HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: CHD1L (Q86WJ1)
Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1)
Gene: CHD1L

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	28514442, 33961781, 19666485
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response GO:0035861 - site of double-strand break GO:0090734 - site of DNA damage
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 143 Hs			1 897
+	Hs
		1151349 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		CHD1L_HUMAN (1-897): 0: 850: 100.00
+	Hs
		1185203 H2A3_HUMAN (1-129): 5.88e-66: 197: 91.47		CHD1L_HUMAN (1-897): 0: 850: 100.00
+	Hs
		555654 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		CHD8_HUMAN (1-856): 0: 643: 27.69
+	Hs
		391915 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		CHD8_HUMAN (1-856): 0: 643: 27.69
+	Hs
		391728 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		CHD9_HUMAN (1-856): 0: 636: 28.03
+	Hs
		229296 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		SMCA5_HUMAN (9-786): 0: 603: 32.60
+	Hs
		555306 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		SMCA1_HUMAN (35-786): 0: 594: 32.63
+	Hs
		151474 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		CHD2_HUMAN (11-797): 0: 610: 33.05
+	Hs
		555466 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		CHD4_HUMAN (18-775): 0: 584: 32.19
+	Hs
		229433 H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97		SMCA5_HUMAN (9-786): 0: 603: 32.60
+	Hs
		229279 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		SMCA5_HUMAN (9-786): 0: 603: 32.60
+	Hs
		470278 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		SMCA1_HUMAN (35-786): 0: 594: 32.63
+	Hs
		1018640 H2A1H_HUMAN (1-128): 2.85e-66: 198: 92.19		CHD3_HUMAN (21-792): 0: 590: 31.44
+	Hs
		391675 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		CHD3_HUMAN (21-792): 0: 590: 31.44
+	Hs
		555359 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		SMCA4_HUMAN (3-782): 0: 567: 29.03
+	Hs
		1059717 H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97		CHD4_HUMAN (18-775): 0: 584: 32.19
+	Hs
		1059795 H2A1H_HUMAN (1-128): 2.85e-66: 198: 92.19		CHD4_HUMAN (18-775): 0: 584: 32.19
+	Hs
		391704 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		CHD4_HUMAN (18-775): 0: 584: 32.19
+	Hs
		470387 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		CHD4_HUMAN (18-775): 0: 584: 32.19
+	Hs
		555358 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		SMCA2_HUMAN (3-782): 8.8e-177: 555: 28.77