Protein: SPTN2
Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)

Gene: SPTN2, SPTBN2
Organism: Homo sapiens
Interactions: 160
UniProt ID: O15020

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005543 - phospholipid binding
GO:0005615 - extracellular space
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

174755

SPTN1
Spectrin alpha chain, non-erythrocytic 1

3

18

Small-scale

0.829

High

174733

ACTZ
Alpha-centractin

2

20

Small-scale

0.804

High

174729

ACTB
Actin, cytoplasmic 1

2

20

Small-scale

0.778

High

174744

SPTB2
Spectrin beta chain, non-erythrocytic 1

2

20

High-throughput

0.754

High

123506

MYO1C
Unconventional myosin-Ic

1

20

High-throughput

0.691

High

174704

FLNA
Filamin-A

1

19

High-throughput

0.691

High

174713

MYH9
Myosin-9

1

13

High-throughput

0.691

High

174718

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

11

High-throughput

0.691

High

174745

ANK2
Ankyrin-2

1

20

High-throughput

0.691

High

174788

MY18A
Unconventional myosin-XVIIIa

1

20

High-throughput

0.691

High

174796

MYO19
Unconventional myosin-XIX

1

17

High-throughput

0.691

High

174685

RASK
GTPase KRas

3

20

High-throughput

0.640

High

174688

LCK
Tyrosine-protein kinase Lck

1

18

High-throughput

0.618

High

174692

LYN
Tyrosine-protein kinase Lyn

1

18

High-throughput

0.618

High

174752

ANK3
Ankyrin-3

1

20

High-throughput

0.618

High

174675

OBSL1
Obscurin-like protein 1

2

20

High-throughput

0.584

High

174684

RASN
GTPase NRas

2

20

High-throughput

0.584

High

174717

YAP1
Transcriptional coactivator YAP1

2

14

High-throughput

0.584

High

174739

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

174810

ANLN
Anillin

2

12

High-throughput

0.584

High

174754

TBB3
Tubulin beta-3 chain

1

2

High-throughput

0.575

High

174773

TBA1A
Tubulin alpha-1A chain

1

5

High-throughput

0.575

High

174695

TAU
Microtubule-associated protein tau

2

17

High-throughput

0.571

High

174771

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.553

High

174680

PCNT
Pericentrin

1

20

High-throughput

0.541

High

174689

ADRB2
Beta-2 adrenergic receptor

1

3

High-throughput

0.541

High

174706

APC
Adenomatous polyposis coli protein

1

20

High-throughput

0.541

High

174710

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.536

High

174719

CAZA2
F-actin-capping protein subunit alpha-2

1

9

High-throughput

0.536

High

174726

DAPK1
Death-associated protein kinase 1

1

20

High-throughput

0.536

High

174737

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

12

High-throughput

0.536

High

174749

CALD1
Caldesmon

1

20

High-throughput

0.536

High

174756

SCRB2
Lysosome membrane protein 2

1

3

High-throughput

0.536

High

174779

SYNPO
Synaptopodin

1

17

High-throughput

0.536

High

174783

TBCK
TBC domain-containing protein kinase-like protein

1

15

High-throughput

0.536

High

174791

KIFA3
Kinesin-associated protein 3

1

10

High-throughput

0.536

High

174821

NEMO
NF-kappa-B essential modulator

1

20

High-throughput

0.536

High

164783

UN13B
Protein unc-13 homolog B

1

4

Small-scale

0.527

High

174690

CATL1
Procathepsin L

1

6

High-throughput

0.515

High

174691

CATB
Cathepsin B

1

10

High-throughput

0.515

High

174698

IFM1
Interferon-induced transmembrane protein 1

1

7

High-throughput

0.515

High

174707

DPP4
Dipeptidyl peptidase 4

1

4

High-throughput

0.515

High

174746

IFM3
Interferon-induced transmembrane protein 3

1

7

High-throughput

0.515

High

174786

CLC4D
C-type lectin domain family 4 member D

1

10

High-throughput

0.515

High

174817

CLC4E
C-type lectin domain family 4 member E

1

10

High-throughput

0.515

High

174751

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.513

High

174777

ABRA
Actin-binding Rho-activating protein

1

0

High-throughput

0.513

High

174799

SORT
Sortilin

1

0

High-throughput

0.513

High

174811

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

174683

CHK2
Serine/threonine-protein kinase Chk2

1

3

High-throughput

0.489

High

174714

MLH1
DNA mismatch repair protein Mlh1

1

5

High-throughput

0.489

High

174758

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

7

High-throughput

0.489

High

174781

BHE23
Class E basic helix-loop-helix protein 23

1

6

High-throughput

0.489

High

174784

HASP
Serine/threonine-protein kinase haspin

1

3

High-throughput

0.489

High

174795

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

5

High-throughput

0.489

High

126366

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

156700

CTRO
Citron Rho-interacting kinase

1

19

High-throughput

0.479

High

174670

TMPS2
Transmembrane protease serine 2

1

6

High-throughput

0.479

High

174671

PRC1
Protein regulator of cytokinesis 1

1

20

High-throughput

0.479

High

174672

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.479

High

174677

FLOT1
Flotillin-1

1

6

High-throughput

0.479

High

174678

ZFPL1
Zinc finger protein-like 1

1

4

High-throughput

0.479

High

174681

DIRA3
GTP-binding protein Di-Ras3

1

9

High-throughput

0.479

High

174686

TFR1
Transferrin receptor protein 1

1

3

High-throughput

0.479

High

174687

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

174693

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

174696

LAMP1
Lysosome-associated membrane glycoprotein 1

1

9

High-throughput

0.479

High

174697

CADH1
Cadherin-1

1

9

High-throughput

0.479

High

174699

LAMP2
Lysosome-associated membrane glycoprotein 2

1

9

High-throughput

0.479

High

174700

CO6
Complement component C6

1

2

High-throughput

0.479

High

174702

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

174705

GCSP
Glycine dehydrogenase

1

5

High-throughput

0.479

High

174709

MARCS
Myristoylated alanine-rich C-kinase substrate

1

10

High-throughput

0.479

High

174716

RS10
Small ribosomal subunit protein eS10

1

7

High-throughput

0.479

High

174720

SOX2
Transcription factor SOX-2

1

7

High-throughput

0.479

High

174722

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

2

High-throughput

0.479

High

174723

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.479

High

174724

RAB5C
Ras-related protein Rab-5C

1

9

High-throughput

0.479

High

