc
		392251 H2A2_YEAST (16-124): 4.61e-53: 165: 82.57		RL40A_YEAST (1-125): 2.07e-42: 139: 64.00
+	Dm
		950447 H2A_DROME (17-124): 3.82e-60: 183: 90.74		R9PY16_DROME (1-68): 7.11e-29: 108: 91.18