Protein: SKIL
Ski-like protein (Ski-related oncogene) (Ski-related protein)

Gene: SKIL
Organism: Homo sapiens
Interactions: 130
UniProt ID: P12757

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001669 - acrosomal vesicle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

555477

SMAD4
Mothers against decapentaplegic homolog 4

9

16

Small-scale

0.971

High

555490

SMAD2
Mothers against decapentaplegic homolog 2

9

16

Small-scale

0.971

High

555467

SMAD3
Mothers against decapentaplegic homolog 3

8

16

Small-scale

0.964

High

555328

SKI
Ski oncogene

4

2

Small-scale

0.902

High

555446

SKIL
Ski-like protein

2

2

Small-scale

0.768

High

278222

NCOR1
Nuclear receptor corepressor 1

3

4

Small-scale

0.674

High

555537

TRI33
E3 ubiquitin-protein ligase TRIM33

4

6

Small-scale

0.672

High

555499

RN111
E3 ubiquitin-protein ligase Arkadia

3

4

Small-scale

0.664

High

555532

VPS28
Vacuolar protein sorting-associated protein 28 homolog

3

1

High-throughput

0.660

High

451111

NFL
Neurofilament light polypeptide

2

2

High-throughput

0.628

High

555491

SMAD1
Mothers against decapentaplegic homolog 1

1

16

Small-scale

0.618

High

555469

DEUP1
Deuterosome assembly protein 1

2

1

High-throughput

0.606

High

555478

HDAC1
Histone deacetylase 1

2

5

Small-scale

0.584

High

555453

XPA
DNA repair protein complementing XP-A cells

2

0

High-throughput

0.580

High

555542

NCOR2
Nuclear receptor corepressor 2

1

3

Small-scale

0.573

High

291747

STK16
Serine/threonine-protein kinase 16

1

1

High-throughput

0.573

High

555471

TLE5
TLE family member 5

1

1

High-throughput

0.573

High

395398

ESR1
Estrogen receptor

1

4

Small-scale

0.561

High

217048

MS18B
Protein Mis18-beta

1

0

High-throughput

0.549

High

555522

NXF3
Nuclear RNA export factor 3

1

0

High-throughput

0.549

High

555540

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.549

High

213788

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

Small-scale

0.529

High

555459

RS27
Small ribosomal subunit protein eS27

1

0

High-throughput

0.518

High

555468

ZN200
Zinc finger protein 200

1

0

High-throughput

0.518

High

555495

SMUG1
Single-strand selective monofunctional uracil DNA glycosylase

1

0

High-throughput

0.518

High

474436

VIME
Vimentin

1

2

High-throughput

0.515

High

555451

PECA1
Platelet endothelial cell adhesion molecule

1

1

High-throughput

0.515

High

555489

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

0

High-throughput

0.513

High

555526

SIAS
N-acetylneuraminate-9-phosphate synthase

1

0

High-throughput

0.513

High

248661

PEPL
Periplakin

1

3

High-throughput

0.508

High

297428

PIAS1
E3 SUMO-protein ligase PIAS1

1

2

High-throughput

0.508

High

472429

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.508

High

555464

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.508

High

555470

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

2

High-throughput

0.508

High

555505

HIPK1
Homeodomain-interacting protein kinase 1

1

5

High-throughput

0.508

High

555507

PIAS4
E3 SUMO-protein ligase PIAS4

1

2

High-throughput

0.508

High

555508

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

1

High-throughput

0.508

High

555518

TRI62
E3 ubiquitin-protein ligase TRIM62

1

1

High-throughput

0.508

High

555523

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

1

High-throughput

0.508

High

555525

HEYL
Hairy/enhancer-of-split related with YRPW motif-like protein

1

1

High-throughput

0.508

High

555529

ZMYM2
Zinc finger MYM-type protein 2

1

1

High-throughput

0.508

High

555535

TTF2
Transcription termination factor 2

1

1

High-throughput

0.508

High

555536

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

3

High-throughput

0.508

High

555541

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

1

High-throughput

0.508

High

555543

PIAS3
E3 SUMO-protein ligase PIAS3

1

2

High-throughput

0.508

High

249086

DSCAM
Cell adhesion molecule DSCAM

1

2

High-throughput

0.494

High

245856

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.493

High

301319

WFS1
Wolframin

1

0

High-throughput

0.493

High

555503

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

129646

CBX4
E3 SUMO-protein ligase CBX4

1

0

High-throughput

0.486

High

320373

SASH1
SAM and SH3 domain-containing protein 1

1

0

High-throughput

0.486

High

339131

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

0

High-throughput

0.486

High

522578

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

0

High-throughput

0.486

High

555447

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.486

High

555450

GLNA
Glutamine synthetase

1

0

High-throughput

0.486

High

555454

FBLN1
Fibulin-1

1

0

High-throughput

0.486

High

555455

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.486

High

555457

PRS7
26S proteasome regulatory subunit 7

1

0

High-throughput

0.486

High

555465

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.486

High

555466

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

0

High-throughput

0.486

High

555474

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.486

High

555479

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

High-throughput

0.486

