HitPredict

Interactor 1: ITB4 (P16144)
Integrin beta-4 (GP150) (CD antigen CD104)
Gene: ITGB4

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11044453
Identification Methods	far western blotting
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0098609 - cell-cell adhesion
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1822 Hs			1 583
+	Hs
		403794 ITB1_HUMAN (5-719): 0: 620: 34.57		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		396570 ITB3_HUMAN (2-704): 0: 600: 34.02		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		403912 ITB1_HUMAN (5-719): 0: 620: 34.57		ANS1B_HUMAN (39-351): 1.55e-45: 175: 17.96
+	Hs
		396593 ITB3_HUMAN (2-704): 0: 600: 34.02		ANS1B_HUMAN (39-351): 1.55e-45: 175: 17.96
+	Hs
		403792 ITB1_HUMAN (5-719): 0: 620: 34.57		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		396598 ITB3_HUMAN (2-704): 0: 600: 34.02		GULP1_HUMAN (137-418): 7.16e-48: 171: 19.79
+	Mm
		69652 PTPRS_MOUSE (784-1814): 3.98e-71: 267: 11.87		ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86
+	Hs
		616962 PTPRD_HUMAN (901-1740): 1.43e-71: 268: 14.49		BMX_HUMAN (341-582): 1.11e-38: 153: 19.69
+	Hs
		234472 DSCAM_HUMAN (739-1785): 2.9e-42: 172: 11.12		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		396609 ITB2_HUMAN (537-760): 1.13e-14: 81.7: 15.92		VAV_HUMAN (163-578): 1.81e-54: 200: 12.25
+	Hs
		489988 PTPRF_HUMAN (821-1296): 1.34e-26: 121: 14.86		SH2D3_HUMAN (333-582): 8.25e-40: 157: 23.55
+	Mm
		1206647 TENR_MOUSE (468-630): 7.05e-15: 82.8: 33.15		ANS1B_MOUSE (39-364): 1.02e-45: 175: 17.86
+	Hs
		209134 TENR_HUMAN (468-630): 9.08e-15: 82.4: 33.70		NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83
+	Hs
		50508 A1L306_HUMAN (468-630): 1.1e-14: 82.4: 33.70		NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83
+	Mm
		222588 ITB3_MOUSE (579-810): 5.85e-09: 63.2: 8.37		VAV3_MOUSE (190-579): 6.41e-48: 181: 14.39
+	Hs
		639912 ITB7_HUMAN (573-789): 2.11e-10: 67.8: 9.13		ANS1B_HUMAN (39-351): 1.55e-45: 175: 17.96
+	Hs
		639918 ITB7_HUMAN (573-789): 2.11e-10: 67.8: 9.13		GULP1_HUMAN (137-418): 7.16e-48: 171: 19.79
+	Hs
		855816 TITIN_HUMAN (1016-1220): 3.3e-10: 67.8: 8.17		VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97
+	Mm
		435876 ITB1_MOUSE (541-823): 1.44e-12: 75.2: 13.29		HCK_MOUSE (348-582): 2.92e-40: 155: 19.11