174725

MECP2
Methyl-CpG-binding protein 2

1

8

High-throughput

0.479

High

174727

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

8

High-throughput

0.479

High

174730

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

174731

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

174732

RAB2A
Ras-related protein Rab-2A

1

7

High-throughput

0.479

High

174734

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

174735

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

174738

ARF6
ADP-ribosylation factor 6

1

3

High-throughput

0.479

High

174740

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

174743

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

174747

CAV1
Caveolin-1

1

15

High-throughput

0.479

High

174748

K1C17
Keratin, type I cytoskeletal 17

1

12

High-throughput

0.479

High

174750

TFCP2
Alpha-globin transcription factor CP2

1

4

High-throughput

0.479

High

174753

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

20

Small-scale

0.479

High

174759

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

174760

KIF14
Kinesin-like protein KIF14

1

13

High-throughput

0.479

High

174761

RAB35
Ras-related protein Rab-35

1

9

High-throughput

0.479

High

174763

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

174765

OCLN
Occludin

1

5

High-throughput

0.479

High

174767

MIDN
Midnolin

1

3

High-throughput

0.479

High

174768

RN123
E3 ubiquitin-protein ligase RNF123

1

5

High-throughput

0.479

High

174769

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

174774

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

174778

CXD3
Gap junction delta-3 protein

1

12

High-throughput

0.479

High

174782

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

174785

NUDC2
NudC domain-containing protein 2

1

6

High-throughput

0.479

High

174787

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

7

High-throughput

0.479

High

174789

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

174794

CHM4C
Charged multivesicular body protein 4c

1

19

High-throughput

0.479

High

174800

ANM1
Protein arginine N-methyltransferase 1

1

6

High-throughput

0.479

High

174801

AKAP9
A-kinase anchor protein 9

1

20

High-throughput

0.479

High

174802

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

16

High-throughput

0.479

High

174804

CCDC8
Coiled-coil domain-containing protein 8

1

5

High-throughput

0.479

High

174805

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.479

High

174806

CHM4B
Charged multivesicular body protein 4b

1

19

High-throughput

0.479

High

174807

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

174808

ECT2
Protein ECT2

1

20

High-throughput

0.479

High

174809

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

174816

HDAC6
Protein deacetylase HDAC6

1

18

High-throughput

0.479

High

174818

LAMP3
Lysosome-associated membrane glycoprotein 3

1

9

High-throughput

0.479

High

174770

ATAD2
ATPase family AAA domain-containing protein 2

1

8

High-throughput

0.470

High

154446

CLD4
Claudin-4

1

0

Small-scale

0.458

High

174762

LRC41
Leucine-rich repeat-containing protein 41

1

0

High-throughput

0.458

High

174792

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.458

High

174815

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

174736

STXB1
Syntaxin-binding protein 1

1

5

High-throughput

0.457

High

174813

DISC1
Disrupted in schizophrenia 1 protein

1

8

High-throughput

0.457

High

174814

CELR3
Cadherin EGF LAG seven-pass G-type receptor 3

1

3

Small-scale

0.457

High

174673

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

8

High-throughput

0.445

High

174711

BMI1
Polycomb complex protein BMI-1

1

17

High-throughput

0.445

High

174715

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

9

High-throughput

0.445

High

174728

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.445

High

174764

NF2L2
Nuclear factor erythroid 2-related factor 2

1

6

High-throughput

0.445

High

174780

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.445

High

174790

ESR2
Estrogen receptor beta

1

20

High-throughput

0.445

High

174797

CEP63
Centrosomal protein of 63 kDa

1

20

High-throughput

0.445

High

174798

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

High-throughput

0.445

High

104853

APRIO
Alternative prion protein

1

11

High-throughput

0.437

High

174669

CTDSL
CTD small phosphatase-like protein

1

1

High-throughput

0.437

High

174676

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

174679

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.437

High

174682

TOP3B
DNA topoisomerase 3-beta-1

1

4

High-throughput

0.437

High

174694

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.437

High

174701

RFA2
Replication protein A 32 kDa subunit

1

10

High-throughput

0.437

High

174703

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.437

High

174708

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.437

High

174712

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

174721

LMAN1
Protein ERGIC-53

1

2

High-throughput

0.437

High

174741

DYLT1
Dynein light chain Tctex-type 1

1

4

High-throughput

0.437

High

174757

BOP1
Ribosome biogenesis protein BOP1

1

4

High-throughput

0.437

High

174772

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

1

Small-scale

0.437

High

174775

ZCH18
Zinc finger CCCH domain-containing protein 18

1

11

High-throughput

0.437

High

174793

CK052
Uncharacterized protein C11orf52

1

5

High-throughput

0.437

High

174812

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

10

High-throughput

0.437

High

174674

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

62415

S35F4
Solute carrier family 35 member F4

1

4

High-throughput

0.407

High

174742

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

0

High-throughput

0.279

Low

174766

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

174776

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.279

Low

174803

CF263
Cilia- and flagella-associated protein 263

1

0

High-throughput

0.279

Low

174819

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.279

Low

174820

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025