High

555486

SNX17
Sorting nexin-17

1

0

High-throughput

0.486

High

555487

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.486

High

555492

ZBTB6
Zinc finger and BTB domain-containing protein 6

1

0

High-throughput

0.486

High

555494

SVEP1
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

1

0

High-throughput

0.486

High

555498

CAMP1
Calmodulin-regulated spectrin-associated protein 1

1

0

High-throughput

0.486

High

555501

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.486

High

555502

CXXC5
CXXC-type zinc finger protein 5

1

0

High-throughput

0.486

High

555504

THAP5
THAP domain-containing protein 5

1

0

High-throughput

0.486

High

555509

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

0

High-throughput

0.486

High

555512

MORC4
MORC family CW-type zinc finger protein 4

1

0

High-throughput

0.486

High

555513

TSK
Tsukushi

1

0

High-throughput

0.486

High

555516

UIMC1
BRCA1-A complex subunit RAP80

1

0

High-throughput

0.486

High

555528

I36RA
Interleukin-36 receptor antagonist protein

1

0

High-throughput

0.486

High

555530

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

0

High-throughput

0.486

High

555534

FAF1
FAS-associated factor 1

1

0

High-throughput

0.486

High

555538

TRAK1
Trafficking kinesin-binding protein 1

1

0

High-throughput

0.486

High

555483

MVP
Major vault protein

1

2

High-throughput

0.481

High

555514

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

2

High-throughput

0.481

High

142804

NFIB
Nuclear factor 1 B-type

1

7

High-throughput

0.479

High

181049

AXIN1
Axin-1

1

1

Small-scale

0.479

High

442564

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.479

High

473754

NFIC
Nuclear factor 1 C-type

1

7

High-throughput

0.479

High

517512

GLI3
Transcriptional activator GLI3

1

3

Small-scale

0.479

High

519698

ANDR
Androgen receptor

1

4

High-throughput

0.479

High

555456

PML
Protein PML

1

6

Small-scale

0.479

High

555458

TGFR1
TGF-beta receptor type-1

1

1

Small-scale

0.479

High

555460

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

4

Small-scale

0.479

High

555462

H4
Histone H4

1

1

High-throughput

0.479

High

555472

EP300
Histone acetyltransferase p300

1

2

Small-scale

0.479

High

555473

NFIA
Nuclear factor 1 A-type

1

7

High-throughput

0.479

High

555485

NFIX
Nuclear factor 1 X-type

1

7

High-throughput

0.479

High

555500

ARK2C
E3 ubiquitin-protein ligase ARK2C

1

4

Small-scale

0.479

High

555517

SIN3A
Paired amphipathic helix protein Sin3a

1

1

Small-scale

0.479

High

555519

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

4

Small-scale

0.479

High

555520

ING2
Inhibitor of growth protein 2

1

1

Small-scale

0.479

High

555524

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

4

Small-scale

0.479

High

555533

FZR1
Fizzy-related protein homolog

1

2

Small-scale

0.479

High

555448

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

2

High-throughput

0.470

High

555496

Q548N1
Vacuolar protein sorting-associated protein 28 homolog

1

1

High-throughput

0.470

High

555449

NID1
Nidogen-1

1

2

High-throughput

0.464

High

555475

PAPP1
Pappalysin-1

1

1

High-throughput

0.464

High

555480

NID2
Nidogen-2

1

2

High-throughput

0.464

High

555493

PSG3
Pregnancy-specific beta-1-glycoprotein 3

1

1

High-throughput

0.464

High

555521

ZN106
Zinc finger protein 106

1

1

High-throughput

0.464

High

555452

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

555463

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

555531

ZMYM5
Zinc finger MYM-type protein 5

1

1

High-throughput

0.457

High

555544

X5D7R7
Major vault protein

1

2

High-throughput

0.457

High

555481

SPRL1
SPARC-like protein 1

1

2

High-throughput

0.439

High

555527

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

555497

M3K19
Mitogen-activated protein kinase kinase kinase 19

1

1

High-throughput

0.437

High

555511

RBCC1
RB1-inducible coiled-coil protein 1

1

2

Small-scale

0.437

High

555476

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

High-throughput

0.426

High

555510

Q8N4S1
SPARC-like protein 1

1

2

High-throughput

0.417

High

353667

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.316

High

207788

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

0

High-throughput

0.265

Low

303399

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.265

Low

464103

TPM2
Tropomyosin beta chain

1

0

High-throughput

0.265

Low

471576

CO4A2

1

0

High-throughput

0.265

Low

555461

TFPI2
Tissue factor pathway inhibitor 2

1

0

High-throughput

0.265

Low

555482

KRT81
Keratin, type II cuticular Hb1

1

0

High-throughput

0.265

Low

555484

GOGB1
Golgin subfamily B member 1

1

0

High-throughput

0.265

Low

555506

CHSS2
Chondroitin sulfate synthase 2

1

0

High-throughput

0.265

Low

555515

P5CR2
Pyrroline-5-carboxylate reductase 2

1

0

High-throughput

0.265

Low

555539

THS7A
Thrombospondin type-1 domain-containing protein 7A [Cleaved into: Thrombospondin type-1 domain-containing protein 7A, soluble form]

1

0

High-throughput

0.265

Low

555488

EEA1
Early endosome antigen 1

1

0

High-throughput

0.249

Low

328222

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025