HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: PCGF1 (Q9BSM1)
Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)
Gene: PCGF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	29985131, 24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 143 Hs			1 259
+	Hs
		391879 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		PCGF1_HUMAN (1-259): 4.13e-82: 248: 100.00
+	Hs
		470533 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		PCGF1_HUMAN (1-259): 4.13e-82: 248: 100.00
+	Hs
		555322 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		391572 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		470285 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		717932 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		717876 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Hs
		555611 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		555425 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		RING1_HUMAN (24-155): 3.14e-32: 123: 20.59
+	Hs
		1216249 H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		1151374 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		1185208 H2A3_HUMAN (1-129): 5.88e-66: 197: 91.47		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		391856 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		470514 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		1087089 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Hs
		1307111 H2A1J_HUMAN (1-128): 1.45e-66: 199: 92.19		TRI31_HUMAN (32-246): 2.35e-32: 124: 17.27
+	Hs
		391666 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		RING1_HUMAN (24-155): 3.14e-32: 123: 20.59
+	Hs
		282515 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		RNF8_HUMAN (24-130): 3e-10: 61.7: 28.04
+	Hs
		282470 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		RNF8_HUMAN (24-130): 3e-10: 61.7: 28.04
+	Hs
		282668 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		RNF8_HUMAN (24-130): 3e-10: 61.7: 28.04