HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	21676867, 26936624
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 143 Hs			1 336
+	Hs
		1216249 H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		1151374 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		1185208 H2A3_HUMAN (1-129): 5.88e-66: 197: 91.47		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		391856 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		470514 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		555425 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		391666 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Hs
		555627 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		555322 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		555617 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		391879 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		470533 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		391572 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		470285 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		717932 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		717876 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		555327 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		391861 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		391581 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		551444 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		RAG1_HUMAN (42-197): 1.72e-29: 121: 20.51